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Oplosbare Antibody Stimulatieter onthuld door BOOST fosfotyrosine Proteomics

Chimère  antigeen  receptor  T-cellen (CAR-T-cellen) de toekomst in immunotherapie voor auto-immuunziekten?

Doelstelling:  CAR-T-celtherapie heeft een revolutie teweeggebracht in de behandeling van oncologische ziekten en recentelijk zijn mogelijke toepassingen bij auto-immuunziekten beschreven. De beoordeling heeft tot doel de beschikbare gegevens over de behandeling met CAR-T-cellen te integreren, met de nadruk op auto-immuunziekten, om de therapeutische vooruitgang en hun mogelijke toekomstige klinische toepasbaarheid bij auto-immuniteit te bepalen.

Materialen en methoden:  Er is gezocht in PubMed met de trefwoorden “Chimeric Antigen Receptor” en “CART cell”. De relevante documenten werden geselecteerd en de informatie werd kritisch bekeken.

Resultaten:  Bij de behandeling van auto-immuunziekten zijn in preklinische modellen drie verschillende cellulaire strategieën gebruikt, waaronder chimere antigeenreceptor T-cellen, chimere auto-antilichaamreceptor T-cellen en chimere antigeenreceptor in regulerende T-lymfocyten . Alle drie soorten therapie zijn effectief geweest. De mogelijke nadelige effecten daarin, het cytokine-afgiftesyndroom, cellulaire toxiciteit en neurotoxiciteit moeten altijd in gedachten worden gehouden.

Conclusies:  Hoewel er nog geen informatie over mensen beschikbaar is, laten preklinische modellen van CAR-T-cellen bij de behandeling van auto-immuunziekten veelbelovende resultaten zien, zodat ze in de toekomst een nuttige en effectieve therapie kunnen worden bij de behandeling van deze pathologieën.

Ovalbumine  Antigen -Specifieke Activatie van menselijke T-cel  -receptor  lijkt sterk op Oplosbare Antibody Stimulatieter onthuld door BOOST fosfotyrosine Proteomics

Activering van de T-celreceptor (TCR) leidt tot een netwerk van vroege signalering, voornamelijk georkestreerd door tyrosinefosforylering in T-cellen. De TCR wordt gewoonlijk geactiveerd met behulp van oplosbare anti-TCR-antilichamen, maar deze benadering is niet antigeenspecifiek. Als alternatief wordt aangenomen dat het activeren van de TCR met behulp van specifieke antigenen met een reeks bindingsaffiniteiten in de vorm van een peptide-major histocompatibiliteitscomplex (pMHC) meer fysiologisch is. Vanwege het ontbreken van grootschalige fosfotyrosine (pTyr) proteomische onderzoeken die anti-TCR-antilichamen en pMHC rechtstreeks vergelijken, blijft een uitgebreide definitie van deze geactiveerde toestanden echter raadselachtig.

Opheldering van het tyrosinefosfoproteoom met behulp van kwantitatieve pTyr-proteomics maakt een beter begrip mogelijk van de unieke kenmerken van deze activerende middelen en de rol van ligandbindingsaffiniteit op signalering. Hier passen we de latest opgerichte breedspectrumoptimalisatie van selectieve triggering (BOOST) toe om verstoringen in tyrosinefosforylering van menselijke TCR te onderzoeken, veroorzaakt door anti-TCR-antilichamen en pMHC. Onze gegevens laten zien dat pMHC-activering met hoge affiniteit ovalbumine (OVA) van de menselijke TCR een grotendeels vergelijkbare, zij het mogelijk sterkere, pTyr-gemedieerdesignaalregulerende as vergeleken met het anti-TCR-antilichaam. De signaleringsoutput die resulteert uit OVA pMHC-varianten correleert goed met hun zwakkere affiniteiten, waardoor affiniteit-afstembare controle van de signaalsterkte mogelijk is. Gezamenlijk bieden we een raamwerk voor het toepassen van BOOST om pTyr-gemedieerde signaalroutes van menselijke T-cellen te vergelijken die op een antigeenonafhankelijke en antigeenspecifieke manier zijn geactiveerd.

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tminederland

HIV-1 p24 recombinant antigen.

MBS485187-01mg 0.1mg
EUR 300

HIV-1 p24 recombinant antigen.

MBS485187-1mg 1mg
EUR 1300

HIV-1 p24 recombinant antigen.

MBS485187-5x1mg 5x1mg
EUR 5795

HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations)

0801002 96T
EUR 657.79
Description: Please contact Gentaur in order to receive the datasheet of the product.

HIV-1 gag p24 antigen (RECOMBINANT)

HI1A-720-4 50ug
EUR 295

HIV-1 gag p24 antigen (RECOMBINANT)

HI1A-720-5 100ug
EUR 495

HIV-P24 antigen array kit

VArk-Lsx001 unit Ask for price
Description: Fourth-generation HIV immunoassays detect viral p24 protein in the blood.

Human HIV-1 And HIV-2 Antibodies Plus P24 Antigen Fourth-Generation ELISA Kit

abx257575-05mg 0.5 mg Ask for price

Human HIV-1 And HIV-2 Antibodies Plus P24 Antigen Fourth-Generation ELISA Kit

abx257575-100g 100 µg
EUR 468.75

Human HIV-1 And HIV-2 Antibodies Plus P24 Antigen Fourth-Generation ELISA Kit

abx257575-1mg 1 mg Ask for price

Recombinant HIV-1 p24 Core Antigen

HIV-277 1 vial
EUR 798.4
Description: Protein

HIV-1 p17-p24 recombinant antigen.

00172-V 1 MG
EUR 850

HIV-1 p17-p24 recombinant antigen.

00172-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 p17-p24 recombinant antigen.

HIV-1 p17-p24 recombinant antigen.

