Chimère  antigeen  receptor  T-cellen (CAR-T-cellen) de toekomst in immunotherapie voor auto-immuunziekten?

Doelstelling:  CAR-T-celtherapie heeft een revolutie teweeggebracht in de behandeling van oncologische ziekten en recentelijk zijn mogelijke toepassingen bij auto-immuunziekten beschreven. De beoordeling heeft tot doel de beschikbare gegevens over de behandeling met CAR-T-cellen te integreren, met de nadruk op auto-immuunziekten, om de therapeutische vooruitgang en hun mogelijke toekomstige klinische toepasbaarheid bij auto-immuniteit te bepalen.

Materialen en methoden:  Er is gezocht in PubMed met de trefwoorden “Chimeric Antigen Receptor” en “CART cell”. De relevante documenten werden geselecteerd en de informatie werd kritisch bekeken.

Resultaten:  Bij de behandeling van auto-immuunziekten zijn in preklinische modellen drie verschillende cellulaire strategieën gebruikt, waaronder chimere antigeenreceptor T-cellen, chimere auto-antilichaamreceptor T-cellen en chimere antigeenreceptor in regulerende T-lymfocyten . Alle drie soorten therapie zijn effectief geweest. De mogelijke nadelige effecten daarin, het cytokine-afgiftesyndroom, cellulaire toxiciteit en neurotoxiciteit moeten altijd in gedachten worden gehouden.

Conclusies:  Hoewel er nog geen informatie over mensen beschikbaar is, laten preklinische modellen van CAR-T-cellen bij de behandeling van auto-immuunziekten veelbelovende resultaten zien, zodat ze in de toekomst een nuttige en effectieve therapie kunnen worden bij de behandeling van deze pathologieën.

Ovalbumine  Antigen -Specifieke Activatie van menselijke T-cel  -receptor  lijkt sterk op Oplosbare Antibody Stimulatieter onthuld door BOOST fosfotyrosine Proteomics

Activering van de T-celreceptor (TCR) leidt tot een netwerk van vroege signalering, voornamelijk georkestreerd door tyrosinefosforylering in T-cellen. De TCR wordt gewoonlijk geactiveerd met behulp van oplosbare anti-TCR-antilichamen, maar deze benadering is niet antigeenspecifiek. Als alternatief wordt aangenomen dat het activeren van de TCR met behulp van specifieke antigenen met een reeks bindingsaffiniteiten in de vorm van een peptide-major histocompatibiliteitscomplex (pMHC) meer fysiologisch is. Vanwege het ontbreken van grootschalige fosfotyrosine (pTyr) proteomische onderzoeken die anti-TCR-antilichamen en pMHC rechtstreeks vergelijken, blijft een uitgebreide definitie van deze geactiveerde toestanden echter raadselachtig.

Opheldering van het tyrosinefosfoproteoom met behulp van kwantitatieve pTyr-proteomics maakt een beter begrip mogelijk van de unieke kenmerken van deze activerende middelen en de rol van ligandbindingsaffiniteit op signalering. Hier passen we de latest opgerichte breedspectrumoptimalisatie van selectieve triggering (BOOST) toe om verstoringen in tyrosinefosforylering van menselijke TCR te onderzoeken, veroorzaakt door anti-TCR-antilichamen en pMHC. Onze gegevens laten zien dat pMHC-activering met hoge affiniteit ovalbumine (OVA) van de menselijke TCR een grotendeels vergelijkbare, zij het mogelijk sterkere, pTyr-gemedieerdesignaalregulerende as vergeleken met het anti-TCR-antilichaam. De signaleringsoutput die resulteert uit OVA pMHC-varianten correleert goed met hun zwakkere affiniteiten, waardoor affiniteit-afstembare controle van de signaalsterkte mogelijk is. Gezamenlijk bieden we een raamwerk voor het toepassen van BOOST om pTyr-gemedieerde signaalroutes van menselijke T-cellen te vergelijken die op een antigeenonafhankelijke en antigeenspecifieke manier zijn geactiveerd.

HIV-1 p24 ELISA Kit
Z7040001	Biochain	1 kit	EUR 974.4
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

HIV-1 p24
E5-00024	EnoGene	1mg	EUR 1152

HIV-1 p24
E62H002	EnoGene	100ug	EUR 458.4

HIV Type 1 p24 Antigen ELISA (96 Determinations)
0801111	Zeptometrix	96T	EUR 657.79
Description: Please contact Gentaur in order to receive the datasheet of the product.

HIV Type 1 p24 Antigen ELISA (96 Determinations)
801111	Zeptometrix	96 Determinations	EUR 591

HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations)
801002	Zeptometrix	96 Determinations	EUR 574

HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations)
0801002	Zeptometrix	96T	EUR 603

HIV type 1 P24
DAG1520	Creative Diagnostics	100 µg	EUR 972

HIV-1 p24 Antibody
7313-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains.

HIV-1 p24 Antibody
7313-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains.

Recombinant HIV-1 p24
7-07603	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 p24
7-07604	CHI Scientific	500µg	Ask for price

Recombinant HIV-1 p24
7-07605	CHI Scientific	1000µg	Ask for price

HIV-1 Gag p24
05-005	Sceti	50 ug	EUR 434.4
Description: The HIV-1 Gag p24 is available in Europe and for worldwide shipping via Gentaur.

HIV-1 Gag p24
05-006	Sceti	250 ug	EUR 1154.4
Description: The HIV-1 Gag p24 is available in Europe and for worldwide shipping via Gentaur.

