Chimère antigeen receptor T-cellen (CAR-T-cellen) de toekomst in immunotherapie voor auto-immuunziekten?
Doelstelling: CAR-T-celtherapie heeft een revolutie teweeggebracht in de behandeling van oncologische ziekten en recentelijk zijn mogelijke toepassingen bij auto-immuunziekten beschreven. De beoordeling heeft tot doel de beschikbare gegevens over de behandeling met CAR-T-cellen te integreren, met de nadruk op auto-immuunziekten, om de therapeutische vooruitgang en hun mogelijke toekomstige klinische toepasbaarheid bij auto-immuniteit te bepalen.
Materialen en methoden: Er is gezocht in PubMed met de trefwoorden “Chimeric Antigen Receptor” en “CART cell”. De relevante documenten werden geselecteerd en de informatie werd kritisch bekeken.
Resultaten: Bij de behandeling van auto-immuunziekten zijn in preklinische modellen drie verschillende cellulaire strategieën gebruikt, waaronder chimere antigeenreceptor T-cellen, chimere auto-antilichaamreceptor T-cellen en chimere antigeenreceptor in regulerende T-lymfocyten . Alle drie soorten therapie zijn effectief geweest. De mogelijke nadelige effecten daarin, het cytokine-afgiftesyndroom, cellulaire toxiciteit en neurotoxiciteit moeten altijd in gedachten worden gehouden.
Conclusies: Hoewel er nog geen informatie over mensen beschikbaar is, laten preklinische modellen van CAR-T-cellen bij de behandeling van auto-immuunziekten veelbelovende resultaten zien, zodat ze in de toekomst een nuttige en effectieve therapie kunnen worden bij de behandeling van deze pathologieën.
Ovalbumine Antigen -Specifieke Activatie van menselijke T-cel -receptor lijkt sterk op Oplosbare Antibody Stimulatieter onthuld door BOOST fosfotyrosine Proteomics
Activering van de T-celreceptor (TCR) leidt tot een netwerk van vroege signalering, voornamelijk georkestreerd door tyrosinefosforylering in T-cellen. De TCR wordt gewoonlijk geactiveerd met behulp van oplosbare anti-TCR-antilichamen, maar deze benadering is niet antigeenspecifiek. Als alternatief wordt aangenomen dat het activeren van de TCR met behulp van specifieke antigenen met een reeks bindingsaffiniteiten in de vorm van een peptide-major histocompatibiliteitscomplex (pMHC) meer fysiologisch is. Vanwege het ontbreken van grootschalige fosfotyrosine (pTyr) proteomische onderzoeken die anti-TCR-antilichamen en pMHC rechtstreeks vergelijken, blijft een uitgebreide definitie van deze geactiveerde toestanden echter raadselachtig.
Opheldering van het tyrosinefosfoproteoom met behulp van kwantitatieve pTyr-proteomics maakt een beter begrip mogelijk van de unieke kenmerken van deze activerende middelen en de rol van ligandbindingsaffiniteit op signalering. Hier passen we de latest opgerichte breedspectrumoptimalisatie van selectieve triggering (BOOST) toe om verstoringen in tyrosinefosforylering van menselijke TCR te onderzoeken, veroorzaakt door anti-TCR-antilichamen en pMHC. Onze gegevens laten zien dat pMHC-activering met hoge affiniteit ovalbumine (OVA) van de menselijke TCR een grotendeels vergelijkbare, zij het mogelijk sterkere, pTyr-gemedieerdesignaalregulerende as vergeleken met het anti-TCR-antilichaam. De signaleringsoutput die resulteert uit OVA pMHC-varianten correleert goed met hun zwakkere affiniteiten, waardoor affiniteit-afstembare controle van de signaalsterkte mogelijk is. Gezamenlijk bieden we een raamwerk voor het toepassen van BOOST om pTyr-gemedieerde signaalroutes van menselijke T-cellen te vergelijken die op een antigeenonafhankelijke en antigeenspecifieke manier zijn geactiveerd.

HIV-1 p24 ELISA Kit |
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Z7040001 | Biochain | 1 kit | EUR 974.4 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
HIV-1 p24 |
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E5-00024 | EnoGene | 1mg | EUR 1152 |
HIV-1 p24 |
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E62H002 | EnoGene | 100ug | EUR 458.4 |
HIV Type 1 p24 Antigen ELISA (96 Determinations) |
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0801111 | Zeptometrix | 96T | EUR 657.79 |
Description: Please contact Gentaur in order to receive the datasheet of the product. |
HIV Type 1 p24 Antigen ELISA (96 Determinations) |
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801111 | Zeptometrix | 96 Determinations | EUR 591 |
HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations) |
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801002 | Zeptometrix | 96 Determinations | EUR 574 |
HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations) |
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0801002 | Zeptometrix | 96T | EUR 603 |
HIV type 1 P24 |
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DAG1520 | Creative Diagnostics | 100 µg | EUR 972 |
HIV-1 p24 Antibody |
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7313-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains. |
HIV-1 p24 Antibody |
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7313-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains. |
Recombinant HIV-1 p24 |
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7-07603 | CHI Scientific | 100µg | Ask for price |
Recombinant HIV-1 p24 |
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7-07604 | CHI Scientific | 500µg | Ask for price |
Recombinant HIV-1 p24 |
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7-07605 | CHI Scientific | 1000µg | Ask for price |
HIV-1 Gag p24 |
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05-005 | Sceti | 50 ug | EUR 434.4 |
Description: The HIV-1 Gag p24 is available in Europe and for worldwide shipping via Gentaur. |
HIV-1 Gag p24 |
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05-006 | Sceti | 250 ug | EUR 1154.4 |
Description: The HIV-1 Gag p24 is available in Europe and for worldwide shipping via Gentaur. |
HIV-1, p24 Protein |
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abx069857-1mg | Abbexa | 1 mg | EUR 1888.8 |
HIV-1 p24 Protein |
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abx169032-1mg | Abbexa | 1 mg | EUR 661.2 |
HIV-1 p24 Antibody |
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20-abx137062 | Abbexa |
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HIV-1 p24 Antibody |
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abx021869-1mg | Abbexa | 1 mg | EUR 794.4 |
HIV-1 p24 Antibody |
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abx021870-1mg | Abbexa | 1 mg | EUR 760.8 |
HIV-1 p24 Antibody |
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abx021871-1mg | Abbexa | 1 mg | EUR 794.4 |
HIV-1 p24 Antibody |
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abx021872-1mg | Abbexa | 1 mg | EUR 794.4 |
HIV-1 p24 Antibody |
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abx021873-1mg | Abbexa | 1 mg | EUR 794.4 |
HIV-1 p24 Antibody |
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abx021882-1mg | Abbexa | 1 mg | EUR 1178.4 |
HIV-1 p24 Antibody |
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abx021883-1mg | Abbexa | 1 mg | EUR 1220.4 |
HIV-1 p24 Antibody |
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abx021886-1mg | Abbexa | 1 mg | EUR 1220.4 |
HIV-1 p24 Antibody |
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abx021887-1mg | Abbexa | 1 mg | EUR 1220.4 |
HIV-1 p24 Antibody |
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abx021888-1mg | Abbexa | 1 mg | EUR 1220.4 |
HIV-1 p24 Antibody |
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abx023027-1ml | Abbexa | 1 ml | EUR 693.6 |
HIV 1 p24 Protein |
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abx060589-1mg | Abbexa | 1 mg | EUR 1545.6 |
HIV-1 p24 Protein |
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abx061424-05mg | Abbexa | 0.5 mg | EUR 886.8 |
HIV-1 p24 Antibody |
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abx023925-1mg | Abbexa | 1 mg | EUR 828 |
HIV-1 p24 Antibody |