MBS485154-01mg 0.1mg
EUR 300

HIV-1 p17-p24 recombinant antigen.

MBS485154-1mg 1mg
EUR 1300

HIV-1 p17-p24 recombinant antigen.

MBS485154-5x1mg 5x1mg
EUR 5795

Antibody against HIV P24 antigen

MBS478168-10mg 10mg
EUR 1560

Antibody against HIV P24 antigen

MBS478168-1mg 1mg
EUR 275

Antibody against HIV P24 antigen

MBS478168-20mg 20mg
EUR 2570

Antibody against HIV P24 antigen

MBS478168-50mg 50mg
EUR 6185

Antibody against HIV P24 antigen

MBS478168-5mg 5mg
EUR 840

Antibody against HIV P24 antigen

MBS478169-10mg 10mg
EUR 1560

Antibody against HIV P24 antigen

MBS478169-1mg 1mg
EUR 275

Antibody against HIV P24 antigen

MBS478169-20mg 20mg
EUR 2570

Antibody against HIV P24 antigen

MBS478169-50mg 50mg
EUR 6185

Antibody against HIV P24 antigen

MBS478169-5mg 5mg
EUR 840

Antibody against HIV P24 antigen

MBS478170-10mg 10mg
EUR 1560

Antibody against HIV P24 antigen

MBS478170-1mg 1mg
EUR 275

Antibody against HIV P24 antigen

MBS478170-20mg 20mg
EUR 2570

Antibody against HIV P24 antigen

MBS478170-50mg 50mg
EUR 6185

Antibody against HIV P24 antigen

MBS478170-5mg 5mg
EUR 840

Antibody against HIV P24 antigen

MBS478171-10mg 10mg
EUR 1560

Antibody against HIV P24 antigen

MBS478171-1mg 1mg
EUR 275

Antibody against HIV P24 antigen

MBS478171-20mg 20mg
EUR 2570

Antibody against HIV P24 antigen

MBS478171-50mg 50mg
EUR 6185

Antibody against HIV P24 antigen

MBS478171-5mg 5mg
EUR 840

HIV-1 GAG P24 Recombinant Antigen

00111-V-01mg 0,1 mg
EUR 321
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen

00111-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV 1 p24 core recombinant antigen.

00177-V 1 MG
EUR 850

HIV 1 p24 core recombinant antigen

00177-V-01mg 0,1 mg
EUR 321
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen

00177-V-1000ug 1000 ug
EUR 1539
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen.

00177-V-100ugvial 100ug/vial
EUR 150
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen.

MBS485109-01mg 0.1mg
EUR 300

HIV 1 p24 core recombinant antigen.

MBS485109-1mg 1mg
EUR 1300

HIV 1 p24 core recombinant antigen.

MBS485109-5x1mg 5x1mg
EUR 5795

HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations)

0801200 5 X 96T
EUR 2563

HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations)

801200 5 X 96 Determinations
EUR 2563

Recombinant HIV-1 p24 Antigen, His-tagged

HIV-276 1 vial
EUR 798.4
Description: Protein

Recombinant HIV-1 p24 Antigen, His-tagged

HIV-281 1 vial
EUR 798.4
Description: Protein

HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations)

0801008 5 X 96T
EUR 2505

Human HIV(1+2 antibodies plus p24 antigen (4th Generation) ELISA Kit

EH4101 96T
EUR 571.5
Description: Method of detection: Qualitative ;Reacts with: Homo sapiens;Sensitivity: Qualitative

Mouse Anti Human Immunodeficiency Virus (HIV-1) p24 (1947)

MAB12321-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for HIV-1 p24

Mouse Anti Human Immunodeficiency Virus (HIV-1) p24 (1947)

MAB12321-500 0.5
EUR 671.04
Description: Mouse monoclonal antibody specific for HIV-1 p24

HIV-1 gag p24 antigen IgG fraction (monoclonal)

HI1M-721-5 100ug
EUR 425

Human Immunodeficiency Virus (HIV) p24 Antigen >95%

MBS568670-1mg 1mg
EUR 2175

Human Immunodeficiency Virus (HIV) p24 Antigen >95%

MBS568670-5x1mg 5x1mg
EUR 9585

Recombinant HIV-1 p24 Antigen, GST-tagged, HRP-Labled

HIV-282 1 vial
EUR 798.4
Description: Protein

Rat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614549-10x96StripWells 10x96-Strip-Wells
EUR 3290

Rat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614549-48StripWells 48-Strip-Wells
EUR 295

Rat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614549-5x96StripWells 5x96-Strip-Wells
EUR 1800

Rat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614549-96StripWells 96-Strip-Wells
EUR 450

Goat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614545-10x96StripWells 10x96-Strip-Wells
EUR 3545

Goat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614545-48StripWells 48-Strip-Wells
EUR 310

Goat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614545-5x96StripWells 5x96-Strip-Wells
EUR 1940

Goat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614545-96StripWells 96-Strip-Wells
EUR 475

Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

NSL1389Hu 96 wells
EUR 468

Mouse HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614547-10x96StripWells 10x96-Strip-Wells
EUR 3290

Mouse HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614547-48StripWells 48-Strip-Wells
EUR 295

Mouse HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614547-5x96StripWells 5x96-Strip-Wells
EUR 1800

Mouse HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614547-96StripWells 96-Strip-Wells
EUR 450

Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2602892-10x96StripWells 10x96-Strip-Wells
EUR 3040

Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2602892-48StripWells 48-Strip-Wells
EUR 285

Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2602892-5x96StripWells 5x96-Strip-Wells
EUR 1670

Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2602892-96StripWells 96-Strip-Wells
EUR 405

Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

EIA06774h each
EUR 430

Bovine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2610168-10x96StripWells 10x96-Strip-Wells
EUR 3545

Bovine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2610168-48StripWells 48-Strip-Wells
EUR 310