HIV-1, p24 Protein
abx069857-1mg	Abbexa	1 mg	EUR 1888.8

HIV-1 p24 Protein
abx169032-1mg	Abbexa	1 mg	EUR 661.2

HIV-1 p24 Antibody
20-abx137062	Abbexa	EUR 427.20 EUR 627.60	0.5 mg 1 mg

HIV-1 p24 Antibody
abx021869-1mg	Abbexa	1 mg	EUR 794.4

HIV-1 p24 Antibody
abx021870-1mg	Abbexa	1 mg	EUR 760.8

HIV-1 p24 Antibody
abx021871-1mg	Abbexa	1 mg	EUR 794.4

HIV-1 p24 Antibody
abx021872-1mg	Abbexa	1 mg	EUR 794.4

HIV-1 p24 Antibody
abx021873-1mg	Abbexa	1 mg	EUR 794.4

HIV-1 p24 Antibody
abx021882-1mg	Abbexa	1 mg	EUR 1178.4

HIV-1 p24 Antibody
abx021883-1mg	Abbexa	1 mg	EUR 1220.4

HIV-1 p24 Antibody
abx021886-1mg	Abbexa	1 mg	EUR 1220.4

HIV-1 p24 Antibody
abx021887-1mg	Abbexa	1 mg	EUR 1220.4

HIV-1 p24 Antibody
abx021888-1mg	Abbexa	1 mg	EUR 1220.4

HIV-1 p24 Antibody
abx023027-1ml	Abbexa	1 ml	EUR 693.6

HIV 1 p24 Protein
abx060589-1mg	Abbexa	1 mg	EUR 1545.6

HIV-1 p24 Protein
abx061424-05mg	Abbexa	0.5 mg	EUR 886.8

HIV-1 p24 Antibody
abx023925-1mg	Abbexa	1 mg	EUR 828

HIV-1 p24 Antibody
abx023926-1mg	Abbexa	1 mg	EUR 828

HIV-1 p24 Protein
20-abx261886	Abbexa	EUR 5388.00 EUR 393.60 EUR 276.00	1 mg 20 ug 5 ug

p24-HIV(p24/661) Antibody
BNCA0661-250	Biotium	250uL	EUR 459.6
Description: Primary antibody against p24-HIV(p24/661), APC conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNCAP0661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNCAP0661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC610661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF660R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC610661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF660R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNCR0661-250	Biotium	250uL	EUR 459.6
Description: Primary antibody against p24-HIV(p24/661), RPE conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNUB0661-100	Biotium	100uL	EUR 250.8
Description: Primary antibody against p24-HIV(p24/661), Concentration: 0.2mg/mL

p24-HIV(p24/661) Antibody
BNUB0661-500	Biotium	500uL	EUR 549.6
Description: Primary antibody against p24-HIV(p24/661), Concentration: 0.2mg/mL

p24-HIV(p24/661) Antibody
BNC430661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF543 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC430661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF543 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC400661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC400661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC880661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC880661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC810661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC810661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNCH0661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNCH0661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNCP0661-250	Biotium	250uL	EUR 459.6
Description: Primary antibody against p24-HIV(p24/661), PerCP conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNUM0661-50	Biotium	50uL	EUR 474
Description: Primary antibody against p24-HIV(p24/661), 1mg/mL

p24-HIV(p24/661) Antibody
BNC050661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC050661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC680661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF568 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC680661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF568 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC700661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC700661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC800661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC800661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNCB0661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), Biotin conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNCB0661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), Biotin conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC940661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC940661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC550661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF555 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC550661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF555 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC470661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF647 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC470661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF647 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC040661-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody
BNC040661-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL

HIV p24 Antibody
abx021867-1mg	Abbexa	1 mg	EUR 1612.8

HIV p24 Antibody
abx021868-1mg	Abbexa	1 mg	EUR 1612.8

Human(HIV-P24)
QY-E05679	Qayee Biotechnology	96T	EUR 433.2

HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations)
801200	Zeptometrix	5 X 96 Determinations	EUR 2330

HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations)
0801200	Zeptometrix	5 X 96T	EUR 2543.52
Description: Please contact Gentaur in order to receive the datasheet of the product.

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed
ELISA-1	Alpha Diagnostics	1	EUR 242.4

HIV type 1 P24 [His]
DAG2375	Creative Diagnostics	100 µg	EUR 868.8

HIV type 1 P24 [His]
DAG2377	Creative Diagnostics	100 µg	EUR 868.8

HIV type 1 p24 [FITC]
DAGH004	Creative Diagnostics	50 Tests	EUR 1112.4

HIV type 1 P24 [GST]
DAG1516	Creative Diagnostics	100 µg	EUR 774

HIV type 1 P24 [His]
DAG1518	Creative Diagnostics	100 µg	EUR 774

HIV type 1 P24 [Biotin]
DAG1519	Creative Diagnostics	100 µg	EUR 972

HIV type 1 P24 [His]
DAG1799	Creative Diagnostics	50 ug	EUR 2017.2

HIV-1 p24 Recombinant Protein
53-341	ProSci	0.01 mg	EUR 789.9
Description: HIV-1 p24 Recombinant Protein

Recombinant HIV-1 p24 Core
7-07597	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 p24 Core
7-07598	CHI Scientific	500µg	Ask for price

Recombinant HIV-1 p24 Core
7-07599	CHI Scientific	1000µg	Ask for price

Recombinant HIV-1 p24 , 24kDa
7-07621	CHI Scientific	2µg	Ask for price

Recombinant HIV-1 p24 , 24kDa
7-07622	CHI Scientific	10µg	Ask for price

Recombinant HIV-1 p24 , 24kDa
7-07623	CHI Scientific	100µg	Ask for price

HIV 1 / 2 p24 Antibody
abx021866-1mg	Abbexa	1 mg	EUR 1212

HIV-1 p24 Antibody (FITC)
abx021884-100ug	Abbexa	100 ug	EUR 886.8

HIV 1 / 2 p24 Antibody
abx021890-1mg	Abbexa	1 mg	EUR 1212

HIV-1 p24 Antibody (FITC)
abx023026-1ml	Abbexa	1 ml	EUR 678

HIV-1 p24 Antibody (Biotin)
abx023028-1ml	Abbexa	1 ml	EUR 794.4

HIV-1 p24 Antibody (HRP)
abx023029-1ml	Abbexa	1 ml	EUR 886.8

HIV-1 p24 Core Protein
20-abx260141	Abbexa	EUR 1062.00 EUR 410.40 EUR 1646.40	0.5 mg 100 ug 1 mg

Polyclonal HIV-1 p24 Antibody
APR11116G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIV-1 p24 . This antibody is tested and proven to work in the following applications:

HIV-1 p24, His tag
E410A26-20	EnoGene	20μg	EUR 520.8

HIV-1 p24 Antibody [8G9]
PM-6335-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9]
PM-6335-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4]
PM-6585-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4]
PM-6585-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

