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Oplosbare Antibody Stimulatieter onthuld door BOOST fosfotyrosine Proteomics

Chimère  antigeen  receptor  T-cellen (CAR-T-cellen) de toekomst in immunotherapie voor auto-immuunziekten?

Doelstelling:  CAR-T-celtherapie heeft een revolutie teweeggebracht in de behandeling van oncologische ziekten en recentelijk zijn mogelijke toepassingen bij auto-immuunziekten beschreven. De beoordeling heeft tot doel de beschikbare gegevens over de behandeling met CAR-T-cellen te integreren, met de nadruk op auto-immuunziekten, om de therapeutische vooruitgang en hun mogelijke toekomstige klinische toepasbaarheid bij auto-immuniteit te bepalen.

Materialen en methoden:  Er is gezocht in PubMed met de trefwoorden “Chimeric Antigen Receptor” en “CART cell”. De relevante documenten werden geselecteerd en de informatie werd kritisch bekeken.

Resultaten:  Bij de behandeling van auto-immuunziekten zijn in preklinische modellen drie verschillende cellulaire strategieën gebruikt, waaronder chimere antigeenreceptor T-cellen, chimere auto-antilichaamreceptor T-cellen en chimere antigeenreceptor in regulerende T-lymfocyten . Alle drie soorten therapie zijn effectief geweest. De mogelijke nadelige effecten daarin, het cytokine-afgiftesyndroom, cellulaire toxiciteit en neurotoxiciteit moeten altijd in gedachten worden gehouden.

Conclusies:  Hoewel er nog geen informatie over mensen beschikbaar is, laten preklinische modellen van CAR-T-cellen bij de behandeling van auto-immuunziekten veelbelovende resultaten zien, zodat ze in de toekomst een nuttige en effectieve therapie kunnen worden bij de behandeling van deze pathologieën.

Ovalbumine  Antigen -Specifieke Activatie van menselijke T-cel  -receptor  lijkt sterk op Oplosbare Antibody Stimulatieter onthuld door BOOST fosfotyrosine Proteomics

Activering van de T-celreceptor (TCR) leidt tot een netwerk van vroege signalering, voornamelijk georkestreerd door tyrosinefosforylering in T-cellen. De TCR wordt gewoonlijk geactiveerd met behulp van oplosbare anti-TCR-antilichamen, maar deze benadering is niet antigeenspecifiek. Als alternatief wordt aangenomen dat het activeren van de TCR met behulp van specifieke antigenen met een reeks bindingsaffiniteiten in de vorm van een peptide-major histocompatibiliteitscomplex (pMHC) meer fysiologisch is. Vanwege het ontbreken van grootschalige fosfotyrosine (pTyr) proteomische onderzoeken die anti-TCR-antilichamen en pMHC rechtstreeks vergelijken, blijft een uitgebreide definitie van deze geactiveerde toestanden echter raadselachtig.

Opheldering van het tyrosinefosfoproteoom met behulp van kwantitatieve pTyr-proteomics maakt een beter begrip mogelijk van de unieke kenmerken van deze activerende middelen en de rol van ligandbindingsaffiniteit op signalering. Hier passen we de latest opgerichte breedspectrumoptimalisatie van selectieve triggering (BOOST) toe om verstoringen in tyrosinefosforylering van menselijke TCR te onderzoeken, veroorzaakt door anti-TCR-antilichamen en pMHC. Onze gegevens laten zien dat pMHC-activering met hoge affiniteit ovalbumine (OVA) van de menselijke TCR een grotendeels vergelijkbare, zij het mogelijk sterkere, pTyr-gemedieerdesignaalregulerende as vergeleken met het anti-TCR-antilichaam. De signaleringsoutput die resulteert uit OVA pMHC-varianten correleert goed met hun zwakkere affiniteiten, waardoor affiniteit-afstembare controle van de signaalsterkte mogelijk is. Gezamenlijk bieden we een raamwerk voor het toepassen van BOOST om pTyr-gemedieerde signaalroutes van menselijke T-cellen te vergelijken die op een antigeenonafhankelijke en antigeenspecifieke manier zijn geactiveerd.