Bovine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2610168-5x96StripWells 5x96-Strip-Wells
EUR 1940

Bovine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2610168-96StripWells 96-Strip-Wells
EUR 475

Canine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614543-10x96StripWells 10x96-Strip-Wells
EUR 3545

Canine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614543-48StripWells 48-Strip-Wells
EUR 310

Canine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614543-5x96StripWells 5x96-Strip-Wells
EUR 1940

Canine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614543-96StripWells 96-Strip-Wells
EUR 475

Rabbit HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614550-10x96StripWells 10x96-Strip-Wells
EUR 3545

Rabbit HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614550-48StripWells 48-Strip-Wells
EUR 310

Rabbit HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614550-5x96StripWells 5x96-Strip-Wells
EUR 1940

Rabbit HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614550-96StripWells 96-Strip-Wells
EUR 475

Chicken HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614544-10x96StripWells 10x96-Strip-Wells
EUR 3545

Chicken HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614544-48StripWells 48-Strip-Wells
EUR 310

Chicken HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614544-5x96StripWells 5x96-Strip-Wells
EUR 1940

Chicken HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614544-96StripWells 96-Strip-Wells
EUR 475

Porcine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614548-10x96StripWells 10x96-Strip-Wells
EUR 3545

Porcine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614548-48StripWells 48-Strip-Wells
EUR 310

Porcine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614548-5x96StripWells 5x96-Strip-Wells
EUR 1940

Porcine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614548-96StripWells 96-Strip-Wells
EUR 475

Recombinant HIV-1 gag p17 and p24 Antigen, GST-tagged

PT2-332 1 vial
EUR 798.4
Description: Protein

Recombinant HIV-1 p24 gag Antigen, beta-galactosidase-tagged

HIV-278 1 vial
EUR 798.4
Description: Protein

Human Immunodeficiency Virus p24 Protein [HIV-1/Clade B]

REC31743-100 0.1
EUR 496.27
Description: Recombinant HIV p24 protein (NCBI accession number ABO61536, AA35-265, L40I) produced in HEK293 cells. Protein carries a C-terminal His-tag.. Protein was purified by immobilised metal affinity and ion exchange chromatography from the pellet of transfected cells.

Human Immunodeficiency Virus p24 Protein [HIV-1/Clade B]

REC31743-500 0.5
EUR 1363.78
Description: Recombinant HIV p24 protein (NCBI accession number ABO61536, AA35-265, L40I) produced in HEK293 cells. Protein carries a C-terminal His-tag.. Protein was purified by immobilised metal affinity and ion exchange chromatography from the pellet of transfected cells.

Human Immunodeficiency Virus P24 Protein [HIV-1/Clade C]

REC31706-100 0.1
EUR 457.08
Description: Recombinant HIV-1 p24 produced in E. coli with a 6x histidine tag.

Human Immunodeficiency Virus P24 Protein [HIV-1/Clade C]

REC31706-500 0.5
EUR 1167.82
Description: Recombinant HIV-1 p24 produced in E. coli with a 6x histidine tag.

Bovine HIV-1 p24 core protein(HIV-1 p24) Anti-body ELISA Kit

NSL1181Bo 96 T
EUR 528

Guinea pig HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614546-10x96StripWells 10x96-Strip-Wells
EUR 3545

Guinea pig HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614546-48StripWells 48-Strip-Wells
EUR 310

Guinea pig HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614546-5x96StripWells 5x96-Strip-Wells
EUR 1940

Guinea pig HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

MBS2614546-96StripWells 96-Strip-Wells
EUR 475

HIV-1 p24 ELISA Kit

Z7040001 1 kit
EUR 865

HIV-1 p24 ELISA Kit

MBS412756-5x960Tests 5x960Tests
EUR 17580

HIV-1 p24 ELISA Kit

MBS412756-960Tests 960Tests
EUR 3770

HIV-1 p24 ELISA Kit

MBS412756-96Tests 96Tests
EUR 510

Recombinant HIV-1 p24 Antigen, beta-galactosidase-tagged, Biotin-Labled

HIV-280 1 vial
EUR 798.4
Description: Protein

Recombinant HIV-1 gag p17-p24 and gp41-gp120 Antigen

VAC-0333 0.5ml
EUR 1598.4
Description: Protein

OPEF01414-1MG - Recombinant Human Immunodeficiency Virus 1 (HIV 1-p24) Antigen

OPEF01414-1MG 1mg
EUR 2216

Recombinant HIV-1 gag p17, p24 and gp120 Antigen, GST-tagged

THP-0332 1 vial
EUR 2398.4
Description: Protein

Human HIV (1+2) antigen&antibody ELISA Kit

EK11777 96Т
EUR 799

Human HIV (1+2) antigen&antibody ELISA Kit

AE62582HU-48Tests 48 Tests
EUR 360
Description: Human (Homo sapiens)

Human HIV (1+2) antigen&antibody ELISA Kit

AE62582HU-96Tests 96 Tests
EUR 680
Description: Human (Homo sapiens)

Human HIV (1+2) antigen&antibody ELISA Kit

AE62582HU-48T 48T
EUR 360
Description: Human (Homo sapiens)

Human HIV (1+2) antigen&antibody ELISA Kit

AE62582HU-96T 96T
EUR 680
Description: Human (Homo sapiens)

Human HIV (1+2) antigen&antibody ELISA Kit

MBS2800305-10x96StripWells 10x96-Strip-Wells
EUR 6840

Human HIV (1+2) antigen&antibody ELISA Kit

MBS2800305-48StripWells 48-Strip-Wells
EUR 480

Human HIV (1+2) antigen&antibody ELISA Kit

MBS2800305-5x96StripWells 5x96-Strip-Wells
EUR 3610

Human HIV (1+2) antigen&antibody ELISA Kit

MBS2800305-96StripWells 96-Strip-Wells
EUR 805

Human HIV (1+2) Antigen & Antibody ELISA Kit

MBS3802470-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human HIV (1+2) Antigen & Antibody ELISA Kit