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abx023926-1mg | Abbexa | 1 mg | EUR 828 |
HIV-1 p24 Protein |
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20-abx261886 | Abbexa |
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p24-HIV(p24/661) Antibody |
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BNCA0661-250 | Biotium | 250uL | EUR 459.6 |
Description: Primary antibody against p24-HIV(p24/661), APC conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNCAP0661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNCAP0661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC610661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF660R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC610661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF660R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNCR0661-250 | Biotium | 250uL | EUR 459.6 |
Description: Primary antibody against p24-HIV(p24/661), RPE conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNUB0661-100 | Biotium | 100uL | EUR 250.8 |
Description: Primary antibody against p24-HIV(p24/661), Concentration: 0.2mg/mL |
p24-HIV(p24/661) Antibody |
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BNUB0661-500 | Biotium | 500uL | EUR 549.6 |
Description: Primary antibody against p24-HIV(p24/661), Concentration: 0.2mg/mL |
p24-HIV(p24/661) Antibody |
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BNC430661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF543 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC430661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF543 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC400661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC400661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC880661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC880661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC810661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC810661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNCH0661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNCH0661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNCP0661-250 | Biotium | 250uL | EUR 459.6 |
Description: Primary antibody against p24-HIV(p24/661), PerCP conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNUM0661-50 | Biotium | 50uL | EUR 474 |
Description: Primary antibody against p24-HIV(p24/661), 1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC050661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC050661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC680661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF568 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC680661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF568 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC700661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC700661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC800661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC800661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNCB0661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), Biotin conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNCB0661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), Biotin conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC940661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC940661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC550661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF555 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC550661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF555 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC470661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF647 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC470661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF647 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC040661-100 | Biotium | 100uL | EUR 238.8 |
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
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BNC040661-500 | Biotium | 500uL | EUR 652.8 |
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL |
HIV p24 Antibody |
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abx021867-1mg | Abbexa | 1 mg | EUR 1612.8 |
HIV p24 Antibody |
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abx021868-1mg | Abbexa | 1 mg | EUR 1612.8 |
Human(HIV-P24) |
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QY-E05679 | Qayee Biotechnology | 96T | EUR 433.2 |
HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations) |
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801200 | Zeptometrix | 5 X 96 Determinations | EUR 2330 |
HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations) |
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0801200 | Zeptometrix | 5 X 96T | EUR 2543.52 |
Description: Please contact Gentaur in order to receive the datasheet of the product. |
Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed |
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ELISA-1 | Alpha Diagnostics | 1 | EUR 242.4 |
HIV type 1 P24 [His] |
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DAG2375 | Creative Diagnostics | 100 µg | EUR 868.8 |
HIV type 1 P24 [His] |
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DAG2377 | Creative Diagnostics | 100 µg | EUR 868.8 |
HIV type 1 p24 [FITC] |
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DAGH004 | Creative Diagnostics | 50 Tests | EUR 1112.4 |
HIV type 1 P24 [GST] |
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DAG1516 | Creative Diagnostics | 100 µg | EUR 774 |
HIV type 1 P24 [His] |
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DAG1518 | Creative Diagnostics | 100 µg | EUR 774 |
HIV type 1 P24 [Biotin] |
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DAG1519 | Creative Diagnostics | 100 µg | EUR 972 |
HIV type 1 P24 [His] |
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DAG1799 | Creative Diagnostics | 50 ug | EUR 2017.2 |
HIV-1 p24 Recombinant Protein |
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53-341 | ProSci | 0.01 mg | EUR 789.9 |
Description: HIV-1 p24 Recombinant Protein |
Recombinant HIV-1 p24 Core |
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7-07597 | CHI Scientific | 100µg | Ask for price |
Recombinant HIV-1 p24 Core |
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7-07598 | CHI Scientific | 500µg | Ask for price |
Recombinant HIV-1 p24 Core |
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7-07599 | CHI Scientific | 1000µg | Ask for price |
Recombinant HIV-1 p24 , 24kDa |
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7-07621 | CHI Scientific | 2µg | Ask for price |
Recombinant HIV-1 p24 , 24kDa |
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7-07622 | CHI Scientific | 10µg | Ask for price |
Recombinant HIV-1 p24 , 24kDa |
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7-07623 | CHI Scientific | 100µg | Ask for price |
HIV 1 / 2 p24 Antibody |
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abx021866-1mg | Abbexa | 1 mg | EUR 1212 |
HIV-1 p24 Antibody (FITC) |
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abx021884-100ug | Abbexa | 100 ug | EUR 886.8 |
HIV 1 / 2 p24 Antibody |
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abx021890-1mg | Abbexa | 1 mg | EUR 1212 |
HIV-1 p24 Antibody (FITC) |
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abx023026-1ml | Abbexa | 1 ml | EUR 678 |
HIV-1 p24 Antibody (Biotin) |
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abx023028-1ml | Abbexa | 1 ml | EUR 794.4 |
HIV-1 p24 Antibody (HRP) |
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abx023029-1ml | Abbexa | 1 ml | EUR 886.8 |
HIV-1 p24 Core Protein |
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20-abx260141 | Abbexa |
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Polyclonal HIV-1 p24 Antibody |