Anti-HIV-1 p24 Antibody
STJ60071	St John's Laboratory	100 µg	EUR 508.8

Anti-HIV-1 p24 Antibody
STJ60072	St John's Laboratory	100 µg	EUR 508.8

HIV Type-1 p24 Antibody
V2344-100UG	NSJ Bioreagents	100 ug	EUR 499
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody
V2344-20UG	NSJ Bioreagents	20 ug	EUR 219
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody
V2344CF488-100T	NSJ Bioreagents	100 Tests	EUR 499
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody
V2344SAF-100UG	NSJ Bioreagents	100 ug	EUR 499
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

Human HIV(1+2 antibodies plus p24 antigen (4th Generation) ELISA Kit
EH4101	FN Test	96T	EUR 571.5
Description: Method of detection: Qualitative ;Reacts with: Homo sapiens;Sensitivity: Qualitative

HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations)
0801008	Zeptometrix	5 X 96T	EUR 2543.52
Description: Please contact Gentaur in order to receive the datasheet of the product.

HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations)
801008	Zeptometrix	5 X 96 Determinations	EUR 2386

HIV-1 p24 Immune Complex Dissociation Kit
Z7040009	Biochain	1 kit	EUR 207.6
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Anti-HIV p24 antibody
10-2842	Fitzgerald	1 mg	EUR 360
Description: Anti-HIV p24 Ag monoclonal antibody

Anti-HIV p24 antibody
10-2843	Fitzgerald	1 mg	EUR 360
Description: Anti-HIV p24 Ag monoclonal antibody

Anti-HIV p24 antibody
10-2844	Fitzgerald	1 mg	EUR 360
Description: Anti-HIV p24 Ag monoclonal antibody

Anti-HIV p24 antibody
10-2845	Fitzgerald	1 mg	EUR 360
Description: Anti-HIV p24 Ag monoclonal antibody

QuickTiter HIV Lentivirus Quantitation Kit (p24 ELISA)
VPK-108-H	Cell Biolabs	96 assays	EUR 866.4
Description: Quantitation of the HIV-1 p24 core protein of a lentiviral vector is an efficient, well-published method for determining lentivirus physical titer. The QuickTiter Lentivirus Quantitation Kits provide a convenient method of p24 antigen quantitation.

QuickTiter HIV Lentivirus Quantitation Kit (p24 ELISA)
VPK-108-H-5	Cell Biolabs	5 x 96 assays	EUR 3560.4
Description: Quantitation of the HIV-1 p24 core protein of a lentiviral vector is an efficient, well-published method for determining lentivirus physical titer. The QuickTiter Lentivirus Quantitation Kits provide a convenient method of p24 antigen quantitation.

HIV type 1 P24 (HXBc2) [His]
DAG2376	Creative Diagnostics	100 µg	EUR 868.8

HIV type 1 P24 (p24HXBc2) [His]
DAG2378	Creative Diagnostics	100 µg	EUR 1095.6

HIV type 1 P24 (CN54) [His]
DAG2380	Creative Diagnostics	100 µg	EUR 1095.6

Recombinant HIV-1 p24 Core, Sf9
7-07600	CHI Scientific	2µg	Ask for price

Recombinant HIV-1 p24 Core, Sf9
7-07601	CHI Scientific	10µg	Ask for price

Recombinant HIV-1 p24 Core, Sf9
7-07602	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 p24 His Tag
7-07606	CHI Scientific	5µg	Ask for price

Recombinant HIV-1 p24 His Tag
7-07607	CHI Scientific	20µg	Ask for price

Recombinant HIV-1 p24 His Tag
7-07608	CHI Scientific	1mg	Ask for price

Recombinant HIV-1 p24, Biotin Labeled
7-07612	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 p24, Biotin Labeled
7-07613	CHI Scientific	500µg	Ask for price

Recombinant HIV-1 p24, Biotin Labeled
7-07614	CHI Scientific	1000µg	Ask for price

Recombinant HIV-1 gag p17, p24
7-07675	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 gag p17, p24
7-07676	CHI Scientific	500µg	Ask for price

Recombinant HIV-1 gag p17, p24
7-07677	CHI Scientific	1000µg	Ask for price

Mouse antibody for HIV-1 p24
1941	Virostat	100 ug	EUR 399.3
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA.

Mouse antibody for HIV-1 p24
1946	Virostat	100 ug	EUR 425.4
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA.

Mouse antibody for HIV-1 p24
1947	Virostat	100 ug	EUR 425.4
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA.

Mouse antibody for HIV-1 p24
1948	Virostat	100 ug	EUR 425.4
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA.

Mouse antibody for HIV-1 p24
1949	Virostat	100 ug	EUR 425.4
Description: This is purified Mouse monoclonal antibody against HIV-1 p24 for WB, ELISA.

HIV-1 gag p24 IIIB Protein
abx060586-05mg	Abbexa	0.5 mg	EUR 1128

HIV-1 p24 Core, Sf9 Protein
20-abx260012	Abbexa	EUR 2815.20 EUR 493.20 EUR 276.00	100 ug 10 ug 2 µg

HIV-1 gag p17, p24 Protein
20-abx260277	Abbexa	EUR 1062.00 EUR 410.40 EUR 1930.80	0.5 mg 100 ug 1 mg

HIV-1 p24, Biotin Labeled Protein
20-abx260358	Abbexa	EUR 1496.40 EUR 560.40 EUR 2364.00	0.5 mg 100 ug 1 mg

HIV-1 p24, 24 kDa Protein
20-abx263118	Abbexa	EUR 1562.40 EUR 393.60 EUR 276.00	100 ug 10 ug 2 µg

Polyclonal HIV-1 p24 Antibody [7F4]
APR11117G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Mouse that recognizes and binds to Human HIV-1 p24 [7F4] . This antibody is tested and proven to work in the following applications:

HIV-1 p24 Antibody [8G9] (biotin)
PM-6335-biotin-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9] (biotin)
PM-6335-biotin-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9] (HRP)
PM-6335-HRP-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9] (HRP)
PM-6335-HRP-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (biotin)
PM-6585-biotin-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (biotin)
PM-6585-biotin-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (HRP)
PM-6585-HRP-002mg	ProSci	0.02 mg	EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (HRP)
PM-6585-HRP-01mg	ProSci	0.1 mg	EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

Recombinant HIV-1 p24 Protein [His]
VAng-0527Lsx-inquire	Creative Biolabs	inquire	Ask for price
Description: HIV type 1 P24 Antigen, recombinant protein from insect cell expression system.