MBS3802470-48StripWells 48-Strip-Wells
EUR 550

Human HIV (1+2) Antigen & Antibody ELISA Kit

MBS3802470-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human HIV (1+2) Antigen & Antibody ELISA Kit

MBS3802470-96StripWells 96-Strip-Wells
EUR 765

HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

00111-V 1 MG
EUR 850

HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

00111-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

MBS485158-01mg 0.1mg
EUR 300

HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

MBS485158-1mg 1mg
EUR 1300

HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

MBS485158-5x1mg 5x1mg
EUR 5795

Extended Range HIV-1 p24 ELISA Kit

MBS412758-5x96Samples 5x96Samples
EUR 2575

Extended Range HIV-1 p24 ELISA Kit

MBS412758-96Samples 96Samples
EUR 560

HIV-1 p24 (group O, strain BCF06) Antibody, Rabbit Pab, Antigen Affinity Purified

MBS8119499-002mL 0.02mL
EUR 185

HIV-1 p24 (group O, strain BCF06) Antibody, Rabbit Pab, Antigen Affinity Purified

MBS8119499-01mL 0.1mL
EUR 385

HIV-1 p24 (group O, strain BCF06) Antibody, Rabbit Pab, Antigen Affinity Purified

MBS8119499-5x01mL 5x0.1mL
EUR 1590

HIV-1 p17/24/gp120 antigen

00169-V-01mg 0,1 mg
EUR 321
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

HIV-1 p17/24/gp120 antigen

00169-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

HIV-1 nef antigen

GWB-633F8F 0.5 mg Ask for price

HIV-1 gag p17 antigen (RECOMBINANT)

HI1A-710-4 50ug
EUR 295

HIV-1 gag p17 antigen (RECOMBINANT)

HI1A-710-5 100ug
EUR 495

HIV-1 gag p55 antigen (RECOMBINANT)

HI1A-730-4 50ug
EUR 295

HIV-1 gag p55 antigen (RECOMBINANT)

HI1A-730-5 100ug
EUR 495

Recombinant HIV-1 p55 gag Antigen

HIV-283 1 vial
EUR 798.4
Description: Protein

Recombinant HIV-1 p66 pol Antigen

HIV-284 1 vial
EUR 798.4
Description: Protein

HIV-1 p24 (HIV-1)

GWB-420F7B 0.1 mg Ask for price

HIV-1 envelope p31 antigen (RECOMBINANT)

HI1A-700-4 50ug
EUR 295

HIV-1 envelope p31 antigen (RECOMBINANT)

HI1A-700-5 100ug
EUR 495

HIV-1 intergase antigen

00199-V-01mg 0,1 mg
EUR 321
Description: HIV-1 intergase antigen. The protein contains the HIV-1 immunodominant regions from pol protein (integrase).

HIV-1 intergase antigen

00199-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 intergase antigen. The protein contains the HIV-1 immunodominant regions from pol protein (integrase).

HIV-1 (group M, subtype B, strain 92418) p24 Antibody, Rabbit PAb, Antigen Affinity Purified

MBS8105664-002mL 0.02mL
EUR 185

HIV-1 (group M, subtype B, strain 92418) p24 Antibody, Rabbit PAb, Antigen Affinity Purified

MBS8105664-01mL 0.1mL
EUR 385

HIV-1 (group M, subtype B, strain 92418) p24 Antibody, Rabbit PAb, Antigen Affinity Purified

MBS8105664-5x01mL 5x0.1mL
EUR 1590

HIV-1 Recombinant antigen

MBS320616-01mg 0.1mg
EUR 440

HIV-1 Recombinant antigen

MBS320616-5x01mg 5x0.1mg
EUR 1885

HIV-1 Recombinant antigen

MBS320617-01mg 0.1mg
EUR 440

HIV-1 Recombinant antigen

MBS320617-5x01mg 5x0.1mg
EUR 1885

HIV-1 Recombinant antigen

MBS320618-01mg 0.1mg
EUR 630

HIV-1 Recombinant antigen

MBS320618-5x01mg 5x0.1mg
EUR 2745

HIV-1 p24 Antibody

20-abx137062
  • Ask for price
  • Ask for price
  • 0.5 mg
  • 1 mg

HIV-1 p24 Antibody

abx023925-1mg 1 mg
EUR 828

HIV-1 p24 Antibody

abx023926-1mg 1 mg
EUR 828

HIV-1 p24 Antibody

abx021869-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021870-1mg 1 mg
EUR 760.8

HIV-1 p24 Antibody

abx021871-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021872-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021873-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021882-1mg 1 mg
EUR 1178.4

HIV-1 p24 Antibody

abx021883-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx021886-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx021887-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx021888-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx023027-1ml 1 ml
EUR 693.6

HIV-1 p24 Antibody

7313-002mg 0.02 mg
EUR 206.18
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains.

HIV-1 p24 Antibody

7313-01mg 0.1 mg
EUR 523.7
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains.