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HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations)

801002 96 Determinations
EUR 574

HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations)

0801002 96T
EUR 603

HIV-1 p17-p24 recombinant antigen.

00172-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 p17-p24 recombinant antigen.

HIV-1 p17-p24 recombinant antigen.

00172-V 1 MG
EUR 850

HIV-1 GAG P24 Recombinant Antigen

00111-V-01mg 0,1 mg
EUR 321
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen

00111-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV 1 p24 core recombinant antigen

00177-V-01mg 0,1 mg
EUR 321
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen

00177-V-1000ug 1000 ug
EUR 1539
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen.

00177-V-100ugvial 100ug/vial
EUR 150
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen.

00177-V 1 MG
EUR 850

HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations)

0801200 5 X 96T
EUR 2563

HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations)

801200 5 X 96 Determinations
EUR 2330

HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations)

801008 5 X 96 Determinations
EUR 2386

HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations)

0801008 5 X 96T
EUR 2505

Human HIV(1+2 antibodies plus p24 antigen (4th Generation) ELISA Kit

EH4101 96T
EUR 571.5
Description: Method of detection: Qualitative ;Reacts with: Homo sapiens;Sensitivity: Qualitative

Mouse Anti Human Immunodeficiency Virus (HIV-1) p24 (1947)

MAB12321-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for HIV-1 p24

Mouse Anti Human Immunodeficiency Virus (HIV-1) p24 (1947)

MAB12321-500 0.5
EUR 671.04
Description: Mouse monoclonal antibody specific for HIV-1 p24

Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit

NSL1389Hu 96 wells
EUR 468

Human Immunodeficiency Virus p24 Protein [HIV-1/Clade B]

REC31743-100 0.1
EUR 496.27
Description: Recombinant HIV p24 protein (NCBI accession number ABO61536, AA35-265, L40I) produced in HEK293 cells. Protein carries a C-terminal His-tag.. Protein was purified by immobilised metal affinity and ion exchange chromatography from the pellet of transfected cells.

Human Immunodeficiency Virus p24 Protein [HIV-1/Clade B]

REC31743-500 0.5
EUR 1363.78
Description: Recombinant HIV p24 protein (NCBI accession number ABO61536, AA35-265, L40I) produced in HEK293 cells. Protein carries a C-terminal His-tag.. Protein was purified by immobilised metal affinity and ion exchange chromatography from the pellet of transfected cells.

HIV-1 p24 ELISA Kit

Z7040001 1 kit
EUR 752

Bovine HIV-1 p24 core protein(HIV-1 p24) Anti-body ELISA Kit

NSL1181Bo 96 T
EUR 528

OPEF01414-1MG - Recombinant Human Immunodeficiency Virus 1 (HIV 1-p24) Antigen

OPEF01414-1MG 1mg
EUR 2216

Human HIV (1+2) antigen&antibody ELISA Kit

AE62582HU-48Tests 48 Tests
EUR 360
Description: Human (Homo sapiens)

Human HIV (1+2) antigen&antibody ELISA Kit

AE62582HU-96Tests 96 Tests
EUR 680
Description: Human (Homo sapiens)

HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

00111-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

00111-V 1 MG
EUR 850

HIV-1 p17/24/gp120 antigen

00169-V-01mg 0,1 mg
EUR 321
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

HIV-1 p17/24/gp120 antigen

00169-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

HIV-1 intergase antigen

00199-V-01mg 0,1 mg
EUR 321
Description: HIV-1 intergase antigen. The protein contains the HIV-1 immunodominant regions from pol protein (integrase).

HIV-1 intergase antigen

00199-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 intergase antigen. The protein contains the HIV-1 immunodominant regions from pol protein (integrase).

