Chimère  antigeen  receptor  T-cellen (CAR-T-cellen) de toekomst in immunotherapie voor auto-immuunziekten?

Doelstelling:  CAR-T-celtherapie heeft een revolutie teweeggebracht in de behandeling van oncologische ziekten en recentelijk zijn mogelijke toepassingen bij auto-immuunziekten beschreven. De beoordeling heeft tot doel de beschikbare gegevens over de behandeling met CAR-T-cellen te integreren, met de nadruk op auto-immuunziekten, om de therapeutische vooruitgang en hun mogelijke toekomstige klinische toepasbaarheid bij auto-immuniteit te bepalen.

Materialen en methoden:  Er is gezocht in PubMed met de trefwoorden “Chimeric Antigen Receptor” en “CART cell”. De relevante documenten werden geselecteerd en de informatie werd kritisch bekeken.

Resultaten:  Bij de behandeling van auto-immuunziekten zijn in preklinische modellen drie verschillende cellulaire strategieën gebruikt, waaronder chimere antigeenreceptor T-cellen, chimere auto-antilichaamreceptor T-cellen en chimere antigeenreceptor in regulerende T-lymfocyten . Alle drie soorten therapie zijn effectief geweest. De mogelijke nadelige effecten daarin, het cytokine-afgiftesyndroom, cellulaire toxiciteit en neurotoxiciteit moeten altijd in gedachten worden gehouden.

Conclusies:  Hoewel er nog geen informatie over mensen beschikbaar is, laten preklinische modellen van CAR-T-cellen bij de behandeling van auto-immuunziekten veelbelovende resultaten zien, zodat ze in de toekomst een nuttige en effectieve therapie kunnen worden bij de behandeling van deze pathologieën.

Ovalbumine  Antigen -Specifieke Activatie van menselijke T-cel  -receptor  lijkt sterk op Oplosbare Antibody Stimulatieter onthuld door BOOST fosfotyrosine Proteomics

Activering van de T-celreceptor (TCR) leidt tot een netwerk van vroege signalering, voornamelijk georkestreerd door tyrosinefosforylering in T-cellen. De TCR wordt gewoonlijk geactiveerd met behulp van oplosbare anti-TCR-antilichamen, maar deze benadering is niet antigeenspecifiek. Als alternatief wordt aangenomen dat het activeren van de TCR met behulp van specifieke antigenen met een reeks bindingsaffiniteiten in de vorm van een peptide-major histocompatibiliteitscomplex (pMHC) meer fysiologisch is. Vanwege het ontbreken van grootschalige fosfotyrosine (pTyr) proteomische onderzoeken die anti-TCR-antilichamen en pMHC rechtstreeks vergelijken, blijft een uitgebreide definitie van deze geactiveerde toestanden echter raadselachtig.

Opheldering van het tyrosinefosfoproteoom met behulp van kwantitatieve pTyr-proteomics maakt een beter begrip mogelijk van de unieke kenmerken van deze activerende middelen en de rol van ligandbindingsaffiniteit op signalering. Hier passen we de latest opgerichte breedspectrumoptimalisatie van selectieve triggering (BOOST) toe om verstoringen in tyrosinefosforylering van menselijke TCR te onderzoeken, veroorzaakt door anti-TCR-antilichamen en pMHC. Onze gegevens laten zien dat pMHC-activering met hoge affiniteit ovalbumine (OVA) van de menselijke TCR een grotendeels vergelijkbare, zij het mogelijk sterkere, pTyr-gemedieerdesignaalregulerende as vergeleken met het anti-TCR-antilichaam. De signaleringsoutput die resulteert uit OVA pMHC-varianten correleert goed met hun zwakkere affiniteiten, waardoor affiniteit-afstembare controle van de signaalsterkte mogelijk is. Gezamenlijk bieden we een raamwerk voor het toepassen van BOOST om pTyr-gemedieerde signaalroutes van menselijke T-cellen te vergelijken die op een antigeenonafhankelijke en antigeenspecifieke manier zijn geactiveerd.

HIV-P24 antigen array kit
VArk-Lsx001	Creative Biolabs	unit	Ask for price
Description: Fourth-generation HIV immunoassays detect viral p24 protein in the blood.

HIV-1 p17-p24 recombinant antigen.
00172-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-1 p17-p24 recombinant antigen.

HIV-1 GAG P24 Recombinant Antigen
00111-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen
00111-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV 1 p24 core recombinant antigen
00177-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen
00177-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen.
00177-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV 1 p24 core recombinant antigen.

HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations)
0801200	Zeptometrix	5 X 96T	EUR 2563

HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations)
801200	Zeptometrix	5 X 96 Determinations	EUR 2330

HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations)
801008	Zeptometrix	5 X 96 Determinations	EUR 2386

HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations)
0801008	Zeptometrix	5 X 96T	EUR 2505

Human HIV(1+2 antibodies plus p24 antigen (4th Generation) ELISA Kit
EH4101	FN Test	96T	EUR 571.5
Description: Method of detection: Qualitative ;Reacts with: Homo sapiens;Sensitivity: Qualitative

HIV-1 p24 ELISA Kit
Z7040001	Biochain	1 kit	EUR 752

HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa
00111-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 p17/24/gp120 antigen
00169-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

HIV-1 p17/24/gp120 antigen
00169-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

HIV-1 intergase antigen
00199-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 intergase antigen. The protein contains the HIV-1 immunodominant regions from pol protein (integrase).

HIV-1 intergase antigen
00199-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 intergase antigen. The protein contains the HIV-1 immunodominant regions from pol protein (integrase).

HIV-1 p24 Antibody
20-abx137062	Abbexa	EUR 427.20 EUR 627.60	0.5 mg 1 mg

HIV-1 p24 Antibody
7313-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains.

HIV-1 p24 Antibody
7313-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains.

HIV-1 p24 Antibody
abx021869-1mg	Abbexa	1 mg	EUR 794.4

HIV-1 p24 Antibody
abx021870-1mg	Abbexa	1 mg	EUR 760.8

HIV-1 p24 Antibody
abx021871-1mg	Abbexa	1 mg	EUR 794.4

HIV-1 p24 Antibody
abx021872-1mg	Abbexa	1 mg	EUR 794.4

HIV-1 p24 Antibody
abx021873-1mg	Abbexa	1 mg	EUR 794.4

HIV-1 p24 Antibody
abx021882-1mg	Abbexa	1 mg	EUR 1178.4

HIV-1 p24 Antibody
abx021883-1mg	Abbexa	1 mg	EUR 1220.4

HIV-1 p24 Antibody
abx021886-1mg	Abbexa	1 mg	EUR 1220.4

HIV-1 p24 Antibody
abx021887-1mg	Abbexa	1 mg	EUR 1220.4

HIV-1 p24 Antibody
abx021888-1mg	Abbexa	1 mg	EUR 1220.4

HIV-1 p24 Antibody
abx023027-1ml	Abbexa	1 ml	EUR 693.6

HIV-1 p24 Antibody
abx023925-1mg	Abbexa	1 mg	EUR 828

HIV-1 p24 Antibody
abx023926-1mg	Abbexa	1 mg	EUR 828

HIV-1 p24
E5-00024	EnoGene	1mg	EUR 1152

HIV-1 p24
E62H002	EnoGene	100ug	EUR 458.4

HIV-1 tat recombinant antigen
00110-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 tat recombinant antigen
00110-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 nef recombinant antigen
00112-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 nef recombinant antigen
00112-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 gag recombinant antigen
8934	Virostat	100 ug	EUR 542.86
Description: This is HIV-1 gag recombinant antigen for ELISA,WB.