HIV-1 p24, Antibody

GWB-3B2FFB 1 mg Ask for price

HIV-1 p24 Antibody

GWB-26647C 0.1 mg Ask for price

HIV-1 p24, Antibody

GWB-2D04FA 0.1 mg Ask for price

HIV-1 p24, Antibody

GWB-2DD7E0 0.1 mg Ask for price

HIV-1 p24, Antibody

GWB-192382 0.1 mg Ask for price

HIV-1 p24 Antibody

GWB-846CEC 1 ml Ask for price

HIV-1 p24, Antibody

GWB-9C0291 0.1 mg Ask for price

HIV-1 p24 Antibody

GWB-9EAC4B 1 ml Ask for price

HIV-1 p24 Antibody

GWB-4CB110 1 ml Ask for price

HIV-1 p24 Antibody

GWB-76A9C7 0.1 mg Ask for price

HIV-1 p24 Antibody

GWB-F48F6D 0.1 mg Ask for price

HIV-1 p24, Antibody

GWB-B0158C 0.1 mg Ask for price

HIV-1 p24 Antibody

GWB-BBDE10 1 ml Ask for price

HIV-1 p24 Antibody

GWB-F1D71D 0.1 mg Ask for price

Bilaterale anterior cerebrale slagader occlusie na CD19- en BCMA-gerichte chimere  antigeen  receptor  van T-celtherapie voor een patiënt myeloom

Chimere antigeenreceptor T (CAR-T)-celtherapie is een veelbelovende behandeling voor recidiverend/refractair multipel myeloom (RRMM). In ons vorige rapport was CD19- en BCMA-gerichte gelijktijdige toediening van CAR-T geassocieerd met een hoog responspercentage. Hoewel cytokine launch syndrome (CRS) en neurotoxiciteit frequente complicaties zijn na behandeling met CAR-T, wordt een herseninfarct zelden gerapporteerd als een CAR-T-gerelateerde complicatie. We rapporteerden een 73-jarige vrouwelijke MM-patiënt die CD19- en BCMA-gerichte CAR-T ontving voor refractaire ziekte.

Haar ziekte reageerde op CAR-T- therapie, maar ze ontwikkelde neurologische symptomen na CRS. Craniale CT en MRI toonden meerdere herseninfarcten en bilaterale anterieure cerebrale arterie (ACA) occlusie aan. We suggereren dat een ander herseninfarct dan CAR-T-gerelateerde neurotoxiciteit de onderliggende oorzaak is van abnormale neuropsychologische symptomen, en diagnostische beeldvormingstests moeten actief worden uitgevoerd om ischemische cerebrovasculaire gebeurtenissen uit te sluiten.

Het intracellulaire domein van CD40 is een krachtige Costimulatoire Ingredient in chimère  Antigen  Receptoren

De co-stimulerende domeinen die zijn ingebouwd in chimere antigeenreceptoren (CAR’s) van de tweede generatie en de derde generatie, hebben een sterke invloed op de functie van CAR-T-cellen . Hier hebben we CAR’s van de tweede generatie en de derde generatie onderzocht die het signaleringsdomein van de CD40-receptor herbergen als een nieuw costimulerend component in vergelijking met vergelijkbare CAR’s die het 4-1BB-domein dragen . In CAR’s van beide generaties was CD40 krachtiger dan 4-1BB bij het triggeren van de NF-KB-signaleringsroute.

In humane T-cellen van 2 donoren was CD40 vergelijkbaar met 4-1BB bij het opreguleren van co-stimulerende en activatiemarkers, het induceren van pro-inflammatoire cytokinesecretie en het mediëren van het doden van doelwitcellen. Interessant genoeg waren er duidelijk verschillen in het responspatroon van T-cellen van de 2 donoren met betrekking tot CD40 en 4-1BB. We concluderen dat in menselijke T-cellen het CD40- signaleringsdomein een krachtig co-stimulerend component is in CAR’s van zowel de tweede generatie als de derde generatie.

Een systematische herziening van de rol van chimere  Antigeen  Receptor  T (CAR-T) celtherapie bij de behandeling van solide tumoren

Chimere antigeenreceptor T (CAR-T) celtherapie maakt gebruik van de eigen T-lymfocyten van de patiënt die zijn ontworpen om kankercellen aan te vallen. Het is door de Meals and Drug Administration (FDA) goedgekeurd voor verschillende hematologische maligniteiten en wordt momenteel geëvalueerd bij solide kankers in vroege fase-onderzoeken. We deden een systematische evaluate bestaande uit 15 prospectieve klinische onderzoeken (n = 159) die CAR-T-cellen in solide kankers evalueerden . Vroege fase-onderzoeken toonden veelbelovende responspercentages bij ovariumepitheelkanker (100%), humaan epidermale groeifactorreceptor  (HER2)-positief sarcoom (67%) , epidermale groeifactorreceptor (EGFR)-positieve galwegkanker (65%), gevorderde maag-/pancreaskanker (82%), hepatocellulair carcinoom (67%),en colorectale kanker (70%) .

De mediane algehele respons voor alle maligniteiten was 62% (bereik 17%-100%) . De mediane progressievrije overleving en de totale overleving werden in de meeste onderzoeken niet bereikt. Cytokine-afgiftesyndroom werd gezien bij slechts één patiënt met cholangiocarcinoom die EGFR-specifieke CAR-T-celtherapie kreeg. Hoewel de overlevingsgegevens nog steeds niet volgroeid zijn, liet CAR-T-celtherapie bij solide maligniteiten bemoedigende responspercentages zien en werd goed verdragen.

Verschillen in lymfoompatiënten tussen chimeer  antigeen  receptor  van T-cel therapeutische proeven en bevolking

Chimere antigeenreceptor (CAR)-T-celtherapieën lijken veelbelovende behandelingen te zijn voor non-Hodgkin- en B-cellymfoom. Verschillende CAR-T-therapieën die zijn goedgekeurd door de Amerikaanse Meals and Drug Administration, zijn echter alleen op werkzaamheid getest in relatief weinig klinische onderzoeken met een enkele arm met kleine steekproefomvang. We probeerden de verschillen tussen patiënten in deze onderzoeken en de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom te onderzoeken. Vijfhonderdtweeëntwintig patiënten uit 15 CAR-T-onderzoeken gevonden in een systematische evaluate en 417.492 patiënten uit de Surveillance, Epidemiology, and Finish Outcomes (SEER) Program-database werden vergeleken.