Astrovirus Antigen (Type 1)

AS02-1000 1.0
EUR 1654.65
Description: A concentrated source of Astrovirus particles and Astrovirus proteins from a lysate of host cells.

Astrovirus Antigen (Type 1)

AS02-200 0.2
EUR 442.69
Description: A concentrated source of Astrovirus particles and Astrovirus proteins from a lysate of host cells.

Canine Adenovirus 1 Antigen

NAT41587-100 0.1
EUR 391.66
Description: Canine Adenovirus Type 1, produced in A-72 cells.

Herpes Simplex Virus 1 Antigen

HS105-1000 1.0
EUR 1178.79
Description: HSV-1 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

Herpes Simplex Virus 1 Antigen

HS105-200 0.2
EUR 294.7
Description: HSV-1 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

HIV-1 p24 Antibody

20-abx137062
  • EUR 427.20
  • EUR 627.60
  • 0.5 mg
  • 1 mg

HIV-1 p24 Antibody

7313-002mg 0.02 mg
EUR 206.18
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains.

HIV-1 p24 Antibody

7313-01mg 0.1 mg
EUR 523.7
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains.

HIV-1 p24 Antibody

abx021869-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021870-1mg 1 mg
EUR 760.8

HIV-1 p24 Antibody

abx021871-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021872-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021873-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021882-1mg 1 mg
EUR 1178.4

HIV-1 p24 Antibody

abx021883-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx021886-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx021887-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx021888-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx023027-1ml 1 ml
EUR 693.6

HIV-1 p24 Antibody

abx023925-1mg 1 mg
EUR 828

HIV-1 p24 Antibody

abx023926-1mg 1 mg
EUR 828

HIV-1 p24

E5-00024 1mg
EUR 1152

HIV-1 p24

E62H002 100ug
EUR 458.4

HIV-1 p24

ant-152 0.5mg
EUR 275
Description: Mouse Anti HIV-1 p24

HIV-1 p24

hiv-006 100µg
EUR 130
Description: Recombinant HIV-1 p24

Canine Adenovirus 1 and 2 Antigen

NAT41589-100 0.1
EUR 391.66
Description: A mixture of Canine Adenovirus Type 1 and Type 2, produced in A-72 cells.

HIV-1 tat recombinant antigen

00110-V-01mg 0,1 mg
EUR 321
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 tat recombinant antigen

00110-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 nef recombinant antigen

00112-V-01mg 0,1 mg
EUR 321
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 nef recombinant antigen

00112-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 gag recombinant antigen

8934 100 ug
EUR 542.86
Description: This is HIV-1 gag recombinant antigen for ELISA,WB.

HIV-1 nef recombinant antigen

8941 100 ug
EUR 477.6
Description: This is HIV-1 nef recombinant antigen for ELISA,WB.

Herpes Simplex Virus 1 Lysate Antigen

HS104-1000 1.0
EUR 270.46
Description: A high concentration of HSV-1 particles and proteins from a clarified cell lysate.

HIV-1 gp41 recombinant antigen,

00170-V-01mg 0,1 mg
EUR 321
Description: HIV-1 gp41 recombinant antigen.

HIV-1 gp41 recombinant antigen,

00170-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 gp41 recombinant antigen.

HIV-1 gp41 recombinant antigen

8908 100 ug
EUR 673.36
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen

8933 100 ug
EUR 477.6
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen

9000 100 ug
EUR 484.13
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen

9001 100 ug
EUR 484.13
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen.

00170-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 gp41 recombinant antigen.

HIV-1 gp41 recombinant antigen.

00170-V 1 MG
EUR 850

Leptospira Biflexa Antigen (Strain Patoc 1)

NAT41582-100 0.1
EUR 391.66
Description: Inactivated Leptospira biflexa antigen (Strain Patoc 1) from broth culture.