HIV-1 nef recombinant antigen
8941	Virostat	100 ug	EUR 477.6
Description: This is HIV-1 nef recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen,
00170-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 gp41 recombinant antigen.

HIV-1 gp41 recombinant antigen,
00170-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 gp41 recombinant antigen.

HIV-1 gp41 recombinant antigen
8908	Virostat	100 ug	EUR 673.36
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen
8933	Virostat	100 ug	EUR 477.6
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen
9000	Virostat	100 ug	EUR 484.13
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen
9001	Virostat	100 ug	EUR 484.13
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen.
00170-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-1 gp41 recombinant antigen.

HIV p24 Antibody
abx021867-1mg	Abbexa	1 mg	EUR 1612.8

HIV p24 Antibody
abx021868-1mg	Abbexa	1 mg	EUR 1612.8

HIV-1 p17/24/gp120-gp41 recombinant antigen,
00168-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 p17/24/gp120-gp41 recombinant antigen.

HIV-1 p17/24/gp120-gp41 recombinant antigen,
00168-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 p17/24/gp120-gp41 recombinant antigen.

HIV-1 p17/24/gp120-gp41 recombinant antigen.
00168-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-1 p17/24/gp120-gp41 recombinant antigen.

HIV 1 envelope recombinant antigen
00176-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV 1 envelope recombinant antigen. HIV-1 evnelope protein spanning the C-Terminus of gp 120 and most of gp 41.

HIV 1 envelope recombinant antigen
00176-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV 1 envelope recombinant antigen. HIV-1 evnelope protein spanning the C-Terminus of gp 120 and most of gp 41.

ToX Antigen (P24,GRA1)
E61Y00305	EnoGene	1mg	EUR 840

HIV-1 p24 Antibody (HRP)
abx023029-1ml	Abbexa	1 ml	EUR 886.8

HIV-1 p24 Antibody [8G9]
PM-6335-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9]
PM-6335-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4]
PM-6585-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4]
PM-6585-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 env gp41 recombinant antigen
00113-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 env gp41 recombinant antigen
00113-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 p24 Antibody (FITC)
abx021884-100ug	Abbexa	100 ug	EUR 886.8

HIV-1 p24 Antibody (FITC)
abx023026-1ml	Abbexa	1 ml	EUR 678

HIV 1 / 2 p24 Antibody
abx021866-1mg	Abbexa	1 mg	EUR 1212

HIV 1 / 2 p24 Antibody
abx021890-1mg	Abbexa	1 mg	EUR 1212

HIV-1 gp41 Long recombinant antigen,
00171-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 gp41 Long recombinant antigen.

HIV-1 gp41 Long recombinant antigen,
00171-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 gp41 Long recombinant antigen.

HIV-1 gp41 Long recombinant antigen.
00171-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-1 gp41 Long recombinant antigen.

HIV-1 p24 Antibody (Biotin)
abx023028-1ml	Abbexa	1 ml	EUR 794.4

Polyclonal HIV-1 p24 Antibody
APR11116G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIV-1 p24 . This antibody is tested and proven to work in the following applications:

HIV-1 p24 Protein
20-abx261886	Abbexa	EUR 5388.00 EUR 393.60 EUR 276.00	1 mg 20 ug 5 ug

HIV-1 p24 Protein
abx169032-1mg	Abbexa	1 mg	EUR 661.2

HIV-1 p24 Protein
abx061424-05mg	Abbexa	0.5 mg	EUR 886.8

HIV-1, p24 Protein
abx069857-1mg	Abbexa	1 mg	EUR 1888.8

HIV-1 Gag p24
05-005	Sceti	50 ug	EUR 434.4
Description: The HIV-1 Gag p24 is available in Europe and for worldwide shipping via Gentaur.

HIV-1 Gag p24
05-006	Sceti	250 ug	EUR 1154.4
Description: The HIV-1 Gag p24 is available in Europe and for worldwide shipping via Gentaur.

Recombinant HIV-1 p24
7-07603	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 p24
7-07604	CHI Scientific	500µg	Ask for price

Recombinant HIV-1 p24
7-07605	CHI Scientific	1000µg	Ask for price

HIV 1 p24 Protein
abx060589-1mg	Abbexa	1 mg	EUR 1545.6

HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.
00169-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

HIV 1, 2 envelope recombinant antigen
00175-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV 1, 2 envelope recombinant antigen. HIV-1 envelope conjugated to HIV-2 envelope peptide.

HIV 1, 2 envelope recombinant antigen
00175-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV 1, 2 envelope recombinant antigen. HIV-1 envelope conjugated to HIV-2 envelope peptide.

HIV-1 reverse transcriptase recombinant antigen
00198-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 reverse transcriptase recombinant antigen.

HIV-1 reverse transcriptase recombinant antigen
00198-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 reverse transcriptase recombinant antigen.

HIV-1 reverse transcriptase recombinant antigen.
00198-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-1 reverse transcriptase recombinant antigen.

Feline Immunodeficiency Virus p24 Antigen (FIV p24) Antibody
abx411336-02mg	Abbexa	0.2 mg	EUR 710.4

Feline Immunodeficiency Virus p24 Antigen (FIV p24) Antibody
abx412988-2ml	Abbexa	2 ml	EUR 727.2

HIV Type-1 p24 Antibody
V2344-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody
V2344-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody
V2344CF488-100T	NSJ Bioreagents	100 Tests	EUR 349.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody
V2344SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV-2 gp32 recombinant antigen
00173-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-2 gp32 recombinant antigen. .

HIV-2 gp32 recombinant antigen
00173-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-2 gp32 recombinant antigen. .

HIV-2 gp36 recombinant antigen
8911	Virostat	100 ug	EUR 673.36
Description: This is HIV-2 gp36 recombinant antigen for ELISA,WB.

HIV-2 gp36 recombinant antigen
8949	Virostat	100 ug	EUR 529.8
Description: This is HIV-2 gp36 recombinant antigen for ELISA,WB.

HIV-2 gp36 recombinant antigen
9003	Virostat	100 ug	EUR 484.13
Description: This is HIV-2 gp36 recombinant antigen for ELISA,WB.