Recombinant HIV-1 P24 Protein (Gorillas)
VAng-Lsx0245-1mg	Creative Biolabs	1 mg	EUR 3058.8
Description: HIV type 1 P24 (Antigen), recombinant protein from E. coli.

Monoclonal Mouse Anti-Hiv（P24）
C010105-10mg	Unibiotest	10mg	EUR 1641.6

Monoclonal Mouse Anti-Hiv（P24）
C010105-1mg	Unibiotest	1mg	EUR 322.8

Recombinant HIV-I p24 gag
7-07618	CHI Scientific	100µg	Ask for price

Recombinant HIV-I p24 gag
7-07619	CHI Scientific	500µg	Ask for price

Recombinant HIV-I p24 gag
7-07620	CHI Scientific	1000µg	Ask for price

anti-HIV p24 Monoclonal antibody
012-A-01mg	Virogen	0,1 mg	EUR 321
Description: anti-HIV-1 p24 IgG1 (monoclonal) Produced against a recombinant protein.

anti-HIV p24 Monoclonal antibody
012-A-1000ug	Virogen	1000 ug	EUR 1539
Description: anti-HIV-1 p24 IgG1 (monoclonal) Produced against a recombinant protein.

HIV-I p24 gag Protein
20-abx260279	Abbexa	EUR 1062.00 EUR 410.40 EUR 1930.80	0.5 mg 100 ug 1 mg

Anti-HIV p24 protein antibody
STJ16100518	St John's Laboratory	100 µg	EUR 487.2

Anti-HIV/p24 monoclonal Antibody
A1020-100	Biovision	each	EUR 444

Goat Anti-HIV-1 p24 Polyclonal Antibody
DPAB0249	Creative Diagnostics	1 ml	EUR 781.2

Goat Anti-HIV-1 p24 Polyclonal Antibody
DPAB0250	Creative Diagnostics	1 ml	EUR 826.8

Goat Anti-HIV-1 p24 Polyclonal Antibody
DPAB0251	Creative Diagnostics	1 ml	EUR 1146

HIV-1 gag Protein p24 (137-154)
5-01316	CHI Scientific	4 x 1mg	Ask for price

HIV-1 gag Protein p24 (194-210)
5-01317	CHI Scientific	4 x 1mg	Ask for price

Recombinant HIV-1 p24 gag, His Tag
7-07609	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 p24 gag, His Tag
7-07610	CHI Scientific	500µg	Ask for price

Recombinant HIV-1 p24 gag, His Tag
7-07611	CHI Scientific	1000µg	Ask for price

Recombinant HIV-1 p24, Horseradish Peroxidase Labeled
7-07615	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 p24, Horseradish Peroxidase Labeled
7-07616	CHI Scientific	500µg	Ask for price

Recombinant HIV-1 p24, Horseradish Peroxidase Labeled
7-07617	CHI Scientific	1000µg	Ask for price

Recombinant HIV-1 gag p17, p24, gp120
7-07678	CHI Scientific	100µg	Ask for price

Recombinant HIV-1 gag p17, p24, gp120
7-07679	CHI Scientific	500µg	Ask for price

Recombinant HIV-1 gag p17, p24, gp120
7-07680	CHI Scientific	1000µg	Ask for price

Anti-Capsid protein p24 (HIV-1) Purified
11-327-C025	ExBio	0.025 mg	EUR 135.6

Anti-Capsid protein p24 (HIV-1) Purified
11-327-C100	ExBio	0.1 mg	EUR 223.2

Mouse Monoclonal Anti- HIV-1 p24 IgG
AB-15210	Alpha Diagnostics	100 ug	EUR 416.4

HIV-1 gag p17, p24, gp120 Protein
20-abx260274	Abbexa	EUR 1062.00 EUR 410.40 EUR 1930.80	0.5 mg 100 ug 1 mg

HIV-1 p24, Horseradish Peroxidase Labeled Protein
20-abx260359	Abbexa	EUR 1496.40 EUR 560.40 EUR 2364.00	0.5 mg 100 ug 1 mg

HIV-1 gag Protein p24 (194-210)
H-2986.0500	Bachem	0.5mg	EUR 327.6
Description: Sum Formula: C73H126N20O23S; CAS# [141281-67-6]

HIV-1 gag Protein p24 (194-210)
H-2986.1000	Bachem	1.0mg	EUR 559.2
Description: Sum Formula: C73H126N20O23S; CAS# [141281-67-6]

HIV-1 gag Protein p24 (137-154)
H-3006.0500	Bachem	0.5mg	EUR 327.6
Description: Sum Formula: C92H158N26O26S; CAS# [198636-98-5]

HIV-1 gag Protein p24 (137-154)
H-3006.1000	Bachem	1.0mg	EUR 559.2
Description: Sum Formula: C92H158N26O26S; CAS# [198636-98-5]

Bilaterale anterior cerebrale slagader occlusie na CD19- en BCMA-gerichte chimere  antigeen  receptor  van T-celtherapie voor een patiënt myeloom

Chimere antigeenreceptor T (CAR-T)-celtherapie is een veelbelovende behandeling voor recidiverend/refractair multipel myeloom (RRMM). In ons vorige rapport was CD19- en BCMA-gerichte gelijktijdige toediening van CAR-T geassocieerd met een hoog responspercentage. Hoewel cytokine launch syndrome (CRS) en neurotoxiciteit frequente complicaties zijn na behandeling met CAR-T, wordt een herseninfarct zelden gerapporteerd als een CAR-T-gerelateerde complicatie. We rapporteerden een 73-jarige vrouwelijke MM-patiënt die CD19- en BCMA-gerichte CAR-T ontving voor refractaire ziekte.

Haar ziekte reageerde op CAR-T- therapie, maar ze ontwikkelde neurologische symptomen na CRS. Craniale CT en MRI toonden meerdere herseninfarcten en bilaterale anterieure cerebrale arterie (ACA) occlusie aan. We suggereren dat een ander herseninfarct dan CAR-T-gerelateerde neurotoxiciteit de onderliggende oorzaak is van abnormale neuropsychologische symptomen, en diagnostische beeldvormingstests moeten actief worden uitgevoerd om ischemische cerebrovasculaire gebeurtenissen uit te sluiten.