Leptospira Biflexa Antigen (Strain Patoc 1)

NAT41582-500 0.5
EUR 1176.24
Description: Inactivated Leptospira biflexa antigen (Strain Patoc 1) from broth culture.

Mouse Anti Human Immunodeficiency Virus (HIV-1) p17 (1981)

MAB12320-100 0.1
EUR 310.01
Description: Mouse monoclonal antibody specific for HIV-1 p17

Mouse Anti Human Immunodeficiency Virus (HIV-1) p17 (1981)

MAB12320-500 0.5
EUR 770.55
Description: Mouse monoclonal antibody specific for HIV-1 p17

HIV p24 Antibody

abx021867-1mg 1 mg
EUR 1612.8

HIV p24 Antibody

abx021868-1mg 1 mg
EUR 1612.8

Borrelia Afzelii Antigen

NAT41583-100 0.1
EUR 391.66
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Borrelia Afzelii Antigen

NAT41583-500 0.5
EUR 1176.24
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Borrelia Garinii Antigen

NAT41584-100 0.1
EUR 391.66
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Borrelia Garinii Antigen

NAT41584-500 0.5
EUR 1176.24
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Brucella Abortus Antigen

NAT41599-100 0.1
EUR 391.66
Description: Brucella abortus lysate, produced by fermentation.

Brucella Abortus Antigen

NAT41599-500 0.5
EUR 1176.24
Description: Brucella abortus lysate, produced by fermentation.

Candida Albicans Antigen

NAT41601-100 0.1
EUR 391.66
Description: Candida albicans is grown on solid medium, washed, disrupted and subjected to an extraction process. The antigen consists of cytoplasmic and cell wall components.

Candida Albicans Antigen

NAT41601-500 0.5
EUR 1176.24
Description: Candida albicans is grown on solid medium, washed, disrupted and subjected to an extraction process. The antigen consists of cytoplasmic and cell wall components.

Canine Parvovirus Antigen

NAT41594-100 0.1
EUR 391.66
Description: Canine Parvovirus, produced in CRFK cells.

Canine Coronavirus Antigen

NAT41590-100 0.1
EUR 391.66
Description: Canine Coronavirus produced in A-72 cells.

Feline Calicivirus Antigen

NAT41595-100 0.1
EUR 391.66
Description: Feline Calicivirus produced in FC 3TG cells.

HIV-1 p17/24/gp120-gp41 recombinant antigen,

00168-V-01mg 0,1 mg
EUR 321
Description: HIV-1 p17/24/gp120-gp41 recombinant antigen.

HIV-1 p17/24/gp120-gp41 recombinant antigen,

00168-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 p17/24/gp120-gp41 recombinant antigen.

HIV-1 p17/24/gp120-gp41 recombinant antigen.

00168-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 p17/24/gp120-gp41 recombinant antigen.

HIV-1 p17/24/gp120-gp41 recombinant antigen.

00168-V 1 MG
EUR 850

Helicobacter Pylori Antigen

NAT41603-100 0.1
EUR 391.66
Description: Bacteria are cultured on solid medium, harvested, washed and solubilised. The antigen is partially purified by detergent extraction and centrifugation.

Helicobacter Pylori Antigen

NAT41603-500 0.5
EUR 1176.24
Description: Bacteria are cultured on solid medium, harvested, washed and solubilised. The antigen is partially purified by detergent extraction and centrifugation.

Campylobacter Jejuni Antigen

NAT41600-100 0.1
EUR 391.66
Description: Campylobacter jejuni is cultured on solid medium. This antigen is a partially purified detergent extract of the membrane fraction. The main component is an outer membrane protein, approximately 45 kDa in SDS-PAGE.

Campylobacter Jejuni Antigen

NAT41600-500 0.5
EUR 1176.24
Description: Campylobacter jejuni is cultured on solid medium. This antigen is a partially purified detergent extract of the membrane fraction. The main component is an outer membrane protein, approximately 45 kDa in SDS-PAGE.