De deelnemers aan de CAR-T-studie leken jonger (46,7% jonger dan 70 jaar vs. 42,2%) , meer mannelijk (68,0% vs. 55,7%) en werden gedurende een kortere periode gevolgd in vergelijking met patiënten in de SEER-populatie (gemiddelde [M] 45,6 maanden, 95% betrouwbaarheidsinterval [BI] 17,7 tot 63,three maanden follow-up vs. M 57,1 maanden, 95% BI 57,Zero tot 57,three maanden overleving). Deelnemers aan de CAR-T-studie kunnen aanzienlijk verschillen van de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom . De effectiviteit van CAR-T-therapieën bij de algemene populatie van lymfoompatiënten kan verschillen van de effectiviteit die is aangetoond in onderzoeken. Nieuw gecreëerde CAR-T-patiëntenregisters zijn essentieel om de effectiviteit van de therapieën op populatieniveau huge te stellen.

 

ALK kinase inhibitor-1

T6409-10mg 10mg Ask for price
Description: ALK kinase inhibitor-1

ALK kinase inhibitor-1

T6409-1g 1g Ask for price
Description: ALK kinase inhibitor-1

ALK kinase inhibitor-1

T6409-1mg 1mg Ask for price
Description: ALK kinase inhibitor-1

ALK kinase inhibitor-1

T6409-50mg 50mg Ask for price
Description: ALK kinase inhibitor-1

ALK kinase inhibitor-1

T6409-5mg 5mg Ask for price
Description: ALK kinase inhibitor-1

ALK kinase inhibitor-1

HY-19990 10 mg
EUR 211.04
Description: ALK kinase inhibitor-1 is an anaplastic lymphoma kinase (ALK) inhibitor extracted from patent US20130261106A1 compound I-202[1].

TAO Kinase inhibitor 1

HY-112136 50mg
EUR 955.2

TAO Kinase inhibitor 1

T16987-10mg 10mg Ask for price
Description: TAO Kinase inhibitor 1

TAO Kinase inhibitor 1

T16987-1g 1g Ask for price
Description: TAO Kinase inhibitor 1

TAO Kinase inhibitor 1

T16987-1mg 1mg Ask for price
Description: TAO Kinase inhibitor 1

TAO Kinase inhibitor 1

T16987-50mg 50mg Ask for price
Description: TAO Kinase inhibitor 1

TAO Kinase inhibitor 1

T16987-5mg 5mg Ask for price
Description: TAO Kinase inhibitor 1

TAO Kinase inhibitor 1

MBS5755584-10mg 10mg
EUR 195

TAO Kinase inhibitor 1

MBS5755584-25mg 25mg
EUR 300

TAO Kinase inhibitor 1

MBS5755584-2mg 2mg
EUR 145

TAO Kinase inhibitor 1

MBS5755584-50mg 50mg
EUR 460

TAO Kinase inhibitor 1

MBS5755584-5mg 5mg
EUR 160

Tpl2 Kinase Inhibitor 1

T17145-10mg 10mg Ask for price
Description: Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1

T17145-1g 1g Ask for price
Description: Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1

T17145-1mg 1mg Ask for price
Description: Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1

T17145-50mg 50mg Ask for price
Description: Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1