Het intracellulaire domein van CD40 is een krachtige Costimulatoire Ingredient in chimère  Antigen  Receptoren

De co-stimulerende domeinen die zijn ingebouwd in chimere antigeenreceptoren (CAR’s) van de tweede generatie en de derde generatie, hebben een sterke invloed op de functie van CAR-T-cellen . Hier hebben we CAR’s van de tweede generatie en de derde generatie onderzocht die het signaleringsdomein van de CD40-receptor herbergen als een nieuw costimulerend component in vergelijking met vergelijkbare CAR’s die het 4-1BB-domein dragen . In CAR’s van beide generaties was CD40 krachtiger dan 4-1BB bij het triggeren van de NF-KB-signaleringsroute.

In humane T-cellen van 2 donoren was CD40 vergelijkbaar met 4-1BB bij het opreguleren van co-stimulerende en activatiemarkers, het induceren van pro-inflammatoire cytokinesecretie en het mediëren van het doden van doelwitcellen. Interessant genoeg waren er duidelijk verschillen in het responspatroon van T-cellen van de 2 donoren met betrekking tot CD40 en 4-1BB. We concluderen dat in menselijke T-cellen het CD40- signaleringsdomein een krachtig co-stimulerend component is in CAR’s van zowel de tweede generatie als de derde generatie.

Een systematische herziening van de rol van chimere  Antigeen  Receptor  T (CAR-T) celtherapie bij de behandeling van solide tumoren

Chimere antigeenreceptor T (CAR-T) celtherapie maakt gebruik van de eigen T-lymfocyten van de patiënt die zijn ontworpen om kankercellen aan te vallen. Het is door de Meals and Drug Administration (FDA) goedgekeurd voor verschillende hematologische maligniteiten en wordt momenteel geëvalueerd bij solide kankers in vroege fase-onderzoeken. We deden een systematische evaluate bestaande uit 15 prospectieve klinische onderzoeken (n = 159) die CAR-T-cellen in solide kankers evalueerden . Vroege fase-onderzoeken toonden veelbelovende responspercentages bij ovariumepitheelkanker (100%), humaan epidermale groeifactorreceptor 2  (HER2)-positief sarcoom (67%) , epidermale groeifactorreceptor (EGFR)-positieve galwegkanker (65%), gevorderde maag-/pancreaskanker (82%), hepatocellulair carcinoom (67%),en colorectale kanker (70%) .

De mediane algehele respons voor alle maligniteiten was 62% (bereik 17%-100%) . De mediane progressievrije overleving en de totale overleving werden in de meeste onderzoeken niet bereikt. Cytokine-afgiftesyndroom werd gezien bij slechts één patiënt met cholangiocarcinoom die EGFR-specifieke CAR-T-celtherapie kreeg. Hoewel de overlevingsgegevens nog steeds niet volgroeid zijn, liet CAR-T-celtherapie bij solide maligniteiten bemoedigende responspercentages zien en werd goed verdragen.

Verschillen in lymfoompatiënten tussen chimeer  antigeen  receptor  van T-cel therapeutische proeven en bevolking

Chimere antigeenreceptor (CAR)-T-celtherapieën lijken veelbelovende behandelingen te zijn voor non-Hodgkin- en B-cellymfoom. Verschillende CAR-T-therapieën die zijn goedgekeurd door de Amerikaanse Meals and Drug Administration, zijn echter alleen op werkzaamheid getest in relatief weinig klinische onderzoeken met een enkele arm met kleine steekproefomvang. We probeerden de verschillen tussen patiënten in deze onderzoeken en de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom te onderzoeken. Vijfhonderdtweeëntwintig patiënten uit 15 CAR-T-onderzoeken gevonden in een systematische evaluate en 417.492 patiënten uit de Surveillance, Epidemiology, and Finish Outcomes (SEER) Program-database werden vergeleken.

De deelnemers aan de CAR-T-studie leken jonger (46,7% jonger dan 70 jaar vs. 42,2%) , meer mannelijk (68,0% vs. 55,7%) en werden gedurende een kortere periode gevolgd in vergelijking met patiënten in de SEER-populatie (gemiddelde [M] 45,6 maanden, 95% betrouwbaarheidsinterval [BI] 17,7 tot 63,three maanden follow-up vs. M 57,1 maanden, 95% BI 57,Zero tot 57,three maanden overleving). Deelnemers aan de CAR-T-studie kunnen aanzienlijk verschillen van de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom . De effectiviteit van CAR-T-therapieën bij de algemene populatie van lymfoompatiënten kan verschillen van de effectiviteit die is aangetoond in onderzoeken. Nieuw gecreëerde CAR-T-patiëntenregisters zijn essentieel om de effectiviteit van de therapieën op populatieniveau huge te stellen.

 

Adenosine Kinase Inhibitor (hydrate)
C5282-1	ApexBio	1 mg	EUR 134.4
Description: IC50: 1.7 nM in cell-free assaysAdenosine Kinase Inhibitor is an inhibitor of adenosine kinase. Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations.

DiscoveryProbe? Kinase Inhibitor Library
L1024-.1	ApexBio	100 uL/well(10 mM solution)	EUR 7520.4

IKK-? Kinase Inhibitor II
1811-1	Biovision	each	EUR 189.6

VEGFR Tyrosine Kinase Inhibitor II
C4603-1	ApexBio	1 mg	EUR 141.6

DiscoveryProbe? Tyrosine Kinase Inhibitor Library
L1028-.1	ApexBio	100 uL/well(10 mM solution)	EUR 6476.4

Kinase inhibitor-1
HY-43533	MedChemExpress	5mg	EUR 680.4

ET-1/ Rat ET- 1 ELISA Kit
ELA-E0482r	Lifescience Market	96 Tests	EUR 1063.2

HPGDS inhibitor 1
B1046-1	ApexBio	1 mg	EUR 217.2
Description: HPGDS inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS) with IC50 value of 0.7nM [1].Prostaglandin D2 (PGD2) is a mediator of allergy and inflammation.