HIV-1 p24 Antibody (HRP)

abx023029-1ml 1 ml
EUR 886.8

HIV-1 p24 Antibody [8G9]

PM-6335-002mg 0.02 mg
EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9]

PM-6335-01mg 0.1 mg
EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4]

PM-6585-002mg 0.02 mg
EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4]

PM-6585-01mg 0.1 mg
EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV 1 envelope recombinant antigen

00176-V-01mg 0,1 mg
EUR 321
Description: HIV 1 envelope recombinant antigen. HIV-1 evnelope protein spanning the C-Terminus of gp 120 and most of gp 41.

HIV 1 envelope recombinant antigen

00176-V-1000ug 1000 ug
EUR 1539
Description: HIV 1 envelope recombinant antigen. HIV-1 evnelope protein spanning the C-Terminus of gp 120 and most of gp 41.

HIV-1 p24 Antibody (FITC)

abx021884-100ug 100 ug
EUR 886.8

HIV-1 p24 Antibody (FITC)

abx023026-1ml 1 ml
EUR 678

Echovirus Antigen, Recombinant

REC31776-100 0.1
EUR 276.84
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus

Echovirus Antigen, Recombinant

REC31776-500 0.5
EUR 1043.56
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus

Neisseria Gonorrhoeae Antigen

NG01-1000 1.0
EUR 378.9
Description: Homogenised lysate of pure bacteria.

Chlamydia Trachomatis Antigen

CT022-1000 1.0
EUR 378.9
Description: Chlamydia trachomatis antigens from clarified cell lysate.

Mycoplasma Pneumoniae Antigen

MP901-1000 1.0
EUR 1010.39
Description: Mycoplasma pneumoniae whole organisms that have been purified and detergent treated to enrich antigenic proteins and decrease background.

Mycoplasma Pneumoniae Antigen

MP901-200 0.2
EUR 270.46
Description: Mycoplasma pneumoniae whole organisms that have been purified and detergent treated to enrich antigenic proteins and decrease background.

Trichomonas Vaginalis Antigen

TV01-1000 1.0
EUR 421
Description: Washed & lysed suspension of whole protozoa

HIV 1 / 2 p24 Antibody

abx021866-1mg 1 mg
EUR 1212

HIV 1 / 2 p24 Antibody

abx021890-1mg 1 mg
EUR 1212

HIV-1 p24 Antibody (Biotin)

abx023028-1ml 1 ml
EUR 794.4

Enterovirus Antigen, Recombinant

REC31772-100 0.1
EUR 276.84
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus IgA, IgG and IgM ELISA.

Enterovirus Antigen, Recombinant

REC31772-500 0.5
EUR 1043.56
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus IgA, IgG and IgM ELISA.

Echinococcus Granulosus Antigen

NAT41602-100 0.1
EUR 391.66
Description: Echinococcus granulosus material is derived from bovine hydatid cyst as sterile filtered cyst fluid.

Echinococcus Granulosus Antigen

NAT41602-500 0.5
EUR 1176.24
Description: Echinococcus granulosus material is derived from bovine hydatid cyst as sterile filtered cyst fluid.

HIV-1 env gp41 recombinant antigen

00113-V-01mg 0,1 mg
EUR 321
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 env gp41 recombinant antigen

00113-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

Cytomegalovirus Purified Antigen

CMV-HP-100 0.1
EUR 318.94
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation.

Cytomegalovirus Purified Antigen

CMV-HP-1000 1.0
EUR 2096.06
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation.

Cytomegalovirus Purified Antigen

CMV-HP-500 0.5
EUR 1279.58
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation.

Yersinia pestis V antigen

REC32028-100 0.1
EUR 491.53
Description: Yersinia pestis V antigen (LcrV antigen, capsule protein fraction 1, type III secretion system needle tip protein). The protein is produced as an N-terminal GST fusion, with GST being cleaved by thrombin and is not present in the final product.