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APR11116G | Leading Biology | 0.1 mg | EUR 790.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIV-1 p24 . This antibody is tested and proven to work in the following applications: |
HIV-1 p24, His tag |
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E410A26-20 | EnoGene | 20μg | EUR 520.8 |
HIV-1 p24 Antibody [8G9] |
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PM-6335-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
HIV-1 p24 Antibody [8G9] |
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PM-6335-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
HIV-1 p24 Antibody [7F4] |
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PM-6585-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
HIV-1 p24 Antibody [7F4] |
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PM-6585-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
Anti-HIV-1 p24 Antibody |
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STJ60071 | St John's Laboratory | 100 µg | EUR 508.8 |
Anti-HIV-1 p24 Antibody |
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STJ60072 | St John's Laboratory | 100 µg | EUR 508.8 |
HIV Type-1 p24 Antibody |
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V2344-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load. |
HIV Type-1 p24 Antibody |
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V2344-20UG | NSJ Bioreagents | 20 ug | EUR 219 |
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load. |
HIV Type-1 p24 Antibody |
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V2344CF488-100T | NSJ Bioreagents | 100 Tests | EUR 499 |
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load. |
HIV Type-1 p24 Antibody |
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V2344SAF-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load. |
Human HIV(1+2 antibodies plus p24 antigen (4th Generation) ELISA Kit |
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EH4101 | FN Test | 96T | EUR 571.5 |
Description: Method of detection: Qualitative ;Reacts with: Homo sapiens;Sensitivity: Qualitative |
HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations) |
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0801008 | Zeptometrix | 5 X 96T | EUR 2543.52 |
Description: Please contact Gentaur in order to receive the datasheet of the product. |
HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations) |
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801008 | Zeptometrix | 5 X 96 Determinations | EUR 2386 |
HIV-1 p24 Immune Complex Dissociation Kit |
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Z7040009 | Biochain | 1 kit | EUR 207.6 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
Anti-HIV p24 antibody |
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10-2842 | Fitzgerald | 1 mg | EUR 360 |
Description: Anti-HIV p24 Ag monoclonal antibody |
Anti-HIV p24 antibody |
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10-2843 | Fitzgerald | 1 mg | EUR 360 |
Description: Anti-HIV p24 Ag monoclonal antibody |
Anti-HIV p24 antibody |
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10-2844 | Fitzgerald | 1 mg | EUR 360 |
Description: Anti-HIV p24 Ag monoclonal antibody |
Anti-HIV p24 antibody |
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10-2845 | Fitzgerald | 1 mg | EUR 360 |
Description: Anti-HIV p24 Ag monoclonal antibody |
QuickTiter HIV Lentivirus Quantitation Kit (p24 ELISA) |
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VPK-108-H | Cell Biolabs | 96 assays | EUR 866.4 |
Description: Quantitation of the HIV-1 p24 core protein of a lentiviral vector is an efficient, well-published method for determining lentivirus physical titer. The QuickTiter Lentivirus Quantitation Kits provide a convenient method of p24 antigen quantitation. |
QuickTiter HIV Lentivirus Quantitation Kit (p24 ELISA) |
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VPK-108-H-5 | Cell Biolabs | 5 x 96 assays | EUR 3560.4 |
Description: Quantitation of the HIV-1 p24 core protein of a lentiviral vector is an efficient, well-published method for determining lentivirus physical titer. The QuickTiter Lentivirus Quantitation Kits provide a convenient method of p24 antigen quantitation. |
HIV type 1 P24 (HXBc2) [His] |
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DAG2376 | Creative Diagnostics | 100 µg | EUR 868.8 |
HIV type 1 P24 (p24HXBc2) [His] |
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DAG2378 | Creative Diagnostics | 100 µg | EUR 1095.6 |
HIV type 1 P24 (CN54) [His] |
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DAG2380 | Creative Diagnostics | 100 µg | EUR 1095.6 |
Recombinant HIV-1 p24 Core, Sf9 |
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7-07600 | CHI Scientific | 2µg | Ask for price |
Recombinant HIV-1 p24 Core, Sf9 |
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7-07601 | CHI Scientific | 10µg | Ask for price |
Recombinant HIV-1 p24 Core, Sf9 |
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7-07602 | CHI Scientific | 100µg | Ask for price |
Recombinant HIV-1 p24 His Tag |
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7-07606 | CHI Scientific | 5µg | Ask for price |
Recombinant HIV-1 p24 His Tag |
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7-07607 | CHI Scientific | 20µg | Ask for price |
Recombinant HIV-1 p24 His Tag |
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7-07608 | CHI Scientific | 1mg | Ask for price |
Recombinant HIV-1 p24, Biotin Labeled |
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7-07612 | CHI Scientific | 100µg | Ask for price |
Recombinant HIV-1 p24, Biotin Labeled |
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7-07613 | CHI Scientific | 500µg | Ask for price |
Recombinant HIV-1 p24, Biotin Labeled |
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7-07614 | CHI Scientific | 1000µg | Ask for price |
Recombinant HIV-1 gag p17, p24 |
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7-07675 | CHI Scientific | 100µg | Ask for price |
Recombinant HIV-1 gag p17, p24 |
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7-07676 | CHI Scientific | 500µg | Ask for price |
Recombinant HIV-1 gag p17, p24 |
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7-07677 | CHI Scientific | 1000µg | Ask for price |
Mouse antibody for HIV-1 p24 |
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1941 | Virostat | 100 ug | EUR 399.3 |
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA. |
Mouse antibody for HIV-1 p24 |
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1946 | Virostat | 100 ug | EUR 425.4 |
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA. |
Mouse antibody for HIV-1 p24 |
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1947 | Virostat | 100 ug | EUR 425.4 |
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA. |
Mouse antibody for HIV-1 p24 |
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1948 | Virostat | 100 ug | EUR 425.4 |
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA. |
Mouse antibody for HIV-1 p24 |
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1949 | Virostat | 100 ug | EUR 425.4 |
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA. |
HIV-1 gag p24 IIIB Protein |
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abx060586-05mg | Abbexa | 0.5 mg | EUR 1128 |
HIV-1 p24 Core, Sf9 Protein |
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20-abx260012 | Abbexa |
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HIV-1 gag p17, p24 Protein |
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20-abx260277 | Abbexa |
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HIV-1 p24, Biotin Labeled Protein |
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20-abx260358 | Abbexa |
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HIV-1 p24, 24 kDa Protein |
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20-abx263118 | Abbexa |