TAO Kinase inhibitor 1
HY-112136	MedChemExpress	50mg	EUR 955.2

MAPKII Kinase Inhibitor (Hsp25 Kinase Inhibitor)
SIH-120A	Stressmarq	1 mg	EUR 214.8
Description: The substance MAPKII Kinase Inhibitor is a hsp25 kinase inhibitor. It is synthetically produced and has a purity of >95%. The pure substance is white solid which is soluble in DMSO or H20.

ET-1 Polyclonal Antibody
41562-100ul	SAB	100ul	EUR 302.4

ET-1 Polyclonal Antibody
41562-50ul	SAB	50ul	EUR 224.4

ET-1 Polyclonal Antibody
ABP52878-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of ET-1 from Human. This ET-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ET-1

ET-1 Polyclonal Antibody
ABP52878-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of ET-1 from Human. This ET-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ET-1

ET-1 Polyclonal Antibody
ABP52878-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of ET-1 from Human. This ET-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ET-1

ET-1 Polyclonal Antibody
ES3877-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against ET-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

ET-1 Polyclonal Antibody
ES3877-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against ET-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Anti-ET-1 antibody
STJ96512	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to ET-1.

Rabbit Endothelin 1, ET-1 ELISA Kit
1-CSB-E06951Rb	Cusabio	EUR 1160.40 EUR 7110.00 EUR 3760.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rabbit Endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

rat Endothelin 1, ET-1 ELISA Kit
1-CSB-E06979r	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring rat Endothelin 1, ET-1 in samples from serum, plasma, cell lysates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Dog Endothelin 1, ET-1 ELISA Kit
1-CSB-E07002c	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Dog Endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Endothelin 1, ET-1 ELISA Kit
1-CSB-E07007h	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Endothelin 1, ET-1 in samples from serum, cell culture supernates, urine, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Endothelin 1, ET-1 ELISA Kit
1-CSB-E05145m	Cusabio	EUR 1135.20 EUR 6938.40 EUR 3672.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Endothelin 1, ET-1 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Pig endothelin 1, ET-1 ELISA Kit
1-CSB-E06806p	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Pig endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Cyclin-dependent kinase inhibitor 1 (CDKN1A)
1-CSB-EP005086HU	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Cyclin-dependent kinase inhibitor 1(CDKN1A) expressed in E.coli

Endothelin 1 (ET-1) Antibody
abx024086-100ug	Abbexa	100 ug	EUR 1128

Sorafenib (Raf-1 kinase inhibitor)
SIH-476-10MG	Stressmarq	10 mg	EUR 145.2
Description: The substance Sorafenib is a raf-1 kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is off white powder which is soluble inDMSO (200mg/ml) or ethanol (3mg/ml).

Sorafenib (Raf-1 kinase inhibitor)
SIH-476-50MG	Stressmarq	50 mg	EUR 346.8
Description: The substance Sorafenib is a raf-1 kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is off white powder which is soluble inDMSO (200mg/ml) or ethanol (3mg/ml).

p16-INK4a Cyclin-Dependent Kinase Inhibitor 2A Human Recombinant Protein
PROTP42771-1	BosterBio	Regular: 20ug	EUR 380.4
Description: CDKN2A Human Recombinant produced in E.Coli, it's a single non-glycosylated polypeptide chain containing 156 amino acids, approximately 16.5 kDa.;CDKN2A is purified by proprietary chromatographic techniques.

187-1, N-WASP inhibitor
B5251-1	ApexBio	1 mg	EUR 478.8

AKT Kinase Inhibitor
A3150-10	ApexBio	10 mg	EUR 1363.2
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor
A3150-5	ApexBio	5 mg	EUR 819.6
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor
A3150-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 895.2
Description: AKT Kinase Inhibitor

MAPKII Kinase Inhibitor
abx076811-1mg	Abbexa	1 mg	EUR 376.8

Tie2 kinase inhibitor
A5979-100	ApexBio	100 mg	EUR 1452
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor
A5979-25	ApexBio	25 mg	EUR 477.6
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor
A5979-5	ApexBio	5 mg	EUR 199.2
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor
A5979-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 536.4
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor
E1KS1577	EnoGene	10mg	EUR 1849.2

AKT Kinase Inhibitor
HY-10249A	MedChemExpress	10mg	EUR 1052.4

Tyrosine kinase inhibitor
HY-10421	MedChemExpress	25mg	EUR 459.6

Dasatinib (Kinase inhibitor)
SIH-440-25MG	Stressmarq	25 mg	EUR 238.8
Description: The substance Dasatinib is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ).

Dasatinib (Kinase inhibitor)
SIH-440-5MG	Stressmarq	5 mg	EUR 160.8
Description: The substance Dasatinib is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ).

K252A (Kinase inhibitor)
SIH-455-100UG	Stressmarq	100 µg	EUR 157.2
Description: The substance K252A is a kinase inhibitor. It is nonomuraea longicatena and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in DMSO.

K252A (Kinase inhibitor)
SIH-455-1MG	Stressmarq	1 mg	EUR 358.8
Description: The substance K252A is a kinase inhibitor. It is nonomuraea longicatena and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in DMSO.

K252B (Kinase inhibitor)
SIH-456-100UG	Stressmarq	100 µg	EUR 218.4
Description: The substance K252B is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml).

K252B (Kinase inhibitor)
SIH-456-1MG	Stressmarq	1 mg	EUR 682.8
Description: The substance K252B is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml).

Midostaurin (Kinase inhibitor)
SIH-468-1MG	Stressmarq	1 mg	EUR 205.2
Description: The substance Midostaurin is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white powder which is soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml).

Midostaurin (Kinase inhibitor)
SIH-468-5MG	Stressmarq	5 mg	EUR 608.4
Description: The substance Midostaurin is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white powder which is soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml).