HIV-2 gp32 recombinant antigen. .
00173-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-2 gp32 recombinant antigen. .

HIV type 1 P24
DAG1520	Creative Diagnostics	100 µg	EUR 972

HIV-1 p24 Antibody [8G9] (HRP)
PM-6335-HRP-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9] (HRP)
PM-6335-HRP-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (HRP)
PM-6585-HRP-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (HRP)
PM-6585-HRP-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9] (biotin)
PM-6335-biotin-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9] (biotin)
PM-6335-biotin-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (biotin)
PM-6585-biotin-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (biotin)
PM-6585-biotin-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV type O envelope antigen
00178-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV type O envelope antigen. Synthetic HIV type-O peptide, containing the HIV type-O envelope-derived sequence.

HIV type O envelope antigen
00178-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV type O envelope antigen. Synthetic HIV type-O peptide, containing the HIV type-O envelope-derived sequence.

HIV 2 gp36 envelope antigen
00180-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV 2 gp36 envelope antigen. Synthetic HIV-2 Peptide containing the HIV-2 specific sequence of gp36.

HIV 2 gp36 envelope antigen
00180-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV 2 gp36 envelope antigen. Synthetic HIV-2 Peptide containing the HIV-2 specific sequence of gp36.

Polyclonal HIV-1 p24 Antibody [7F4]
APR11117G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Mouse that recognizes and binds to Human HIV-1 p24 [7F4] . This antibody is tested and proven to work in the following applications:

HIV 1, 2 envelope recombinant antigen. HIV-1 envelope conjugated to HIV-2 envelope peptide.
00175-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV 1, 2 envelope recombinant antigen. HIV-1 envelope conjugated to HIV-2 envelope peptide.

HIV-2 GP 36 Recombinant Antigen
00114-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HIV-2 GP 36 Recombinant Antigen
00114-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HIV-1 p24, His tag
E410A26-20	EnoGene	20μg	EUR 520.8

HIV-1 p24 Core Protein
20-abx260141	Abbexa	EUR 1062.00 EUR 410.40 EUR 1646.40	0.5 mg 100 ug 1 mg

Mouse antibody for HIV-1 p24
1941	Virostat	100 ug	EUR 399.3
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA.

Mouse antibody for HIV-1 p24
1946	Virostat	100 ug	EUR 425.4
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA.

Mouse antibody for HIV-1 p24
1947	Virostat	100 ug	EUR 425.4
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA.

Mouse antibody for HIV-1 p24
1948	Virostat	100 ug	EUR 425.4
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA.

Mouse antibody for HIV-1 p24
1949	Virostat	100 ug	EUR 425.4
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA.

Recombinant HIV-1 p24 Core
7-07597	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 p24 Core
7-07598	CHI Scientific	500µg	Ask for price

Recombinant HIV-1 p24 Core
7-07599	CHI Scientific	1000µg	Ask for price

QuickTiter HIV Lentivirus Quantitation Kit (p24 ELISA)
VPK-108-H	Cell Biolabs	96 assays	EUR 866.4
Description: Quantitation of the HIV-1 p24 core protein of a lentiviral vector is an efficient, well-published method for determining lentivirus physical titer. The QuickTiter Lentivirus Quantitation Kits provide a convenient method of p24 antigen quantitation.

QuickTiter HIV Lentivirus Quantitation Kit (p24 ELISA)
VPK-108-H-5	Cell Biolabs	5 x 96 assays	EUR 3560.4
Description: Quantitation of the HIV-1 p24 core protein of a lentiviral vector is an efficient, well-published method for determining lentivirus physical titer. The QuickTiter Lentivirus Quantitation Kits provide a convenient method of p24 antigen quantitation.

Recombinant HIV-1 p24 , 24kDa
7-07621	CHI Scientific	2µg	Ask for price

Recombinant HIV-1 p24 , 24kDa
7-07622	CHI Scientific	10µg	Ask for price

Recombinant HIV-1 p24 , 24kDa
7-07623	CHI Scientific	100µg	Ask for price

HIV-1 p24 Recombinant Protein
53-341	ProSci	0.01 mg	EUR 789.9
Description: HIV-1 p24 Recombinant Protein

HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa
00112-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa
00113-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV -2 env gp36 recombinant antigen
00179-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV -2 env gp36 recombinant antigen. a.a 390 to a.a 702.

HIV -2 env gp36 recombinant antigen
00179-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV -2 env gp36 recombinant antigen. a.a 390 to a.a 702.

HIV type 1 P24 [GST]
DAG1516	Creative Diagnostics	100 µg	EUR 774

HIV type 1 P24 [His]
DAG1518	Creative Diagnostics	100 µg	EUR 774

HIV type 1 P24 [His]
DAG1799	Creative Diagnostics	50 ug	EUR 2017.2

HIV type 1 P24 [His]
DAG2375	Creative Diagnostics	100 µg	EUR 868.8

HIV type 1 P24 [His]
DAG2377	Creative Diagnostics	100 µg	EUR 868.8

HIV-1 tat recombinant antigen full length 15 kDa
00110-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 p24 Immune Complex Dissociation Kit
Z7040009	Biochain	1 kit	EUR 122

HIV type 1 p24 [FITC]
DAGH004	Creative Diagnostics	50 Tests	EUR 1112.4

HTLV-I p24 core recombinant antigen
00204-V-01mg	Virogen	0,1 mg	EUR 321
Description: HLTV-I p24 core recombinant antigen.

HTLV-I p24 core recombinant antigen
00204-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HLTV-I p24 core recombinant antigen.

HLTV-I p24 core recombinant antigen.
00204-V-100ugvial	Virogen	100 ug/vial	EUR 150
Description: HLTV-I p24 core recombinant antigen.

HIV type 1 P24 [Biotin]
DAG1519	Creative Diagnostics	100 µg	EUR 972

Feline Immunodeficiency Virus p24 gag Antigen (FIV p24 gag) Antibody
abx413943-025mg	Abbexa	0.25 mg	EUR 811.2

HIV-1 gag p17, p24 Protein
20-abx260277	Abbexa	EUR 1062.00 EUR 410.40 EUR 1930.80	0.5 mg 100 ug 1 mg

HIV-1 p24, 24 kDa Protein
20-abx263118	Abbexa	EUR 1562.40 EUR 393.60 EUR 276.00	100 ug 10 ug 2 µg

Recombinant HIV-1 gag p17, p24
7-07675	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 gag p17, p24
7-07676	CHI Scientific	500µg	Ask for price

Recombinant HIV-1 gag p17, p24
7-07677	CHI Scientific	1000µg	Ask for price

Felis p27 core antigen ELISA Kit
ELA-E1491FELA-E	Lifescience Market	96 Tests	EUR 1113.6