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Polyclonal HIV-1 p24 Antibody [7F4] |
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APR11117G | Leading Biology | 0.1 mg | EUR 790.8 |
Description: A polyclonal antibody raised in Mouse that recognizes and binds to Human HIV-1 p24 [7F4] . This antibody is tested and proven to work in the following applications: |
HIV-1 p24 Antibody [8G9] (biotin) |
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PM-6335-biotin-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
HIV-1 p24 Antibody [8G9] (biotin) |
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PM-6335-biotin-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
HIV-1 p24 Antibody [8G9] (HRP) |
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PM-6335-HRP-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
HIV-1 p24 Antibody [8G9] (HRP) |
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PM-6335-HRP-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
HIV-1 p24 Antibody [7F4] (biotin) |
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PM-6585-biotin-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
HIV-1 p24 Antibody [7F4] (biotin) |
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PM-6585-biotin-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
HIV-1 p24 Antibody [7F4] (HRP) |
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PM-6585-HRP-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
HIV-1 p24 Antibody [7F4] (HRP) |
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PM-6585-HRP-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3). |
Recombinant HIV-1 p24 Protein [His] |
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VAng-0527Lsx-inquire | Creative Biolabs | inquire | Ask for price |
Description: HIV type 1 P24 Antigen, recombinant protein from insect cell expression system. |
Recombinant HIV-1 P24 Protein (Gorillas) |
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VAng-Lsx0245-1mg | Creative Biolabs | 1 mg | EUR 3058.8 |
Description: HIV type 1 P24 (Antigen), recombinant protein from E. coli. |
Monoclonal Mouse Anti-Hiv(P24) |
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C010105-10mg | Unibiotest | 10mg | EUR 1641.6 |
Monoclonal Mouse Anti-Hiv(P24) |
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C010105-1mg | Unibiotest | 1mg | EUR 322.8 |
Recombinant HIV-I p24 gag |
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7-07618 | CHI Scientific | 100µg | Ask for price |
Recombinant HIV-I p24 gag |
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7-07619 | CHI Scientific | 500µg | Ask for price |
Recombinant HIV-I p24 gag |
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7-07620 | CHI Scientific | 1000µg | Ask for price |
anti-HIV p24 Monoclonal antibody |
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012-A-01mg | Virogen | 0,1 mg | EUR 321 |
Description: anti-HIV-1 p24 IgG1 (monoclonal) Produced against a recombinant protein. |
anti-HIV p24 Monoclonal antibody |
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012-A-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: anti-HIV-1 p24 IgG1 (monoclonal) Produced against a recombinant protein. |
HIV-I p24 gag Protein |
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20-abx260279 | Abbexa |
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Anti-HIV p24 protein antibody |
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STJ16100518 | St John's Laboratory | 100 µg | EUR 487.2 |
Anti-HIV/p24 monoclonal Antibody |
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A1020-100 | Biovision | each | EUR 444 |
Goat Anti-HIV-1 p24 Polyclonal Antibody |
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DPAB0249 | Creative Diagnostics | 1 ml | EUR 781.2 |
Goat Anti-HIV-1 p24 Polyclonal Antibody |
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DPAB0250 | Creative Diagnostics | 1 ml | EUR 826.8 |
Goat Anti-HIV-1 p24 Polyclonal Antibody |
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DPAB0251 | Creative Diagnostics | 1 ml | EUR 1146 |
HIV-1 gag Protein p24 (137-154) |
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5-01316 | CHI Scientific | 4 x 1mg | Ask for price |
HIV-1 gag Protein p24 (194-210) |
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5-01317 | CHI Scientific | 4 x 1mg | Ask for price |
Recombinant HIV-1 p24 gag, His Tag |
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7-07609 | CHI Scientific | 100µg | Ask for price |
Recombinant HIV-1 p24 gag, His Tag |
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7-07610 | CHI Scientific | 500µg | Ask for price |
Recombinant HIV-1 p24 gag, His Tag |
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7-07611 | CHI Scientific | 1000µg | Ask for price |
Recombinant HIV-1 p24, Horseradish Peroxidase Labeled |
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7-07615 | CHI Scientific | 100µg | Ask for price |
Recombinant HIV-1 p24, Horseradish Peroxidase Labeled |
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7-07616 | CHI Scientific | 500µg | Ask for price |
Recombinant HIV-1 p24, Horseradish Peroxidase Labeled |
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7-07617 | CHI Scientific | 1000µg | Ask for price |
Recombinant HIV-1 gag p17, p24, gp120 |
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7-07678 | CHI Scientific | 100µg | Ask for price |
Recombinant HIV-1 gag p17, p24, gp120 |
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7-07679 | CHI Scientific | 500µg | Ask for price |
Recombinant HIV-1 gag p17, p24, gp120 |
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7-07680 | CHI Scientific | 1000µg | Ask for price |
Anti-Capsid protein p24 (HIV-1) Purified |
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11-327-C025 | ExBio | 0.025 mg | EUR 135.6 |
Anti-Capsid protein p24 (HIV-1) Purified |
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11-327-C100 | ExBio | 0.1 mg | EUR 223.2 |
Mouse Monoclonal Anti- HIV-1 p24 IgG |
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AB-15210 | Alpha Diagnostics | 100 ug | EUR 416.4 |
HIV-1 gag p17, p24, gp120 Protein |
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20-abx260274 | Abbexa |
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HIV-1 p24, Horseradish Peroxidase Labeled Protein |
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20-abx260359 | Abbexa |
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HIV-1 gag Protein p24 (194-210) |
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H-2986.0500 | Bachem | 0.5mg | EUR 327.6 |
Description: Sum Formula: C73H126N20O23S; CAS# [141281-67-6] |
HIV-1 gag Protein p24 (194-210) |
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H-2986.1000 | Bachem | 1.0mg | EUR 559.2 |
Description: Sum Formula: C73H126N20O23S; CAS# [141281-67-6] |
HIV-1 gag Protein p24 (137-154) |
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H-3006.0500 | Bachem | 0.5mg | EUR 327.6 |
Description: Sum Formula: C92H158N26O26S; CAS# [198636-98-5] |
HIV-1 gag Protein p24 (137-154) |
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H-3006.1000 | Bachem | 1.0mg | EUR 559.2 |
Description: Sum Formula: C92H158N26O26S; CAS# [198636-98-5] |
Bilaterale anterior cerebrale slagader occlusie na CD19- en BCMA-gerichte chimere antigeen receptor van T-celtherapie voor een patiënt myeloom
Chimere antigeenreceptor T (CAR-T)-celtherapie is een veelbelovende behandeling voor recidiverend/refractair multipel myeloom (RRMM). In ons vorige rapport was CD19- en BCMA-gerichte gelijktijdige toediening van CAR-T geassocieerd met een hoog responspercentage. Hoewel cytokine launch syndrome (CRS) en neurotoxiciteit frequente complicaties zijn na behandeling met CAR-T, wordt een herseninfarct zelden gerapporteerd als een CAR-T-gerelateerde complicatie. We rapporteerden een 73-jarige vrouwelijke MM-patiënt die CD19- en BCMA-gerichte CAR-T ontving voor refractaire ziekte.