Tie2 Kinase Inhibitor
B1338-25	Biovision	each	EUR 907.2

Tie2 Kinase Inhibitor
B1338-5	Biovision	each	EUR 314.4

YAP-TEAD Inhibitor 1 (Peptide 17)
A1149-1	ApexBio	1 mg	EUR 282

ET-1 Polyclonal Conjugated Antibody
C41562	SAB	100ul	EUR 476.4

Porcine ET-1 ELISA Kit
EPE0184	Abclonal	96Tests	EUR 625.2

Rabbit ET-1 ELISA Kit
ERTE0184	Abclonal	96Tests	EUR 625.2

Rat ET-1 ELISA Kit
ERE0184	Abclonal	96Tests	EUR 625.2

Mouse ET-1 ELISA Kit
EME0184	Abclonal	96Tests	EUR 625.2

Human ET-1 ELISA Kit
EHE0184	Abclonal	96Tests	EUR 625.2

Goat ET-1 ELISA Kit
EGTE0184	Abclonal	96Tests	EUR 625.2

Bovine ET-1 ELISA Kit
EBE0184	Abclonal	96Tests	EUR 625.2

Canine ET-1 ELISA Kit
ECE0184	Abclonal	96Tests	EUR 625.2

Anserini ET-1 ELISA Kit
EAE0184	Abclonal	96Tests	EUR 625.2

Canine ET-1 ELISA Kit
ELA-E0482d	Lifescience Market	96 Tests	EUR 1113.6

Big ET/ Rat Big ET ELISA Kit
ELA-E0483r	Lifescience Market	96 Tests	EUR 1063.2

ET-1(Endothelin-1) ELISA Kit
EU0205	FN Test	96T	EUR 628.92
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: General;Sensitivity: 0.625pg/ml

p21/Cyclin-Dependent Kinase Inhibitor 1
MO47036	Neuromics	100 ul	EUR 418.8

NFAT Inhibitor
A4539-1	ApexBio	1 mg	EUR 165.6
Description: Selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

Lck Inhibitor
A3539-1	ApexBio	1 mg	EUR 184.8
Description: Lck Inhibitor is a small-molecule inhibitor of with IC50 value of 7 nM [1].The lymphocyte specific kinase which expressed in NK cells and T-cells is a member of the Src kinase family.

EGFR Inhibitor
C3327-1	ApexBio	1 mg	EUR 184.8
Description: EGFR inhibitor is a cell permeable, pyrimidine compound that selectively inhibits the EGFR kinase with IC50 value of 21 nM [1]. EGFR is a transmembrane protein, and is a receptor for members of epidermal growth factor family.

Stat5 Inhibitor
9484-1	Biovision	each	EUR 144

Chk2 Inhibitor
1702-1	Biovision	each	EUR 216

SCD1 Inhibitor
1716-1	Biovision	each	EUR 261.6

ACC2 Inhibitor
1717-1	Biovision	each	EUR 261.6

Syk Inhibitor
1983-1	Biovision	each	EUR 151.2

Apoptosis Inhibitor
27734-1	BPS Bioscience	10 mg	EUR 150
Description: Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction. It does not directly inhibit caspase-3, but its effects are attributable to the inhibition of caspase-3 activation.

Phosphatase Inhibitor Cocktail 1 (100X in DMSO)
K1012-1	ApexBio	1 ml	EUR 122.4

Human Cyclin-dependent kinase inhibitor 1(CDKN1A) ELISA kit
1-CSB-EL005086HU	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Cyclin-dependent kinase inhibitor 1(CDKN1A) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Cyclin-dependent kinase inhibitor 1(CDKN1A) ELISA kit
1-CSB-EL005086MO	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Cyclin-dependent kinase inhibitor 1(CDKN1A) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

ET-2 Antibody
35400-100ul	SAB	100ul	EUR 468

ET-3 antibody
22579-100ul	SAB	100ul	EUR 468

Diacylglycerol Kinase Inhibitor I
50R-R59022	Fitzgerald	50 mg	EUR 289.2
Description: Diacylglycerol Kinase Inhibitor I chemical reference substance

Aurora Kinase Inhibitor III
B7947-.5	ApexBio	500 µg	EUR 141.6
Description: Aurora Kinase Inhibitor III

Aurora Kinase Inhibitor III
B7947-5	ApexBio	5 mg	EUR 714
Description: Aurora Kinase Inhibitor III

Adenosine Kinase Inhibitor (hydrate)
C5282-10	ApexBio	10 mg	EUR 435.6
Description: IC50: 1.7 nM in cell-free assaysAdenosine Kinase Inhibitor is an inhibitor of adenosine kinase. Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations.

Adenosine Kinase Inhibitor (hydrate)
C5282-5	ApexBio	5 mg	EUR 360
Description: IC50: 1.7 nM in cell-free assaysAdenosine Kinase Inhibitor is an inhibitor of adenosine kinase. Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations.

DiscoveryProbe? Kinase Inhibitor Library
L1024-.25	ApexBio	250 uL/well(10 mM solution)	EUR 13394.4

DiscoveryProbe? Kinase Inhibitor Library
L1024-5	ApexBio	5 mg/well	EUR 17473.2

RIP2 kinase inhibitor 2
HY-19761	MedChemExpress	50mg	EUR 2539.2

Aurora Kinase Inhibitor 3
HY-112373	MedChemExpress	1mg	EUR 198

Apigenin (Protein kinase inhibitor)
SIH-249-10MG	Stressmarq	10 mg	EUR 127.2
Description: The substance Apigenin is a protein kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 50 mM in DMSO.

Apigenin (Protein kinase inhibitor)
SIH-249-50MG	Stressmarq	50 mg	EUR 255.6
Description: The substance Apigenin is a protein kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 50 mM in DMSO.

Staurosporine (Protein kinase inhibitor)
SIH-253-1MG	Stressmarq	1 mg	EUR 380.4
Description: The substance Staurosporine is a protein kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is pale yellow solid which is soluble to 50 mM in DMSO.

Staurosporine (Protein kinase inhibitor)
SIH-253-250UG	Stressmarq	250 µg	EUR 178.8
Description: The substance Staurosporine is a protein kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is pale yellow solid which is soluble to 50 mM in DMSO.

6BIO (PDK1 kinase inhibitor)
SIH-422-25MG	Stressmarq	25 mg	EUR 474
Description: The substance 6BIO is a pdk1 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is dark red solid which is soluble to 10 mM in DMSO and to 10 mM in ethanol.

6BIO (PDK1 kinase inhibitor)
SIH-422-5MG	Stressmarq	5 mg	EUR 178.8
Description: The substance 6BIO is a pdk1 kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is dark red solid which is soluble to 10 mM in DMSO and to 10 mM in ethanol.