HIV-1 p24 Core, Sf9 Protein
20-abx260012	Abbexa	EUR 2815.20 EUR 493.20 EUR 276.00	100 ug 10 ug 2 µg

Mouse Monoclonal Anti- HIV-1 p24 IgG
AB-15210	Alpha Diagnostics	100 ug	EUR 416.4

Toxoplasma gondii P24 (GRA1) recombinant antigen
00207-V-01mg	Virogen	0,1 mg	EUR 321
Description: Toxoplasma gondii P24 (GRA1) recombinant antigen

Toxoplasma gondii P24 (GRA1) recombinant antigen
00207-V-1000ug	Virogen	1000 ug	EUR 1539
Description: Toxoplasma gondii P24 (GRA1) recombinant antigen

Toxoplasma gondii P24 (GRA1) recombinant antigen
00207-V-100ugvial	Virogen	100ug/vial	EUR 150
Description: Toxoplasma gondii P24 (GRA1) recombinant antigen

HIV-1 gp120 and gp41 Chimeric Antigen (16 kDa, Capture)
DAGF-220	Creative Diagnostics	1mg	EUR 817.2

HIV-1 gp120 and gp41 Chimeric Antigen (8 kDa, Capture)
DAGF-222	Creative Diagnostics	1mg	EUR 817.2

HIV-1 gp120 and gp41 Chimeric Antigen (45 kDa, Capture)
DAGF-224	Creative Diagnostics	1mg	EUR 817.2

Recombinant HIV-1 p24 His Tag
7-07606	CHI Scientific	5µg	Ask for price

Recombinant HIV-1 p24 His Tag
7-07607	CHI Scientific	20µg	Ask for price

Recombinant HIV-1 p24 His Tag
7-07608	CHI Scientific	1mg	Ask for price

Recombinant HIV-1 p24 Core, Sf9
7-07602	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 p24 Core, Sf9
7-07600	CHI Scientific	2µg	Ask for price

Recombinant HIV-1 p24 Core, Sf9
7-07601	CHI Scientific	10µg	Ask for price

HIV-1 gp120 and gp41 Chimeric Antigen (43 kDa, Detection)
DAGF-223	Creative Diagnostics	1mg	EUR 817.2

HIV-1 p24, Biotin Labeled Protein
20-abx260358	Abbexa	EUR 1496.40 EUR 560.40 EUR 2364.00	0.5 mg 100 ug 1 mg

p24-HIV(p24/661) Antibody
BNCA0661-250	Biotium	250uL	EUR 459.6
Description: Primary antibody against p24-HIV(p24/661), APC conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC800661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC800661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC810661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC810661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC940661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC940661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC700661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC700661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC880661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC880661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC050661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC050661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC040661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC040661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC400661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC400661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL

Bilaterale anterior cerebrale slagader occlusie na CD19- en BCMA-gerichte chimere  antigeen  receptor  van T-celtherapie voor een patiënt myeloom

Chimere antigeenreceptor T (CAR-T)-celtherapie is een veelbelovende behandeling voor recidiverend/refractair multipel myeloom (RRMM). In ons vorige rapport was CD19- en BCMA-gerichte gelijktijdige toediening van CAR-T geassocieerd met een hoog responspercentage. Hoewel cytokine launch syndrome (CRS) en neurotoxiciteit frequente complicaties zijn na behandeling met CAR-T, wordt een herseninfarct zelden gerapporteerd als een CAR-T-gerelateerde complicatie. We rapporteerden een 73-jarige vrouwelijke MM-patiënt die CD19- en BCMA-gerichte CAR-T ontving voor refractaire ziekte.

Haar ziekte reageerde op CAR-T- therapie, maar ze ontwikkelde neurologische symptomen na CRS. Craniale CT en MRI toonden meerdere herseninfarcten en bilaterale anterieure cerebrale arterie (ACA) occlusie aan. We suggereren dat een ander herseninfarct dan CAR-T-gerelateerde neurotoxiciteit de onderliggende oorzaak is van abnormale neuropsychologische symptomen, en diagnostische beeldvormingstests moeten actief worden uitgevoerd om ischemische cerebrovasculaire gebeurtenissen uit te sluiten.

Het intracellulaire domein van CD40 is een krachtige Costimulatoire Ingredient in chimère  Antigen  Receptoren

De co-stimulerende domeinen die zijn ingebouwd in chimere antigeenreceptoren (CAR’s) van de tweede generatie en de derde generatie, hebben een sterke invloed op de functie van CAR-T-cellen . Hier hebben we CAR’s van de tweede generatie en de derde generatie onderzocht die het signaleringsdomein van de CD40-receptor herbergen als een nieuw costimulerend component in vergelijking met vergelijkbare CAR’s die het 4-1BB-domein dragen . In CAR’s van beide generaties was CD40 krachtiger dan 4-1BB bij het triggeren van de NF-KB-signaleringsroute.

In humane T-cellen van 2 donoren was CD40 vergelijkbaar met 4-1BB bij het opreguleren van co-stimulerende en activatiemarkers, het induceren van pro-inflammatoire cytokinesecretie en het mediëren van het doden van doelwitcellen. Interessant genoeg waren er duidelijk verschillen in het responspatroon van T-cellen van de 2 donoren met betrekking tot CD40 en 4-1BB. We concluderen dat in menselijke T-cellen het CD40- signaleringsdomein een krachtig co-stimulerend component is in CAR’s van zowel de tweede generatie als de derde generatie.

Een systematische herziening van de rol van chimere  Antigeen  Receptor  T (CAR-T) celtherapie bij de behandeling van solide tumoren

Chimere antigeenreceptor T (CAR-T) celtherapie maakt gebruik van de eigen T-lymfocyten van de patiënt die zijn ontworpen om kankercellen aan te vallen. Het is door de Meals and Drug Administration (FDA) goedgekeurd voor verschillende hematologische maligniteiten en wordt momenteel geëvalueerd bij solide kankers in vroege fase-onderzoeken. We deden een systematische evaluate bestaande uit 15 prospectieve klinische onderzoeken (n = 159) die CAR-T-cellen in solide kankers evalueerden . Vroege fase-onderzoeken toonden veelbelovende responspercentages bij ovariumepitheelkanker (100%), humaan epidermale groeifactorreceptor 2  (HER2)-positief sarcoom (67%) , epidermale groeifactorreceptor (EGFR)-positieve galwegkanker (65%), gevorderde maag-/pancreaskanker (82%), hepatocellulair carcinoom (67%),en colorectale kanker (70%) .

De mediane algehele respons voor alle maligniteiten was 62% (bereik 17%-100%) . De mediane progressievrije overleving en de totale overleving werden in de meeste onderzoeken niet bereikt. Cytokine-afgiftesyndroom werd gezien bij slechts één patiënt met cholangiocarcinoom die EGFR-specifieke CAR-T-celtherapie kreeg. Hoewel de overlevingsgegevens nog steeds niet volgroeid zijn, liet CAR-T-celtherapie bij solide maligniteiten bemoedigende responspercentages zien en werd goed verdragen.