Haar ziekte reageerde op CAR-T- therapie, maar ze ontwikkelde neurologische symptomen na CRS. Craniale CT en MRI toonden meerdere herseninfarcten en bilaterale anterieure cerebrale arterie (ACA) occlusie aan. We suggereren dat een ander herseninfarct dan CAR-T-gerelateerde neurotoxiciteit de onderliggende oorzaak is van abnormale neuropsychologische symptomen, en diagnostische beeldvormingstests moeten actief worden uitgevoerd om ischemische cerebrovasculaire gebeurtenissen uit te sluiten.
Het intracellulaire domein van CD40 is een krachtige Costimulatoire Ingredient in chimère Antigen Receptoren
De co-stimulerende domeinen die zijn ingebouwd in chimere antigeenreceptoren (CAR’s) van de tweede generatie en de derde generatie, hebben een sterke invloed op de functie van CAR-T-cellen . Hier hebben we CAR’s van de tweede generatie en de derde generatie onderzocht die het signaleringsdomein van de CD40-receptor herbergen als een nieuw costimulerend component in vergelijking met vergelijkbare CAR’s die het 4-1BB-domein dragen . In CAR’s van beide generaties was CD40 krachtiger dan 4-1BB bij het triggeren van de NF-KB-signaleringsroute.
In humane T-cellen van 2 donoren was CD40 vergelijkbaar met 4-1BB bij het opreguleren van co-stimulerende en activatiemarkers, het induceren van pro-inflammatoire cytokinesecretie en het mediëren van het doden van doelwitcellen. Interessant genoeg waren er duidelijk verschillen in het responspatroon van T-cellen van de 2 donoren met betrekking tot CD40 en 4-1BB. We concluderen dat in menselijke T-cellen het CD40- signaleringsdomein een krachtig co-stimulerend component is in CAR’s van zowel de tweede generatie als de derde generatie.
Een systematische herziening van de rol van chimere Antigeen Receptor T (CAR-T) celtherapie bij de behandeling van solide tumoren
Chimere antigeenreceptor T (CAR-T) celtherapie maakt gebruik van de eigen T-lymfocyten van de patiënt die zijn ontworpen om kankercellen aan te vallen. Het is door de Meals and Drug Administration (FDA) goedgekeurd voor verschillende hematologische maligniteiten en wordt momenteel geëvalueerd bij solide kankers in vroege fase-onderzoeken. We deden een systematische evaluate bestaande uit 15 prospectieve klinische onderzoeken (n = 159) die CAR-T-cellen in solide kankers evalueerden . Vroege fase-onderzoeken toonden veelbelovende responspercentages bij ovariumepitheelkanker (100%), humaan epidermale groeifactorreceptor 2 (HER2)-positief sarcoom (67%) , epidermale groeifactorreceptor (EGFR)-positieve galwegkanker (65%), gevorderde maag-/pancreaskanker (82%), hepatocellulair carcinoom (67%),en colorectale kanker (70%) .
De mediane algehele respons voor alle maligniteiten was 62% (bereik 17%-100%) . De mediane progressievrije overleving en de totale overleving werden in de meeste onderzoeken niet bereikt. Cytokine-afgiftesyndroom werd gezien bij slechts één patiënt met cholangiocarcinoom die EGFR-specifieke CAR-T-celtherapie kreeg. Hoewel de overlevingsgegevens nog steeds niet volgroeid zijn, liet CAR-T-celtherapie bij solide maligniteiten bemoedigende responspercentages zien en werd goed verdragen.
Verschillen in lymfoompatiënten tussen chimeer antigeen receptor van T-cel therapeutische proeven en bevolking
Chimere antigeenreceptor (CAR)-T-celtherapieën lijken veelbelovende behandelingen te zijn voor non-Hodgkin- en B-cellymfoom. Verschillende CAR-T-therapieën die zijn goedgekeurd door de Amerikaanse Meals and Drug Administration, zijn echter alleen op werkzaamheid getest in relatief weinig klinische onderzoeken met een enkele arm met kleine steekproefomvang. We probeerden de verschillen tussen patiënten in deze onderzoeken en de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom te onderzoeken. Vijfhonderdtweeëntwintig patiënten uit 15 CAR-T-onderzoeken gevonden in een systematische evaluate en 417.492 patiënten uit de Surveillance, Epidemiology, and Finish Outcomes (SEER) Program-database werden vergeleken.
De deelnemers aan de CAR-T-studie leken jonger (46,7% jonger dan 70 jaar vs. 42,2%) , meer mannelijk (68,0% vs. 55,7%) en werden gedurende een kortere periode gevolgd in vergelijking met patiënten in de SEER-populatie (gemiddelde [M] 45,6 maanden, 95% betrouwbaarheidsinterval [BI] 17,7 tot 63,three maanden follow-up vs. M 57,1 maanden, 95% BI 57,Zero tot 57,three maanden overleving). Deelnemers aan de CAR-T-studie kunnen aanzienlijk verschillen van de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom . De effectiviteit van CAR-T-therapieën bij de algemene populatie van lymfoompatiënten kan verschillen van de effectiviteit die is aangetoond in onderzoeken. Nieuw gecreëerde CAR-T-patiëntenregisters zijn essentieel om de effectiviteit van de therapieën op populatieniveau huge te stellen.