AG1296 (PDGFR kinase inhibitor)
SIH-426-25MG	Stressmarq	25 mg	EUR 608.4
Description: The substance AG1296 is a pdgfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white to brownish solid which is soluble in DMSO or dichloromethane.

AG1296 (PDGFR kinase inhibitor)
SIH-426-5MG	Stressmarq	5 mg	EUR 205.2
Description: The substance AG1296 is a pdgfr kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white to brownish solid which is soluble in DMSO or dichloromethane.

CHIR99021 (GSK3? kinase inhibitor)
SIH-437-1MG	Stressmarq	1 mg	EUR 151.2
Description: The substance CHIR99021 is a gsk3? kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to light brown solid which is soluble to 20 mM in DMSO.

CHIR99021 (GSK3? kinase inhibitor)
SIH-437-5MG	Stressmarq	5 mg	EUR 246
Description: The substance CHIR99021 is a gsk3? kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to light brown solid which is soluble to 20 mM in DMSO.

Dorsomorphin (AMPK kinase inhibitor)
SIH-443-25MG	Stressmarq	25 mg	EUR 514.8
Description: The substance Dorsomorphin is a ampk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow solid which is soluble in DMSO (4 mg/ml, warm).

Dorsomorphin (AMPK kinase inhibitor)
SIH-443-5MG	Stressmarq	5 mg	EUR 184.8
Description: The substance Dorsomorphin is a ampk kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is yellow solid which is soluble in DMSO (4 mg/ml, warm).

Gefitinib (EGFR Kinase inhibitor)
SIH-445-250MG	Stressmarq	250 mg	EUR 360
Description: The substance Gefitinib is a egfr kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is solid which is soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C).

Gefitinib (EGFR Kinase inhibitor)
SIH-445-50MG	Stressmarq	50 mg	EUR 164.4
Description: The substance Gefitinib is a egfr kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is solid which is soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C).

Genistein (Tyrosine kinase inhibitor)
SIH-446-10MG	Stressmarq	10 mg	EUR 117.6
Description: The substance Genistein is a tyrosine kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is creamy off-white solid which is soluble in DMSO (30 mg/ml), 100% ethanol (4 mg/ml) or dilute aqueous base; insoluble in water.

Genistein (Tyrosine kinase inhibitor)
SIH-446-50MG	Stressmarq	50 mg	EUR 198
Description: The substance Genistein is a tyrosine kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is creamy off-white solid which is soluble in DMSO (30 mg/ml), 100% ethanol (4 mg/ml) or dilute aqueous base; insoluble in water.

GF109203X (PKC kinase inhibitor)
SIH-447-10MG	Stressmarq	10 mg	EUR 306
Description: The substance GF109203X is a pkc kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is red solid which is soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well).

GF109203X (PKC kinase inhibitor)
SIH-447-1MG	Stressmarq	1 mg	EUR 178.8
Description: The substance GF109203X is a pkc kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is red solid which is soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well).

GW2580 (cFMS kinase inhibitor)
SIH-449-25MG	Stressmarq	25 mg	EUR 447.6
Description: The substance GW2580 is a cfms kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble in DMSO: 10 mg/ml, clear (warmed) .

GW2580 (cFMS kinase inhibitor)
SIH-449-5MG	Stressmarq	5 mg	EUR 168
Description: The substance GW2580 is a cfms kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble in DMSO: 10 mg/ml, clear (warmed) .

Imatinib mesylate (Kinase inhibitor)
SIH-453-100MG	Stressmarq	100 mg	EUR 279.6
Description: The substance Imatinib mesylate is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble H2O: soluble10 mg/ml, clear .

Imatinib mesylate (Kinase inhibitor)
SIH-453-20MG	Stressmarq	20 mg	EUR 151.2
Description: The substance Imatinib mesylate is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to beige solid which is soluble H2O: soluble10 mg/ml, clear .

KT5720 (PKA kinase inhibitor)
SIH-457-100UG	Stressmarq	100 µg	EUR 246
Description: The substance KT5720 is a pka kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white powder which is soluble in methanol: clear colorless solution at 5 mg/ml.

KT5720 (PKA kinase inhibitor)
SIH-457-500UG	Stressmarq	500 µg	EUR 682.8
Description: The substance KT5720 is a pka kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white powder which is soluble in methanol: clear colorless solution at 5 mg/ml.

LYS6K2 (S6 kinase inhibitor)
SIH-462-25MG	Stressmarq	25 mg	EUR 582
Description: The substance LYS6K2 is a s6 kinase inhibitor. It is synthetically produced and has a purity of 0.97. The pure substance is yellow solid which is soluble in DMSO (up to 1 mg/ml) or DMF (up to 3 mg/ml with warming).

LYS6K2 (S6 kinase inhibitor)
SIH-462-5MG	Stressmarq	5 mg	EUR 205.2
Description: The substance LYS6K2 is a s6 kinase inhibitor. It is synthetically produced and has a purity of 0.97. The pure substance is yellow solid which is soluble in DMSO (up to 1 mg/ml) or DMF (up to 3 mg/ml with warming).

PD98059 (MEK kinase inhibitor)
SIH-466-25MG	Stressmarq	25 mg	EUR 514.8
Description: The substance PD98059 is a mek kinase inhibitor. It is synthetically produced and has a purity of ?95%. The pure substance is pale yellow solid which is soluble in DMSO (6.5 mg/ml); 25 mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6 mg/ml).

PD98059 (MEK kinase inhibitor)
SIH-466-5MG	Stressmarq	5 mg	EUR 184.8
Description: The substance PD98059 is a mek kinase inhibitor. It is synthetically produced and has a purity of ?95%. The pure substance is pale yellow solid which is soluble in DMSO (6.5 mg/ml); 25 mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6 mg/ml).

PP1 (Src kinase inhibitor)
SIH-469-25MG	Stressmarq	25 mg	EUR 742.8
Description: The substance PP1 is a src kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol.

PP1 (Src kinase inhibitor)
SIH-469-5MG	Stressmarq	5 mg	EUR 246
Description: The substance PP1 is a src kinase inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol.

PP2 (Src kinase inhibitor)
SIH-470-25MG	Stressmarq	25 mg	EUR 884.4
Description: The substance PP2 is a src kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (25 mg/ml).