T17145-5mg 5mg Ask for price
Description: Tpl2 Kinase Inhibitor 1

RIP1 kinase inhibitor 1

T12725-10mg 10mg Ask for price
Description: RIP1 kinase inhibitor 1

RIP1 kinase inhibitor 1

T12725-1g 1g Ask for price
Description: RIP1 kinase inhibitor 1

RIP1 kinase inhibitor 1

T12725-1mg 1mg Ask for price
Description: RIP1 kinase inhibitor 1

RIP1 kinase inhibitor 1

T12725-50mg 50mg Ask for price
Description: RIP1 kinase inhibitor 1

RIP1 kinase inhibitor 1

T12725-5mg 5mg Ask for price
Description: RIP1 kinase inhibitor 1

RIP2 kinase inhibitor 1

T12727-10mg 10mg Ask for price
Description: RIP2 kinase inhibitor 1

RIP2 kinase inhibitor 1

T12727-1g 1g Ask for price
Description: RIP2 kinase inhibitor 1

RIP2 kinase inhibitor 1

T12727-1mg 1mg Ask for price
Description: RIP2 kinase inhibitor 1

RIP2 kinase inhibitor 1

T12727-50mg 50mg Ask for price
Description: RIP2 kinase inhibitor 1

RIP2 kinase inhibitor 1

T12727-5mg 5mg Ask for price
Description: RIP2 kinase inhibitor 1

Tie2 kinase inhibitor 1

T6335-10mg 10mg Ask for price
Description: Tie2 kinase inhibitor 1

Tie2 kinase inhibitor 1

T6335-1g 1g Ask for price
Description: Tie2 kinase inhibitor 1

Tie2 kinase inhibitor 1

T6335-1mg 1mg Ask for price
Description: Tie2 kinase inhibitor 1

Tie2 kinase inhibitor 1

T6335-50mg 50mg Ask for price
Description: Tie2 kinase inhibitor 1

Tie2 kinase inhibitor 1

T6335-5mg 5mg Ask for price
Description: Tie2 kinase inhibitor 1

EGFR kinase inhibitor 1

T63648-10mg 10mg Ask for price
Description: EGFR kinase inhibitor 1

EGFR kinase inhibitor 1

T63648-1g 1g Ask for price
Description: EGFR kinase inhibitor 1

EGFR kinase inhibitor 1

T63648-1mg 1mg Ask for price
Description: EGFR kinase inhibitor 1

EGFR kinase inhibitor 1

T63648-50mg 50mg Ask for price
Description: EGFR kinase inhibitor 1

EGFR kinase inhibitor 1

T63648-5mg 5mg Ask for price
Description: EGFR kinase inhibitor 1

RIP1 kinase inhibitor 1

MBS3844604-10mg 10mg
EUR 1905

RIP1 kinase inhibitor 1

MBS3844604-1mg 1mg
EUR 430

RIP1 kinase inhibitor 1

MBS3844604-5mg 5mg
EUR 1165

RIP1 kinase inhibitor 1

MBS3844604-5x10mg 5x10mg
EUR 8565

RIP2 kinase inhibitor 1

MBS3841571-10mg 10mg
EUR 615

RIP2 kinase inhibitor 1

MBS3841571-50mg 50mg
EUR 1675

RIP2 kinase inhibitor 1

MBS3841571-5mg 5mg
EUR 430

RIP2 kinase inhibitor 1

MBS3841571-5x50mg 5x50mg
EUR 7520

Tpl2 Kinase Inhibitor 1

MBS5755649-25mg 25mg
EUR 1610

Tpl2 Kinase Inhibitor 1

MBS5755649-5x25mg 5x25mg
EUR 7095

RIP1 kinase inhibitor 1

MBS5767491-100mg 100mg
EUR 3280

RIP1 kinase inhibitor 1

MBS5767491-50mg 50mg
EUR 2185

RIP1 kinase inhibitor 1

MBS5767491-5x100mg 5x100mg
EUR 14615

RIP2 kinase inhibitor 1

MBS5767493-5mg 5mg
EUR 915

RIP2 kinase inhibitor 1

MBS5767493-5x5mg 5x5mg
EUR 3970

RIP2 kinase inhibitor 1

HY-133014 Get quote Ask for price
Description: RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders[1].

Tie2 kinase inhibitor 1

HY-100556 10 mg
EUR 1060.62
Description: Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2].

RIP1 kinase inhibitor 1

HY-111409 10 mg
EUR 2056.31
Description: RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1].

Tpl2 Kinase Inhibitor 1

HY-12358 1 mg
EUR 1190.49
Description: Tpl2 Kinase Inhibitor 1 is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2].

EGFR kinase inhibitor 1

HY-143246 Get quote Ask for price
Description: EGFR kinase inhibitor 1 is a potent EGFR inhibitor with IC50s of 37, 1.7, >300 nM for WT, l885R/T790M, L858R/T790M/C797S, respectively. EGFR kinase inhibitor 1 induces apoptosis and cell cycle arrest at G0/G1-phase. EGFR kinase inhibitor 1 inhibits the cell motility. EGFR kinase inhibitor 1 shows antiproliferative and anti-tumor activity[1].

Pim-1 kinase inhibitor 1

T60972-10mg 10mg Ask for price
Description: Pim-1 kinase inhibitor 1

Pim-1 kinase inhibitor 1

T60972-1g 1g Ask for price
Description: Pim-1 kinase inhibitor 1

Pim-1 kinase inhibitor 1

T60972-1mg 1mg Ask for price
Description: Pim-1 kinase inhibitor 1

Pim-1 kinase inhibitor 1

T60972-50mg 50mg Ask for price
Description: Pim-1 kinase inhibitor 1

Pim-1 kinase inhibitor 1

T60972-5mg 5mg Ask for price
Description: Pim-1 kinase inhibitor 1

Pim-1 kinase inhibitor 1

HY-143295 Get quote Ask for price
Description: Pim-1 kinase inhibitor 1 is a Pim-1 kinase inhibitor with an IC50 of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer[1].

PDGFRα kinase inhibitor 1

T12396-10mg 10mg Ask for price
Description: PDGFRα kinase inhibitor 1

PDGFRα kinase inhibitor 1

T12396-1g 1g Ask for price
Description: PDGFRα kinase inhibitor 1

PDGFRα kinase inhibitor 1

T12396-1mg 1mg Ask for price
Description: PDGFRα kinase inhibitor 1

PDGFRα kinase inhibitor 1

T12396-50mg 50mg Ask for price
Description: PDGFRα kinase inhibitor 1

PDGFRα kinase inhibitor 1

T12396-5mg 5mg Ask for price
Description: PDGFRα kinase inhibitor 1

PDGFRα kinase inhibitor 1

HY-111507 10 mg
EUR 1785.74
Description: PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].

PDGFRalpha kinase inhibitor 1

MBS3844085-10mg 10mg
EUR 685

PDGFRalpha kinase inhibitor 1

MBS3844085-50mg 50mg
EUR 1915

PDGFRalpha kinase inhibitor 1

MBS3844085-5mg 5mg
EUR 425

PDGFRalpha kinase inhibitor 1

MBS3844085-5x100mg 5x100mg
EUR 16900

PDGFRalpha kinase inhibitor 1

MBS3844085-100mg 100mg
EUR 3755

PDGFRalpha kinase inhibitor 1

MBS5753656-100mg 100mg
EUR 2840

PDGFRalpha kinase inhibitor 1

MBS5753656-25mg 25mg
EUR 1170

PDGFRalpha kinase inhibitor 1

MBS5753656-50mg 50mg
EUR 1905

PDGFRalpha kinase inhibitor 1

MBS5753656-5x100mg 5x100mg
EUR 12620

Protein kinase G inhibitor-1

HY-48958 1 mg
EUR 476.2
Description: Protein kinase G inhibitor-1 (Compound 270) is a mycobacterial protein kinase G inhibitor, with an IC50 of 0.9 μM. Protein kinase G inhibitor-1 can be used for mycobacterial infection research[1].