Verschillen in lymfoompatiënten tussen chimeer  antigeen  receptor  van T-cel therapeutische proeven en bevolking

Chimere antigeenreceptor (CAR)-T-celtherapieën lijken veelbelovende behandelingen te zijn voor non-Hodgkin- en B-cellymfoom. Verschillende CAR-T-therapieën die zijn goedgekeurd door de Amerikaanse Meals and Drug Administration, zijn echter alleen op werkzaamheid getest in relatief weinig klinische onderzoeken met een enkele arm met kleine steekproefomvang. We probeerden de verschillen tussen patiënten in deze onderzoeken en de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom te onderzoeken. Vijfhonderdtweeëntwintig patiënten uit 15 CAR-T-onderzoeken gevonden in een systematische evaluate en 417.492 patiënten uit de Surveillance, Epidemiology, and Finish Outcomes (SEER) Program-database werden vergeleken.

De deelnemers aan de CAR-T-studie leken jonger (46,7% jonger dan 70 jaar vs. 42,2%) , meer mannelijk (68,0% vs. 55,7%) en werden gedurende een kortere periode gevolgd in vergelijking met patiënten in de SEER-populatie (gemiddelde [M] 45,6 maanden, 95% betrouwbaarheidsinterval [BI] 17,7 tot 63,three maanden follow-up vs. M 57,1 maanden, 95% BI 57,Zero tot 57,three maanden overleving). Deelnemers aan de CAR-T-studie kunnen aanzienlijk verschillen van de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom . De effectiviteit van CAR-T-therapieën bij de algemene populatie van lymfoompatiënten kan verschillen van de effectiviteit die is aangetoond in onderzoeken. Nieuw gecreëerde CAR-T-patiëntenregisters zijn essentieel om de effectiviteit van de therapieën op populatieniveau huge te stellen.

 

Tie2 Kinase Inhibitor
B1338-5	Biovision	each	EUR 314.4

Tie2 kinase inhibitor
A5979-100	ApexBio	100 mg	EUR 1452
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor
A5979-25	ApexBio	25 mg	EUR 477.6
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor
A5979-5	ApexBio	5 mg	EUR 199.2
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor
A5979-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 536.4
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor
E1KS1577	EnoGene	10mg	EUR 1849.2

K252A (Kinase inhibitor)
SIH-455-100UG	Stressmarq	100 µg	EUR 157.2
Description: The substance K252A is a kinase inhibitor. It is nonomuraea longicatena and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in DMSO.

K252A (Kinase inhibitor)
SIH-455-1MG	Stressmarq	1 mg	EUR 358.8
Description: The substance K252A is a kinase inhibitor. It is nonomuraea longicatena and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in DMSO.

K252B (Kinase inhibitor)
SIH-456-100UG	Stressmarq	100 µg	EUR 218.4
Description: The substance K252B is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml).

K252B (Kinase inhibitor)
SIH-456-1MG	Stressmarq	1 mg	EUR 682.8
Description: The substance K252B is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml).

MAPKII Kinase Inhibitor
abx076811-1mg	Abbexa	1 mg	EUR 376.8

Sorafenib (Raf-1 kinase inhibitor)
SIH-476-10MG	Stressmarq	10 mg	EUR 145.2
Description: The substance Sorafenib is a raf-1 kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is off white powder which is soluble inDMSO (200mg/ml) or ethanol (3mg/ml).

Sorafenib (Raf-1 kinase inhibitor)
SIH-476-50MG	Stressmarq	50 mg	EUR 346.8
Description: The substance Sorafenib is a raf-1 kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is off white powder which is soluble inDMSO (200mg/ml) or ethanol (3mg/ml).

Tyrosine kinase inhibitor
HY-10421	MedChemExpress	25mg	EUR 459.6

Dasatinib (Kinase inhibitor)
SIH-440-25MG	Stressmarq	25 mg	EUR 238.8
Description: The substance Dasatinib is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ).

Dasatinib (Kinase inhibitor)
SIH-440-5MG	Stressmarq	5 mg	EUR 160.8
Description: The substance Dasatinib is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ).

IKK-? Kinase Inhibitor II
1811-1	Biovision	each	EUR 189.6

IKK-? Kinase Inhibitor II
1811-5	Biovision	each	EUR 574.8

RIP2 kinase inhibitor 2
HY-19761	MedChemExpress	50mg	EUR 2539.2

PP1 (Src kinase inhibitor)
SIH-469-25MG	Stressmarq	25 mg	EUR 742.8
Description: The substance PP1 is a src kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol.

PP1 (Src kinase inhibitor)
SIH-469-5MG	Stressmarq	5 mg	EUR 246
Description: The substance PP1 is a src kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol.

PP2 (Src kinase inhibitor)
SIH-470-25MG	Stressmarq	25 mg	EUR 884.4
Description: The substance PP2 is a src kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (25 mg/ml).

PP2 (Src kinase inhibitor)
SIH-470-5MG	Stressmarq	5 mg	EUR 279.6
Description: The substance PP2 is a src kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (25 mg/ml).

C16 (PKR kinase inhibitor)
SIH-498-25MG	Stressmarq	25 mg	EUR 420
Description: The substance C16 is a pkr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is solid which is soluble in DMSO 12 mg/ml .

C16 (PKR kinase inhibitor)
SIH-498-5MG	Stressmarq	5 mg	EUR 164.4
Description: The substance C16 is a pkr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is solid which is soluble in DMSO 12 mg/ml .

Midostaurin (Kinase inhibitor)
SIH-468-1MG	Stressmarq	1 mg	EUR 205.2
Description: The substance Midostaurin is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white powder which is soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml).

Midostaurin (Kinase inhibitor)
SIH-468-5MG	Stressmarq	5 mg	EUR 608.4
Description: The substance Midostaurin is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white powder which is soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml).

Aurora Kinase Inhibitor 3
HY-112373	MedChemExpress	1mg	EUR 198

6BIO (PDK1 kinase inhibitor)
SIH-422-25MG	Stressmarq	25 mg	EUR 474
Description: The substance 6BIO is a pdk1 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is dark red solid which is soluble to 10 mM in DMSO and to 10 mM in ethanol.

6BIO (PDK1 kinase inhibitor)
SIH-422-5MG	Stressmarq	5 mg	EUR 178.8
Description: The substance 6BIO is a pdk1 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is dark red solid which is soluble to 10 mM in DMSO and to 10 mM in ethanol.

LYS6K2 (S6 kinase inhibitor)
SIH-462-25MG	Stressmarq	25 mg	EUR 582
Description: The substance LYS6K2 is a s6 kinase inhibitor. It is synthetically produced and has a purity of 0.97. The pure substance is yellow solid which is soluble in DMSO (up to 1 mg/ml) or DMF (up to 3 mg/ml with warming).