Yersinia pestis V antigen

REC32028-500 0.5
EUR 2421.37
Description: Yersinia pestis V antigen (LcrV antigen, capsule protein fraction 1, type III secretion system needle tip protein). The protein is produced as an N-terminal GST fusion, with GST being cleaved by thrombin and is not present in the final product.

HIV-1 p17/p24

PR-1207 100µg
EUR 300.7
Description: recombinant, E. coli

HIV-1 gp41 Long recombinant antigen,

00171-V-01mg 0,1 mg
EUR 321
Description: HIV-1 gp41 Long recombinant antigen.

HIV-1 gp41 Long recombinant antigen,

00171-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 gp41 Long recombinant antigen.

HIV-1 gp41 Long recombinant antigen.

00171-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 gp41 Long recombinant antigen.

HIV-1 gp41 Long recombinant antigen.

00171-V 1 MG
EUR 850

Polyclonal HIV-1 p24 Antibody

APR11116G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIV-1 p24 . This antibody is tested and proven to work in the following applications:

Canine Herpes Virus Antigen

NAT41592-100 0.1
EUR 391.66
Description: Canine Herpes virus, produced in MDCK cells.

Canine Adenovirus 2 Antigen

NAT41588-100 0.1
EUR 391.66
Description: Canine Adenovirus Type 2, produced in A-72 cells.

Canine Distemper Virus Antigen

NAT41591-100 0.1
EUR 391.66
Description: Canine Distemper virus, produced in SL-29 cells.

ToX Antigen (P24,GRA1)

E61Y00305 1mg
EUR 840

HIV-1 p24 gag

hiv-123 100µg
EUR 165
Description: Recombinant HIV-I p24 gag

HIV-1 p24 His

hiv-159 5µg
EUR 60
Description: Recombinant HIV-1 p24 His Tag

Norovirus GII.4 VP1 Antigen

REC31620-100 0.1
EUR 302.36
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells.

Norovirus GII.4 VP1 Antigen

REC31620-1000 1.0
EUR 1830.71
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells.

Norovirus GII.4 VP1 Antigen

REC31620-500 0.5
EUR 1066.53
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells.

HIV-1 p24 core

PR-1231 100µg
EUR 300.7
Description: recombinant, E. coli

Canine Parainfluenza Virus Antigen

NAT41593-100 0.1
EUR 391.66
Description: Canine Parainfluenza virus antigen, produced in MDCK cells.

Feline Panleukopenia Virus Antigen

NAT41597-100 0.1
EUR 391.66
Description: Feline Panleukopenia Virus (FPLV; feline parvovirus) antigen, produced in CRFK cells.

HIV-1 p24 24kDa

hiv-155 2µg
EUR 60
Description: Recombinant HIV-1 p24 , 24kDa

Cytomegalovirus Cell Lysate Antigen

CMV-CL-100 0.1
EUR 223.26
Description: A clarified cell lysate containing a mix of CMV antigens from all stages of the replication life cycle.

Cytomegalovirus Cell Lysate Antigen

CMV-CL-1000 1.0
EUR 1422.47
Description: A clarified cell lysate containing a mix of CMV antigens from all stages of the replication life cycle.

HIV-1 p24 Paired

ant-772 100µg
EUR 200
Description: Mouse Anti HIV-1 p24 Paired

Feline Viral Rhinotracheitis Antigen

NAT41598-100 0.1
EUR 391.66
Description: Feline Viral Rhinotracheitis (FVR; feline herpes virus, FHV-1) antigen, produced in CRFK cells.