Pim-1/2 kinase inhibitor 1

T9229-10mg 10mg Ask for price
Description: Pim-1/2 kinase inhibitor 1

Pim-1/2 kinase inhibitor 1

T9229-1g 1g Ask for price
Description: Pim-1/2 kinase inhibitor 1

Pim-1/2 kinase inhibitor 1

T9229-1mg 1mg Ask for price
Description: Pim-1/2 kinase inhibitor 1

Pim-1/2 kinase inhibitor 1

T9229-50mg 50mg Ask for price
Description: Pim-1/2 kinase inhibitor 1

Pim-1/2 kinase inhibitor 1

T9229-5mg 5mg Ask for price
Description: Pim-1/2 kinase inhibitor 1

Pim-1 kinase inhibitor 2

T62001-10mg 10mg Ask for price
Description: Pim-1 kinase inhibitor 2

Pim-1 kinase inhibitor 2

T62001-1g 1g Ask for price
Description: Pim-1 kinase inhibitor 2

Pim-1 kinase inhibitor 2

T62001-1mg 1mg Ask for price
Description: Pim-1 kinase inhibitor 2

Pim-1 kinase inhibitor 2

T62001-50mg 50mg Ask for price
Description: Pim-1 kinase inhibitor 2

Pim-1 kinase inhibitor 2

T62001-5mg 5mg Ask for price
Description: Pim-1 kinase inhibitor 2

Pim-1 kinase inhibitor 3

T61074-10mg 10mg Ask for price
Description: Pim-1 kinase inhibitor 3

Pim-1 kinase inhibitor 3

T61074-1g 1g Ask for price
Description: Pim-1 kinase inhibitor 3

Pim-1 kinase inhibitor 3

T61074-1mg 1mg Ask for price
Description: Pim-1 kinase inhibitor 3

Pim-1 kinase inhibitor 3

T61074-50mg 50mg Ask for price
Description: Pim-1 kinase inhibitor 3

Pim-1 kinase inhibitor 3

T61074-5mg 5mg Ask for price
Description: Pim-1 kinase inhibitor 3

Pim-1 kinase inhibitor 8

HY-162006 10 mg
EUR 936.16
Description: Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC50 of 14.3 nM. Pim-1 kinase inhibitor 8 has potent cytotoxicity against MCF-7 and HepG2 cells with IC50s of 0.5 and 5.27 μM, respectively. Pim-1 kinase inhibitor 8 can used in study breast cancer[1].

Pim-1 kinase inhibitor 10

HY-162059 Get quote Ask for price
Description: Pim-1 kinase inhibitor 10 (compound 13a) is a both competitive and non-competitive inhibitor of PIM-1/2 kinase. Pim-1 kinase inhibitor 10 can induce cell apoptosis and exhibits anticancer activity. Pim-1 kinase inhibitor 10 also induces caspase 3/7 activation[1].

Pim-1 kinase inhibitor 4

HY-149976 Get quote Ask for price
Description: Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC50: 17.01 nM). Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC50 of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer[1].

Pim-1 kinase inhibitor 5

HY-149995 Get quote Ask for price
Description: Pim-1 kinase inhibitor 5 (Compound 4c) is a Pim-1 kinase inhibitor (IC50: 0.61 μM). Pim-1 kinase inhibitor 5 shows cytotoxicity against cancer cells, with IC50s of 6.95-20.19 μM for HepG2, MCF-7, PC3, and HCT-116 cells[1].

Pim-1 kinase inhibitor 6

HY-149996 Get quote Ask for price
Description: Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor with IC50 value of 0.46 μM, and has significant cytotoxic effect on cancer cells[1].

Pim-1 kinase inhibitor 3

HY-150731 Get quote Ask for price
Description: Pim-1 kinase inhibitor 3 (Compound H5) is a potent Pim-1 kinase inhibitor with an IC50 of 35.13 nM[1].

Pim-1 kinase inhibitor 2

HY-147785 Get quote Ask for price
Description: Pim-1 kinase inhibitor 2 (Compound 13) is a potent inhibitor of Pim-1 kinase. Pim-1 kinase inhibitor 2 induces apoptosis. Pim-1 kinase inhibitor 2 has the potential for the research of cancer diseases[1].

Pim-1 kinase inhibitor 9

HY-163119 Get quote Ask for price
Description: Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against Pim-1 kinase with IC50 value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity[1].

Pan-RAF kinase inhibitor 1

T63386-10mg 10mg Ask for price
Description: Pan-RAF kinase inhibitor 1

Pan-RAF kinase inhibitor 1

T63386-1g 1g Ask for price
Description: Pan-RAF kinase inhibitor 1

Pan-RAF kinase inhibitor 1

T63386-1mg 1mg Ask for price
Description: Pan-RAF kinase inhibitor 1

Pan-RAF kinase inhibitor 1

T63386-50mg 50mg Ask for price
Description: Pan-RAF kinase inhibitor 1

Pan-RAF kinase inhibitor 1

T63386-5mg 5mg Ask for price
Description: Pan-RAF kinase inhibitor 1

Pan-RAF kinase inhibitor 1

HY-142452 Get quote Ask for price
Description: Pan-RAF kinase inhibitor 1 is a potent inhibitor of Pan-RAF kinase. Pan-RAF kinase inhibitor 1 regulates MAPK signaling by inhibiting RAF kinase, thereby exerting an effect on the proliferation of RAS-mutant tumor cells. Pan-RAF kinase inhibitor 1 has the potential for the research of cancer diseases (extracted from patent WO2021110141A1, compound 16B)[1].

EML4-ALK kinase inhibitor 1

T11184-10mg 10mg Ask for price
Description: EML4-ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1

T11184-1g 1g Ask for price
Description: EML4-ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1

T11184-1mg 1mg Ask for price
Description: EML4-ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1

T11184-50mg 50mg Ask for price
Description: EML4-ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1

T11184-5mg 5mg Ask for price
Description: EML4-ALK kinase inhibitor 1

Protein kinase D inhibitor 1

T61163-10mg 10mg Ask for price
Description: Protein kinase D inhibitor 1

Protein kinase D inhibitor 1

T61163-1g 1g Ask for price
Description: Protein kinase D inhibitor 1

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