Adenosine Kinase Inhibitor (hydrate) |
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C5282-1 | ApexBio | 1 mg | EUR 134.4 |
Description: IC50: 1.7 nM in cell-free assaysAdenosine Kinase Inhibitor is an inhibitor of adenosine kinase. Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations. |
DiscoveryProbe? Kinase Inhibitor Library |
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L1024-.1 | ApexBio | 100 uL/well(10 mM solution) | EUR 7520.4 |
IKK-? Kinase Inhibitor II |
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1811-1 | Biovision | each | EUR 189.6 |
VEGFR Tyrosine Kinase Inhibitor II |
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C4603-1 | ApexBio | 1 mg | EUR 141.6 |
DiscoveryProbe? Tyrosine Kinase Inhibitor Library |
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L1028-.1 | ApexBio | 100 uL/well(10 mM solution) | EUR 6476.4 |
Kinase inhibitor-1 |
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HY-43533 | MedChemExpress | 5mg | EUR 680.4 |
ET-1/ Rat ET- 1 ELISA Kit |
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ELA-E0482r | Lifescience Market | 96 Tests | EUR 1063.2 |
HPGDS inhibitor 1 |
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B1046-1 | ApexBio | 1 mg | EUR 217.2 |
Description: HPGDS inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS) with IC50 value of 0.7nM [1].Prostaglandin D2 (PGD2) is a mediator of allergy and inflammation. |
TAO Kinase inhibitor 1 |
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HY-112136 | MedChemExpress | 50mg | EUR 955.2 |
MAPKII Kinase Inhibitor (Hsp25 Kinase Inhibitor) |
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SIH-120A | Stressmarq | 1 mg | EUR 214.8 |
Description: The substance MAPKII Kinase Inhibitor is a hsp25 kinase inhibitor. It is synthetically produced and has a purity of >95%. The pure substance is white solid which is soluble in DMSO or H20. |
ET-1 Polyclonal Antibody |
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41562-100ul | SAB | 100ul | EUR 302.4 |
ET-1 Polyclonal Antibody |
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41562-50ul | SAB | 50ul | EUR 224.4 |
ET-1 Polyclonal Antibody |
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ABP52878-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of ET-1 from Human. This ET-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ET-1 |
ET-1 Polyclonal Antibody |
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ABP52878-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of ET-1 from Human. This ET-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ET-1 |
ET-1 Polyclonal Antibody |
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ABP52878-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of ET-1 from Human. This ET-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ET-1 |
ET-1 Polyclonal Antibody |
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ES3877-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against ET-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
ET-1 Polyclonal Antibody |
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ES3877-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against ET-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Anti-ET-1 antibody |
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STJ96512 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to ET-1. |
Rabbit Endothelin 1, ET-1 ELISA Kit |
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1-CSB-E06951Rb | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Rabbit Endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
rat Endothelin 1, ET-1 ELISA Kit |
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1-CSB-E06979r | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring rat Endothelin 1, ET-1 in samples from serum, plasma, cell lysates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Dog Endothelin 1, ET-1 ELISA Kit |
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1-CSB-E07002c | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Dog Endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Endothelin 1, ET-1 ELISA Kit |
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1-CSB-E07007h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Endothelin 1, ET-1 in samples from serum, cell culture supernates, urine, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Endothelin 1, ET-1 ELISA Kit |
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1-CSB-E05145m | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Endothelin 1, ET-1 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Pig endothelin 1, ET-1 ELISA Kit |
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1-CSB-E06806p | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Pig endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Cyclin-dependent kinase inhibitor 1 (CDKN1A) |
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1-CSB-EP005086HU | Cusabio |
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Description: Recombinant Human Cyclin-dependent kinase inhibitor 1(CDKN1A) expressed in E.coli |
Endothelin 1 (ET-1) Antibody |
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abx024086-100ug | Abbexa | 100 ug | EUR 1128 |
Sorafenib (Raf-1 kinase inhibitor) |
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SIH-476-10MG | Stressmarq | 10 mg | EUR 145.2 |
Description: The substance Sorafenib is a raf-1 kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is off white powder which is soluble inDMSO (200mg/ml) or ethanol (3mg/ml). |
Sorafenib (Raf-1 kinase inhibitor) |
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SIH-476-50MG | Stressmarq | 50 mg | EUR 346.8 |
Description: The substance Sorafenib is a raf-1 kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is off white powder which is soluble inDMSO (200mg/ml) or ethanol (3mg/ml). |
p16-INK4a Cyclin-Dependent Kinase Inhibitor 2A Human Recombinant Protein |
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PROTP42771-1 | BosterBio | Regular: 20ug | EUR 380.4 |
Description: CDKN2A Human Recombinant produced in E.Coli, it's a single non-glycosylated polypeptide chain containing 156 amino acids, approximately 16.5 kDa.;CDKN2A is purified by proprietary chromatographic techniques. |
187-1, N-WASP inhibitor |
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B5251-1 | ApexBio | 1 mg | EUR 478.8 |
AKT Kinase Inhibitor |
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A3150-10 | ApexBio | 10 mg | EUR 1363.2 |
Description: AKT Kinase Inhibitor |
AKT Kinase Inhibitor |
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A3150-5 | ApexBio | 5 mg | EUR 819.6 |
Description: AKT Kinase Inhibitor |
AKT Kinase Inhibitor |
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A3150-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 895.2 |
Description: AKT Kinase Inhibitor |
MAPKII Kinase Inhibitor |
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abx076811-1mg | Abbexa | 1 mg | EUR 376.8 |
Tie2 kinase inhibitor |
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A5979-100 | ApexBio | 100 mg | EUR 1452 |
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38. |
Tie2 kinase inhibitor |
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A5979-25 | ApexBio | 25 mg | EUR 477.6 |
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38. |
Tie2 kinase inhibitor |
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A5979-5 | ApexBio | 5 mg | EUR 199.2 |
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38. |
Tie2 kinase inhibitor |
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A5979-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 536.4 |
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38. |
Tie2 kinase inhibitor |
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E1KS1577 | EnoGene | 10mg | EUR 1849.2 |
AKT Kinase Inhibitor |
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HY-10249A | MedChemExpress | 10mg | EUR 1052.4 |
Tyrosine kinase inhibitor |
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HY-10421 | MedChemExpress | 25mg | EUR 459.6 |
Dasatinib (Kinase inhibitor) |
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SIH-440-25MG | Stressmarq | 25 mg | EUR 238.8 |
Description: The substance Dasatinib is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ). |
Dasatinib (Kinase inhibitor) |
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SIH-440-5MG | Stressmarq | 5 mg | EUR 160.8 |
Description: The substance Dasatinib is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ). |
K252A (Kinase inhibitor) |
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SIH-455-100UG | Stressmarq | 100 µg | EUR 157.2 |