HIV-1 p24 Protein

20-abx261886
  • EUR 5388.00
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

HIV-1 p24 Protein

abx169032-1mg 1 mg
EUR 661.2

HIV-1 p24 Protein

abx061424-05mg 0.5 mg
EUR 886.8

HIV-1, p24 Protein

abx069857-1mg 1 mg
EUR 1888.8

HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

00169-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

00169-V 1 MG
EUR 850

Herpes Simplex Virus 2 Antigen

HS205-1000 1.0
EUR 1178.79
Description: HSV-2 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

Herpes Simplex Virus 2 Antigen

HS205-200 0.2
EUR 294.7
Description: HSV-2 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

HIV-1 Gag p24

05-005 50 ug
EUR 434.4
Description: The HIV-1 Gag p24 is available in Europe and for worldwide shipping via Gentaur.

HIV-1 Gag p24

05-006 250 ug
EUR 1154.4
Description: The HIV-1 Gag p24 is available in Europe and for worldwide shipping via Gentaur.

Recombinant HIV-1 p24

7-07603 100µg Ask for price

Recombinant HIV-1 p24

7-07604 500µg Ask for price

Recombinant HIV-1 p24

7-07605 1000µg Ask for price

HIV 1 p24 Protein

abx060589-1mg 1 mg
EUR 1545.6

Ross River Virus Recombinant Antigen

REC31969-100 0.1
EUR 757.8
Description: Recombinant Ross River virus antigen expressed in HEK293 cells as virus-like particles and purified by sucrose density gradients and precipitation. Virus-like particles were then solubilized in PBS containing 0.2% SDS to prevent aggregation of particles. The preparation is not particulate. Antigens in the preparation include Envelope proteins 1 and 2 and Nucleoprotein.

Ross River Virus Recombinant Antigen

REC31969-500 0.5
EUR 2844.92
Description: Recombinant Ross River virus antigen expressed in HEK293 cells as virus-like particles and purified by sucrose density gradients and precipitation. Virus-like particles were then solubilized in PBS containing 0.2% SDS to prevent aggregation of particles. The preparation is not particulate. Antigens in the preparation include Envelope proteins 1 and 2 and Nucleoprotein.

HIV-1 reverse transcriptase recombinant antigen

00198-V-01mg 0,1 mg
EUR 321
Description: HIV-1 reverse transcriptase recombinant antigen.

HIV-1 reverse transcriptase recombinant antigen

00198-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 reverse transcriptase recombinant antigen.

HIV-1 reverse transcriptase recombinant antigen.

00198-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 reverse transcriptase recombinant antigen.

HIV-1 reverse transcriptase recombinant antigen.

00198-V 1 MG
EUR 850

HIV 1, 2 envelope recombinant antigen

00175-V-01mg 0,1 mg
EUR 321
Description: HIV 1, 2 envelope recombinant antigen. HIV-1 envelope conjugated to HIV-2 envelope peptide.

HIV 1, 2 envelope recombinant antigen

00175-V-1000ug 1000 ug
EUR 1539
Description: HIV 1, 2 envelope recombinant antigen. HIV-1 envelope conjugated to HIV-2 envelope peptide.

HIV-1 clade O gp140

REC32082-100 0.1
EUR 463.1
Description: HIV-1 clade O gp140 produced in HEK293 cells and purified from culture supernatant. The protein contains three amino acid substitutions I499C, I561P, Y606C. In addition, the furin cleavage site was enhanced from “RTHREKR” to “RRRRRR” .The furin processing is partial in HEK293 cells, and the prtoein is presented as a mix of cleaved and uncleaved protein.

HIV-1 clade O gp140

REC32082-500 0.5
EUR 463.1
Description: HIV-1 clade O gp140 produced in HEK293 cells and purified from culture supernatant. The protein contains three amino acid substitutions I499C, I561P, Y606C. In addition, the furin cleavage site was enhanced from “RTHREKR” to “RRRRRR” .The furin processing is partial in HEK293 cells, and the prtoein is presented as a mix of cleaved and uncleaved protein.

Hepatitis B Virus E Antigen (HBeAg)

REC31677-100 0.1
EUR 456.72
Description: Recombinant Hepititis B Virus E Protein (HBeAg).