LYS6K2 (S6 kinase inhibitor)
SIH-462-5MG	Stressmarq	5 mg	EUR 205.2
Description: The substance LYS6K2 is a s6 kinase inhibitor. It is synthetically produced and has a purity of 0.97. The pure substance is yellow solid which is soluble in DMSO (up to 1 mg/ml) or DMF (up to 3 mg/ml with warming).

Aurora Kinase Inhibitor III
B7947-.5	ApexBio	500 µg	EUR 141.6
Description: Aurora Kinase Inhibitor III

Aurora Kinase Inhibitor III
B7947-1	ApexBio	1 mg	EUR 214.8
Description: Aurora Kinase Inhibitor III

Aurora Kinase Inhibitor III
B7947-5	ApexBio	5 mg	EUR 714
Description: Aurora Kinase Inhibitor III

KT5720 (PKA kinase inhibitor)
SIH-457-100UG	Stressmarq	100 µg	EUR 246
Description: The substance KT5720 is a pka kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white powder which is soluble in methanol: clear colorless solution at 5 mg/ml.

KT5720 (PKA kinase inhibitor)
SIH-457-500UG	Stressmarq	500 µg	EUR 682.8
Description: The substance KT5720 is a pka kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white powder which is soluble in methanol: clear colorless solution at 5 mg/ml.

ml167 (Clk4 kinase inhibitor)
SIH-505-25MG	Stressmarq	25 mg	EUR 608.4
Description: The substance ml167 is a clk4 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white to gray to brown which is soluble in DMSO 10 mg/ml, clear .

ml167 (Clk4 kinase inhibitor)
SIH-505-5MG	Stressmarq	5 mg	EUR 205.2
Description: The substance ml167 is a clk4 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white to gray to brown which is soluble in DMSO 10 mg/ml, clear .

GW2580 (cFMS kinase inhibitor)
SIH-449-25MG	Stressmarq	25 mg	EUR 447.6
Description: The substance GW2580 is a cfms kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble in DMSO: 10 mg/ml, clear (warmed) .

GW2580 (cFMS kinase inhibitor)
SIH-449-5MG	Stressmarq	5 mg	EUR 168
Description: The substance GW2580 is a cfms kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble in DMSO: 10 mg/ml, clear (warmed) .

PD98059 (MEK kinase inhibitor)
SIH-466-25MG	Stressmarq	25 mg	EUR 514.8
Description: The substance PD98059 is a mek kinase inhibitor. It is synthetically produced and has a purity of ?95%. The pure substance is pale yellow solid which is soluble in DMSO (6.5 mg/ml); 25 mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6 mg/ml).

PD98059 (MEK kinase inhibitor)
SIH-466-5MG	Stressmarq	5 mg	EUR 184.8
Description: The substance PD98059 is a mek kinase inhibitor. It is synthetically produced and has a purity of ?95%. The pure substance is pale yellow solid which is soluble in DMSO (6.5 mg/ml); 25 mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6 mg/ml).

AZD6244 (ERK kinase inhibitor)
SIH-495-25MG	Stressmarq	25 mg	EUR 716.4
Description: The substance AZD6244 is a erk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white solid which is soluble in DMSO (92 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

AZD6244 (ERK kinase inhibitor)
SIH-495-5MG	Stressmarq	5 mg	EUR 252
Description: The substance AZD6244 is a erk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white solid which is soluble in DMSO (92 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

SRPIN340 (SR kinase inhibitor)
SIH-514-25MG	Stressmarq	25 mg	EUR 481.2
Description: The substance SRPIN340 is a sr kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is off-white solid which is soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl.

SRPIN340 (SR kinase inhibitor)
SIH-514-5MG	Stressmarq	5 mg	EUR 178.8
Description: The substance SRPIN340 is a sr kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is off-white solid which is soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl.

AG1296 (PDGFR kinase inhibitor)
SIH-426-25MG	Stressmarq	25 mg	EUR 608.4
Description: The substance AG1296 is a pdgfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white to brownish solid which is soluble in DMSO or dichloromethane.

AG1296 (PDGFR kinase inhibitor)
SIH-426-5MG	Stressmarq	5 mg	EUR 205.2
Description: The substance AG1296 is a pdgfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white to brownish solid which is soluble in DMSO or dichloromethane.

SU1498 (VEGFR kinase inhibitor)
SIH-480-25MG	Stressmarq	25 mg	EUR 447.6
Description: The substance SU1498 is a vegfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is solid which is soluble in DMSO .

SU1498 (VEGFR kinase inhibitor)
SIH-480-5MG	Stressmarq	5 mg	EUR 169.2
Description: The substance SU1498 is a vegfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is solid which is soluble in DMSO .

PD325901 (MEK kinase inhibitor)
SIH-507-25MG	Stressmarq	25 mg	EUR 554.4
Description: The substance PD325901 is a mek kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble to 25 mM in DMSO.

PD325901 (MEK kinase inhibitor)
SIH-507-5MG	Stressmarq	5 mg	EUR 205.2
Description: The substance PD325901 is a mek kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble to 25 mM in DMSO.

PHA 665752 (MET kinase inhibitor)
SIH-421-25MG	Stressmarq	25 mg	EUR 696
Description: The substance PHA 665752 is a met kinase inhibitor. It is synthetically produced and has a purity of >98. The pure substance is yellow solid which is soluble to 100 mM in DMSO. .

PHA 665752 (MET kinase inhibitor)
SIH-421-5MG	Stressmarq	5 mg	EUR 231.6
Description: The substance PHA 665752 is a met kinase inhibitor. It is synthetically produced and has a purity of >98. The pure substance is yellow solid which is soluble to 100 mM in DMSO. .

A83 01 (ALK kinase inhibitor)
SIH-423-25MG	Stressmarq	25 mg	EUR 514.8
Description: The substance A83 01 is a alk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige powder which is soluble to 50 mM in DMSO.

A83 01 (ALK kinase inhibitor)
SIH-423-5MG	Stressmarq	5 mg	EUR 187.2
Description: The substance A83 01 is a alk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige powder which is soluble to 50 mM in DMSO.

CID 2011756 (PKD kinase inhibitor)
SIH-438-25MG	Stressmarq	25 mg	EUR 514.8
Description: The substance CID 2011756 is a pkd kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble to 50 mM in DMSO.

CID 2011756 (PKD kinase inhibitor)
SIH-438-5MG	Stressmarq	5 mg	EUR 184.8
Description: The substance CID 2011756 is a pkd kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble to 50 mM in DMSO.

KT 5823 (PKG kinase inhibitor)
SIH-458-100UG	Stressmarq	100 µg	EUR 246
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)
SIH-458-500UG	Stressmarq	500 µg	EUR 682.8
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

NPC 15437 (PKC kinase inhibitor)
SIH-464-1MG	Stressmarq	1 mg	EUR 205.2
Description: The substance NPC 15437 is a pkc kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white solid which is soluble in water, DMSO or methanol.