Description: The substance K252A is a kinase inhibitor. It is nonomuraea longicatena and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in DMSO. |
K252A (Kinase inhibitor) |
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SIH-455-1MG | Stressmarq | 1 mg | EUR 358.8 |
Description: The substance K252A is a kinase inhibitor. It is nonomuraea longicatena and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in DMSO. |
K252B (Kinase inhibitor) |
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SIH-456-100UG | Stressmarq | 100 µg | EUR 218.4 |
Description: The substance K252B is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml). |
K252B (Kinase inhibitor) |
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SIH-456-1MG | Stressmarq | 1 mg | EUR 682.8 |
Description: The substance K252B is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml). |
Midostaurin (Kinase inhibitor) |
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SIH-468-1MG | Stressmarq | 1 mg | EUR 205.2 |
Description: The substance Midostaurin is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white powder which is soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml). |
Midostaurin (Kinase inhibitor) |
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SIH-468-5MG | Stressmarq | 5 mg | EUR 608.4 |
Description: The substance Midostaurin is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white powder which is soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml). |
Tie2 Kinase Inhibitor |
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B1338-25 | Biovision | each | EUR 907.2 |
Tie2 Kinase Inhibitor |
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B1338-5 | Biovision | each | EUR 314.4 |
YAP-TEAD Inhibitor 1 (Peptide 17) |
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A1149-1 | ApexBio | 1 mg | EUR 282 |
ET-1 Polyclonal Conjugated Antibody |
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C41562 | SAB | 100ul | EUR 476.4 |
Porcine ET-1 ELISA Kit |
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EPE0184 | Abclonal | 96Tests | EUR 625.2 |
Rabbit ET-1 ELISA Kit |
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ERTE0184 | Abclonal | 96Tests | EUR 625.2 |
Rat ET-1 ELISA Kit |
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ERE0184 | Abclonal | 96Tests | EUR 625.2 |
Mouse ET-1 ELISA Kit |
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EME0184 | Abclonal | 96Tests | EUR 625.2 |
Human ET-1 ELISA Kit |
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EHE0184 | Abclonal | 96Tests | EUR 625.2 |
Goat ET-1 ELISA Kit |
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EGTE0184 | Abclonal | 96Tests | EUR 625.2 |
Bovine ET-1 ELISA Kit |
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EBE0184 | Abclonal | 96Tests | EUR 625.2 |
Canine ET-1 ELISA Kit |
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ECE0184 | Abclonal | 96Tests | EUR 625.2 |
Anserini ET-1 ELISA Kit |
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EAE0184 | Abclonal | 96Tests | EUR 625.2 |
Canine ET-1 ELISA Kit |
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ELA-E0482d | Lifescience Market | 96 Tests | EUR 1113.6 |
Big ET/ Rat Big ET ELISA Kit |
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ELA-E0483r | Lifescience Market | 96 Tests | EUR 1063.2 |
ET-1(Endothelin-1) ELISA Kit |
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EU0205 | FN Test | 96T | EUR 628.92 |
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: General;Sensitivity: 0.625pg/ml |
p21/Cyclin-Dependent Kinase Inhibitor 1 |
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MO47036 | Neuromics | 100 ul | EUR 418.8 |
NFAT Inhibitor |
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A4539-1 | ApexBio | 1 mg | EUR 165.6 |
Description: Selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells. |
Lck Inhibitor |
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A3539-1 | ApexBio | 1 mg | EUR 184.8 |
Description: Lck Inhibitor is a small-molecule inhibitor of with IC50 value of 7 nM [1].The lymphocyte specific kinase which expressed in NK cells and T-cells is a member of the Src kinase family. |
EGFR Inhibitor |
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C3327-1 | ApexBio | 1 mg | EUR 184.8 |
Description: EGFR inhibitor is a cell permeable, pyrimidine compound that selectively inhibits the EGFR kinase with IC50 value of 21 nM [1]. EGFR is a transmembrane protein, and is a receptor for members of epidermal growth factor family. |
Stat5 Inhibitor |
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9484-1 | Biovision | each | EUR 144 |
Chk2 Inhibitor |
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1702-1 | Biovision | each | EUR 216 |
SCD1 Inhibitor |
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1716-1 | Biovision | each | EUR 261.6 |
ACC2 Inhibitor |
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1717-1 | Biovision | each | EUR 261.6 |
Syk Inhibitor |
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1983-1 | Biovision | each | EUR 151.2 |
Apoptosis Inhibitor |
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27734-1 | BPS Bioscience | 10 mg | EUR 150 |
Description: Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction. It does not directly inhibit caspase-3, but its effects are attributable to the inhibition of caspase-3 activation. |
Phosphatase Inhibitor Cocktail 1 (100X in DMSO) |
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K1012-1 | ApexBio | 1 ml | EUR 122.4 |
Human Cyclin-dependent kinase inhibitor 1(CDKN1A) ELISA kit |
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1-CSB-EL005086HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Cyclin-dependent kinase inhibitor 1(CDKN1A) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Cyclin-dependent kinase inhibitor 1(CDKN1A) ELISA kit |
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1-CSB-EL005086MO | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Cyclin-dependent kinase inhibitor 1(CDKN1A) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
ET-2 Antibody |
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35400-100ul | SAB | 100ul | EUR 468 |
ET-3 antibody |
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22579-100ul | SAB | 100ul | EUR 468 |
Diacylglycerol Kinase Inhibitor I |
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50R-R59022 | Fitzgerald | 50 mg | EUR 289.2 |
Description: Diacylglycerol Kinase Inhibitor I chemical reference substance |
Aurora Kinase Inhibitor III |
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B7947-.5 | ApexBio | 500 µg | EUR 141.6 |
Description: Aurora Kinase Inhibitor III |
Aurora Kinase Inhibitor III |
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B7947-5 | ApexBio | 5 mg | EUR 714 |
Description: Aurora Kinase Inhibitor III |
Adenosine Kinase Inhibitor (hydrate) |
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C5282-10 | ApexBio | 10 mg | EUR 435.6 |
Description: IC50: 1.7 nM in cell-free assaysAdenosine Kinase Inhibitor is an inhibitor of adenosine kinase. Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations. |
Adenosine Kinase Inhibitor (hydrate) |
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C5282-5 | ApexBio | 5 mg | EUR 360 |
Description: IC50: 1.7 nM in cell-free assaysAdenosine Kinase Inhibitor is an inhibitor of adenosine kinase. Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations. |
DiscoveryProbe? Kinase Inhibitor Library |
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L1024-.25 | ApexBio | 250 uL/well(10 mM solution) | EUR 13394.4 |
DiscoveryProbe? Kinase Inhibitor Library |
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L1024-5 | ApexBio | 5 mg/well | EUR 17473.2 |
RIP2 kinase inhibitor 2 |
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HY-19761 | MedChemExpress | 50mg | EUR 2539.2 |
Aurora Kinase Inhibitor 3 |
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HY-112373 | MedChemExpress | 1mg | EUR 198 |
Apigenin (Protein kinase inhibitor) |
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SIH-249-10MG | Stressmarq | 10 mg | EUR 127.2 |
Description: The substance Apigenin is a protein kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 50 mM in DMSO. |
Apigenin (Protein kinase inhibitor) |
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SIH-249-50MG | Stressmarq | 50 mg | EUR 255.6 |
Description: The substance Apigenin is a protein kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 50 mM in DMSO. |
Staurosporine (Protein kinase inhibitor) |
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SIH-253-1MG | Stressmarq | 1 mg | EUR 380.4 |
Description: The substance Staurosporine is a protein kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is pale yellow solid which is soluble to 50 mM in DMSO. |