NPC 15437 (PKC kinase inhibitor)
SIH-464-5MG	Stressmarq	5 mg	EUR 447.6
Description: The substance NPC 15437 is a pkc kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white solid which is soluble in water, DMSO or methanol.

Src I1 (Src kinase inhibitor)
SIH-478-25MG	Stressmarq	25 mg	EUR 399.6
Description: The substance Src I1 is a src kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (5 mg/ml).

Src I1 (Src kinase inhibitor)
SIH-478-5MG	Stressmarq	5 mg	EUR 158.4
Description: The substance Src I1 is a src kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (5 mg/ml).

GF109203X (PKC kinase inhibitor)
SIH-447-10MG	Stressmarq	10 mg	EUR 306
Description: The substance GF109203X is a pkc kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is red solid which is soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well).

GF109203X (PKC kinase inhibitor)
SIH-447-1MG	Stressmarq	1 mg	EUR 178.8
Description: The substance GF109203X is a pkc kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is red solid which is soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well).

Auranofin (IKK kinase inhibitor)
SIH-493-50MG	Stressmarq	50 mg	EUR 178.8
Description: The substance Auranofin is a ikk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (5 mg/ml) or 100% ethanol (4 mg/ml).

LY364947 (ALK5 kinase inhibitor)
SIH-504-25MG	Stressmarq	25 mg	EUR 474
Description: The substance LY364947 is a alk5 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow to brown solid which is soluble to 100 mM in DMSO.

LY364947 (ALK5 kinase inhibitor)
SIH-504-5MG	Stressmarq	5 mg	EUR 184.8
Description: The substance LY364947 is a alk5 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow to brown solid which is soluble to 100 mM in DMSO.

p21/Cyclin-Dependent Kinase Inhibitor 1
MO47036	Neuromics	100 ul	EUR 418.8

AG 1478 (EGFR kinase inhibitor)
SIH-425-25MG	Stressmarq	25 mg	EUR 474
Description: The substance AG 1478 is a egfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to light yellow solid which is soluble in DMSO (10 mg/ml).

AG 1478 (EGFR kinase inhibitor)
SIH-425-5MG	Stressmarq	5 mg	EUR 184.8
Description: The substance AG 1478 is a egfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to light yellow solid which is soluble in DMSO (10 mg/ml).

AG 1517 (EGFR kinase inhibitor)
SIH-427-25MG	Stressmarq	25 mg	EUR 541.2
Description: The substance AG 1517 is a egfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white solid which is soluble in DMSO.

AG 1517 (EGFR kinase inhibitor)
SIH-427-5MG	Stressmarq	5 mg	EUR 192
Description: The substance AG 1517 is a egfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white solid which is soluble in DMSO.

AG 879 (NGFR kinase inhibitor)
SIH-429-25MG	Stressmarq	25 mg	EUR 514.8
Description: The substance AG 879 is a ngfr kinase inhibitor. It is synthetically produced and has a purity of ?99%. The pure substance is yellow solid which is soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml).

AG 879 (NGFR kinase inhibitor)
SIH-429-5MG	Stressmarq	5 mg	EUR 182.4
Description: The substance AG 879 is a ngfr kinase inhibitor. It is synthetically produced and has a purity of ?99%. The pure substance is yellow solid which is soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml).

Bml 277 (CHK2 kinase inhibitor)
SIH-436-10MG	Stressmarq	10 mg	EUR 210
Description: The substance Bml 277 is a chk2 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).

Bml 277 (CHK2 kinase inhibitor)
SIH-436-50MG	Stressmarq	50 mg	EUR 608.4
Description: The substance Bml 277 is a chk2 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).

GW 441756 (NGFR kinase inhibitor)
SIH-450-10MG	Stressmarq	10 mg	EUR 279.6
Description: The substance GW 441756 is a ngfr kinase inhibitor. It is synthetically produced and has a purity of >99. The pure substance is red solid which is soluble to 15 mM in DMSO.

GW 441756 (NGFR kinase inhibitor)
SIH-450-50MG	Stressmarq	50 mg	EUR 877.2
Description: The substance GW 441756 is a ngfr kinase inhibitor. It is synthetically produced and has a purity of >99. The pure substance is red solid which is soluble to 15 mM in DMSO.

LFM A13 (BTK kinase inhibitor)
SIH-461-25MG	Stressmarq	25 mg	EUR 481.2
Description: The substance LFM A13 is a btk kinase inhibitor. It is synthetically produced and has a purity of ?97%. The pure substance is yellow solid which is soluble in DMSO (10 mg/ml) or ethanol (0.3 mg/ml).

LFM A13 (BTK kinase inhibitor)
SIH-461-5MG	Stressmarq	5 mg	EUR 178.8
Description: The substance LFM A13 is a btk kinase inhibitor. It is synthetically produced and has a purity of ?97%. The pure substance is yellow solid which is soluble in DMSO (10 mg/ml) or ethanol (0.3 mg/ml).

Y 27632 (ROCK kinase inhibitor)
SIH-486-1MG	Stressmarq	1 mg	EUR 178.8
Description: The substance Y 27632 is a rock kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to pale yellow powder which is soluble in DMSO (25 mg/ml), methanol (25 mg/ml), acetonitrile (<1 mg/ml), dioxan (<1 mg/ml), water (very soluble.

Y 27632 (ROCK kinase inhibitor)
SIH-486-5MG	Stressmarq	5 mg	EUR 393.6
Description: The substance Y 27632 is a rock kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to pale yellow powder which is soluble in DMSO (25 mg/ml), methanol (25 mg/ml), acetonitrile (<1 mg/ml), dioxan (<1 mg/ml), water (very soluble.

AG 494 (EGFR kinase inhibitor)
SIH-491-10MG	Stressmarq	10 mg	EUR 178.8
Description: The substance AG 494 is a egfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow solid which is soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml).

AG 494 (EGFR kinase inhibitor)
SIH-491-50MG	Stressmarq	50 mg	EUR 481.2
Description: The substance AG 494 is a egfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow solid which is soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml).

SR 3576 (JNK3 kinase inhibitor)
SIH-513-5MG	Stressmarq	5 mg	EUR 298.8
Description: The substance SR 3576 is a jnk3 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off white solid which is soluble to 100 mM in DMSO.

CHIR99021 (GSK3? kinase inhibitor)
SIH-437-1MG	Stressmarq	1 mg	EUR 151.2
Description: The substance CHIR99021 is a gsk3? kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to light brown solid which is soluble to 20 mM in DMSO.

CHIR99021 (GSK3? kinase inhibitor)
SIH-437-5MG	Stressmarq	5 mg	EUR 246
Description: The substance CHIR99021 is a gsk3? kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to light brown solid which is soluble to 20 mM in DMSO.

Gefitinib (EGFR Kinase inhibitor)
SIH-445-250MG	Stressmarq	250 mg	EUR 360
Description: The substance Gefitinib is a egfr kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is solid which is soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C).

Gefitinib (EGFR Kinase inhibitor)
SIH-445-50MG	Stressmarq	50 mg	EUR 164.4
Description: The substance Gefitinib is a egfr kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is solid which is soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C).

Axitinib (VEGFR kinase inhibitor)
SIH-494-10MG	Stressmarq	10 mg	EUR 346.8
Description: The substance Axitinib is a vegfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to tan powder which is soluble to 25 mM in DMSO.

Casein Kinase II Inhibitor IV
HY-111378	MedChemExpress	10mM/1mL	EUR 590.4

STO 609 (CAMKK kinase inhibitor)
SIH-479-25MG	Stressmarq	25 mg	EUR 474
Description: The substance STO 609 is a camkk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow solid which is soluble in DMSO (10 mg/ml).

STO 609 (CAMKK kinase inhibitor)
SIH-479-5MG	Stressmarq	5 mg	EUR 181.2
Description: The substance STO 609 is a camkk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow solid which is soluble in DMSO (10 mg/ml).

ZM 306416 (VEGFR kinase inhibitor)
SIH-487-25MG	Stressmarq	25 mg	EUR 474
Description: The substance ZM 306416 is a vegfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (3 mg/ml) or ethanol (1 mg/ml).

ZM 306416 (VEGFR kinase inhibitor)
SIH-487-5MG	Stressmarq	5 mg	EUR 178.8
Description: The substance ZM 306416 is a vegfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (3 mg/ml) or ethanol (1 mg/ml).

Ruxolitinib (JAK kinase inhibitor)
SIH-509-25MG	Stressmarq	25 mg	EUR 750
Description: The substance Ruxolitinib is a jak kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is off-white solid which is soluble in DMSO (25 mg/ml) or EtOH (~15 mg/ml).

Ruxolitinib (JAK kinase inhibitor)
SIH-509-5MG	Stressmarq	5 mg	EUR 285.6
Description: The substance Ruxolitinib is a jak kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is off-white solid which is soluble in DMSO (25 mg/ml) or EtOH (~15 mg/ml).

AG490 (JAK-2 kinase inhibitor)
SIH-428-25MG	Stressmarq	25 mg	EUR 339.6
Description: The substance AG490 is a jak-2 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is tan solid which is soluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml).

AG490 (JAK-2 kinase inhibitor)
SIH-428-5MG	Stressmarq	5 mg	EUR 158.4
Description: The substance AG490 is a jak-2 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is tan solid which is soluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml).

WHI P131 (JAK3 kinase inhibitor)
SIH-485-10MG	Stressmarq	10 mg	EUR 178.8
Description: The substance WHI P131 is a jak3 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white solid which is soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml).

WHI P131 (JAK3 kinase inhibitor)
SIH-485-50MG	Stressmarq	50 mg	EUR 460.8
Description: The substance WHI P131 is a jak3 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white solid which is soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml).

Apigenin (Protein kinase inhibitor)
SIH-249-10MG	Stressmarq	10 mg	EUR 127.2
Description: The substance Apigenin is a protein kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 50 mM in DMSO.

Apigenin (Protein kinase inhibitor)
SIH-249-50MG	Stressmarq	50 mg	EUR 255.6
Description: The substance Apigenin is a protein kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 50 mM in DMSO.

ATM Kinase Inhibitor, KU-55933
1685-5	Biovision	each	EUR 288

Adenosine Kinase Inhibitor (hydrate)
C5282-1	ApexBio	1 mg	EUR 134.4
Description: IC50: 1.7 nM in cell-free assaysAdenosine Kinase Inhibitor is an inhibitor of adenosine kinase. Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations.

Adenosine Kinase Inhibitor (hydrate)
C5282-10	ApexBio	10 mg	EUR 435.6
Description: IC50: 1.7 nM in cell-free assaysAdenosine Kinase Inhibitor is an inhibitor of adenosine kinase. Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations.

Adenosine Kinase Inhibitor (hydrate)
C5282-5	ApexBio	5 mg	EUR 360
Description: IC50: 1.7 nM in cell-free assaysAdenosine Kinase Inhibitor is an inhibitor of adenosine kinase. Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations.

Diacylglycerol Kinase Inhibitor I
50R-R59022	Fitzgerald	50 mg	EUR 289.2
Description: Diacylglycerol Kinase Inhibitor I chemical reference substance

Dorsomorphin (AMPK kinase inhibitor)
SIH-443-25MG	Stressmarq	25 mg	EUR 514.8
Description: The substance Dorsomorphin is a ampk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow solid which is soluble in DMSO (4 mg/ml, warm).

Dorsomorphin (AMPK kinase inhibitor)
SIH-443-5MG	Stressmarq	5 mg	EUR 184.8
Description: The substance Dorsomorphin is a ampk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow solid which is soluble in DMSO (4 mg/ml, warm).

Imatinib mesylate (Kinase inhibitor)
SIH-453-100MG	Stressmarq	100 mg	EUR 279.6
Description: The substance Imatinib mesylate is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble H2O: soluble10 mg/ml, clear .

Imatinib mesylate (Kinase inhibitor)
SIH-453-20MG	Stressmarq	20 mg	EUR 151.2
Description: The substance Imatinib mesylate is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble H2O: soluble10 mg/ml, clear .

BAY 11 7082 (IKK kinase inhibitor)
SIH-434-10MG	Stressmarq	10 mg	EUR 184.8
Description: The substance BAY 11 7082 is a ikk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in ethanol and to 100 mM in DMSO.

BAY 11 7082 (IKK kinase inhibitor)
SIH-434-50MG	Stressmarq	50 mg	EUR 507.6
Description: The substance BAY 11 7082 is a ikk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in ethanol and to 100 mM in DMSO.

PX 866 (PI 3-Kinase inhibitor)
SIH-471-1MG	Stressmarq	1 mg	EUR 178.8
Description: The substance PX 866 is a pi 3-kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO at 200 mg/ml; soluble in ethanol at 200 mg/ml; very poorly soluble in water.

PX 866 (PI 3-Kinase inhibitor)
SIH-471-5MG	Stressmarq	5 mg	EUR 298.8
Description: The substance PX 866 is a pi 3-kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO at 200 mg/ml; soluble in ethanol at 200 mg/ml; very poorly soluble in water.

LY 294002 (PI 3-Kinase inhibitor)
SIH-252-25MG	Stressmarq	25 mg	EUR 532.8
Description: The substance LY 294002 is a pi 3-kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white crystalline solid which is soluble to 5 mM in ethanol and to 25 mM in DMSO.