Staurosporine (Protein kinase inhibitor) |
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SIH-253-250UG | Stressmarq | 250 µg | EUR 178.8 |
Description: The substance Staurosporine is a protein kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is pale yellow solid which is soluble to 50 mM in DMSO. |
6BIO (PDK1 kinase inhibitor) |
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SIH-422-25MG | Stressmarq | 25 mg | EUR 474 |
Description: The substance 6BIO is a pdk1 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is dark red solid which is soluble to 10 mM in DMSO and to 10 mM in ethanol. |
6BIO (PDK1 kinase inhibitor) |
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SIH-422-5MG | Stressmarq | 5 mg | EUR 178.8 |
Description: The substance 6BIO is a pdk1 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is dark red solid which is soluble to 10 mM in DMSO and to 10 mM in ethanol. |
AG1296 (PDGFR kinase inhibitor) |
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SIH-426-25MG | Stressmarq | 25 mg | EUR 608.4 |
Description: The substance AG1296 is a pdgfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white to brownish solid which is soluble in DMSO or dichloromethane. |
AG1296 (PDGFR kinase inhibitor) |
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SIH-426-5MG | Stressmarq | 5 mg | EUR 205.2 |
Description: The substance AG1296 is a pdgfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white to brownish solid which is soluble in DMSO or dichloromethane. |
CHIR99021 (GSK3? kinase inhibitor) |
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SIH-437-1MG | Stressmarq | 1 mg | EUR 151.2 |
Description: The substance CHIR99021 is a gsk3? kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to light brown solid which is soluble to 20 mM in DMSO. |
CHIR99021 (GSK3? kinase inhibitor) |
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SIH-437-5MG | Stressmarq | 5 mg | EUR 246 |
Description: The substance CHIR99021 is a gsk3? kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to light brown solid which is soluble to 20 mM in DMSO. |
Dorsomorphin (AMPK kinase inhibitor) |
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SIH-443-25MG | Stressmarq | 25 mg | EUR 514.8 |
Description: The substance Dorsomorphin is a ampk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow solid which is soluble in DMSO (4 mg/ml, warm). |
Dorsomorphin (AMPK kinase inhibitor) |
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SIH-443-5MG | Stressmarq | 5 mg | EUR 184.8 |
Description: The substance Dorsomorphin is a ampk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow solid which is soluble in DMSO (4 mg/ml, warm). |
Gefitinib (EGFR Kinase inhibitor) |
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SIH-445-250MG | Stressmarq | 250 mg | EUR 360 |
Description: The substance Gefitinib is a egfr kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is solid which is soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C). |
Gefitinib (EGFR Kinase inhibitor) |
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SIH-445-50MG | Stressmarq | 50 mg | EUR 164.4 |
Description: The substance Gefitinib is a egfr kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is solid which is soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C). |
Genistein (Tyrosine kinase inhibitor) |
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SIH-446-10MG | Stressmarq | 10 mg | EUR 117.6 |
Description: The substance Genistein is a tyrosine kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is creamy off-white solid which is soluble in DMSO (30 mg/ml), 100% ethanol (4 mg/ml) or dilute aqueous base; insoluble in water. |
Genistein (Tyrosine kinase inhibitor) |
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SIH-446-50MG | Stressmarq | 50 mg | EUR 198 |
Description: The substance Genistein is a tyrosine kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is creamy off-white solid which is soluble in DMSO (30 mg/ml), 100% ethanol (4 mg/ml) or dilute aqueous base; insoluble in water. |
GF109203X (PKC kinase inhibitor) |
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SIH-447-10MG | Stressmarq | 10 mg | EUR 306 |
Description: The substance GF109203X is a pkc kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is red solid which is soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well). |
GF109203X (PKC kinase inhibitor) |
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SIH-447-1MG | Stressmarq | 1 mg | EUR 178.8 |
Description: The substance GF109203X is a pkc kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is red solid which is soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well). |
GW2580 (cFMS kinase inhibitor) |
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SIH-449-25MG | Stressmarq | 25 mg | EUR 447.6 |
Description: The substance GW2580 is a cfms kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble in DMSO: 10 mg/ml, clear (warmed) . |
GW2580 (cFMS kinase inhibitor) |
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SIH-449-5MG | Stressmarq | 5 mg | EUR 168 |
Description: The substance GW2580 is a cfms kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble in DMSO: 10 mg/ml, clear (warmed) . |
Imatinib mesylate (Kinase inhibitor) |
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SIH-453-100MG | Stressmarq | 100 mg | EUR 279.6 |
Description: The substance Imatinib mesylate is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble H2O: soluble10 mg/ml, clear . |
Imatinib mesylate (Kinase inhibitor) |
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SIH-453-20MG | Stressmarq | 20 mg | EUR 151.2 |
Description: The substance Imatinib mesylate is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble H2O: soluble10 mg/ml, clear . |
KT5720 (PKA kinase inhibitor) |
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SIH-457-100UG | Stressmarq | 100 µg | EUR 246 |
Description: The substance KT5720 is a pka kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white powder which is soluble in methanol: clear colorless solution at 5 mg/ml. |
KT5720 (PKA kinase inhibitor) |
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SIH-457-500UG | Stressmarq | 500 µg | EUR 682.8 |
Description: The substance KT5720 is a pka kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white powder which is soluble in methanol: clear colorless solution at 5 mg/ml. |
LYS6K2 (S6 kinase inhibitor) |
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SIH-462-25MG | Stressmarq | 25 mg | EUR 582 |
Description: The substance LYS6K2 is a s6 kinase inhibitor. It is synthetically produced and has a purity of 0.97. The pure substance is yellow solid which is soluble in DMSO (up to 1 mg/ml) or DMF (up to 3 mg/ml with warming). |
LYS6K2 (S6 kinase inhibitor) |
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SIH-462-5MG | Stressmarq | 5 mg | EUR 205.2 |
Description: The substance LYS6K2 is a s6 kinase inhibitor. It is synthetically produced and has a purity of 0.97. The pure substance is yellow solid which is soluble in DMSO (up to 1 mg/ml) or DMF (up to 3 mg/ml with warming). |
PD98059 (MEK kinase inhibitor) |
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SIH-466-25MG | Stressmarq | 25 mg | EUR 514.8 |
Description: The substance PD98059 is a mek kinase inhibitor. It is synthetically produced and has a purity of ?95%. The pure substance is pale yellow solid which is soluble in DMSO (6.5 mg/ml); 25 mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6 mg/ml). |
PD98059 (MEK kinase inhibitor) |
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SIH-466-5MG | Stressmarq | 5 mg | EUR 184.8 |
Description: The substance PD98059 is a mek kinase inhibitor. It is synthetically produced and has a purity of ?95%. The pure substance is pale yellow solid which is soluble in DMSO (6.5 mg/ml); 25 mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6 mg/ml). |
PP1 (Src kinase inhibitor) |
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SIH-469-25MG | Stressmarq | 25 mg | EUR 742.8 |
Description: The substance PP1 is a src kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol. |
PP1 (Src kinase inhibitor) |
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SIH-469-5MG | Stressmarq | 5 mg | EUR 246 |
Description: The substance PP1 is a src kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol. |
PP2 (Src kinase inhibitor) |
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SIH-470-25MG | Stressmarq | 25 mg | EUR 884.4 |
Description: The substance PP2 is a src kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (25 mg/ml). |