Hepatitis B Virus E Antigen (HBeAg)

REC31677-500 0.5
EUR 1941.06
Description: Recombinant Hepititis B Virus E Protein (HBeAg).

HIV Type-1 p24 Antibody

V2344-100UG 100 ug
EUR 349.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody

V2344-20UG 20 ug
EUR 153.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody

V2344CF488-100T 100 Tests
EUR 349.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody

V2344SAF-100UG 100 ug
EUR 349.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

Hepatitis B Virus Core Antigen (HBcAg)

REC31689-100 0.1
EUR 456.72
Description: Recombinant Hepititis B Virus Core Protein (HBcAg).

Hepatitis B Virus Core Antigen (HBcAg)

REC31689-500 0.5
EUR 1370.16
Description: Recombinant Hepititis B Virus Core Protein (HBcAg).

Hepatitis C Virus Core Antigen (HCcAg)

REC31693-100 0.1
EUR 484.79
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag.

Hepatitis C Virus Core Antigen (HCcAg)

REC31693-500 0.5
EUR 1455.64
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag.

Herpes Simplex Virus 2 Lysate Antigen

HS204-1000 1.0
EUR 270.46
Description: A high concentration of HSV-2 particles and proteins from a clarified cell lysate.

Feline Infectious Peritonitis Virus Antigen

NAT41596-100 0.1
EUR 391.66
Description: Feline Infectious Peritonitis virus (FIPV; feline coronavirus) antigen, produced in CRFK cells.

HIV-1 p24 Antibody [8G9] (HRP)

PM-6335-HRP-002mg 0.02 mg
EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9] (HRP)

PM-6335-HRP-01mg 0.1 mg
EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (HRP)

PM-6585-HRP-002mg 0.02 mg
EUR 206.18
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (HRP)

PM-6585-HRP-01mg 0.1 mg
EUR 523.7
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

Bilaterale anterior cerebrale slagader occlusie na CD19- en BCMA-gerichte chimere  antigeen  receptor  van T-celtherapie voor een patiënt myeloom

Chimere antigeenreceptor T (CAR-T)-celtherapie is een veelbelovende behandeling voor recidiverend/refractair multipel myeloom (RRMM). In ons vorige rapport was CD19- en BCMA-gerichte gelijktijdige toediening van CAR-T geassocieerd met een hoog responspercentage. Hoewel cytokine launch syndrome (CRS) en neurotoxiciteit frequente complicaties zijn na behandeling met CAR-T, wordt een herseninfarct zelden gerapporteerd als een CAR-T-gerelateerde complicatie. We rapporteerden een 73-jarige vrouwelijke MM-patiënt die CD19- en BCMA-gerichte CAR-T ontving voor refractaire ziekte.

Haar ziekte reageerde op CAR-T- therapie, maar ze ontwikkelde neurologische symptomen na CRS. Craniale CT en MRI toonden meerdere herseninfarcten en bilaterale anterieure cerebrale arterie (ACA) occlusie aan. We suggereren dat een ander herseninfarct dan CAR-T-gerelateerde neurotoxiciteit de onderliggende oorzaak is van abnormale neuropsychologische symptomen, en diagnostische beeldvormingstests moeten actief worden uitgevoerd om ischemische cerebrovasculaire gebeurtenissen uit te sluiten.

Het intracellulaire domein van CD40 is een krachtige Costimulatoire Ingredient in chimère  Antigen  Receptoren

De co-stimulerende domeinen die zijn ingebouwd in chimere antigeenreceptoren (CAR’s) van de tweede generatie en de derde generatie, hebben een sterke invloed op de functie van CAR-T-cellen . Hier hebben we CAR’s van de tweede generatie en de derde generatie onderzocht die het signaleringsdomein van de CD40-receptor herbergen als een nieuw costimulerend component in vergelijking met vergelijkbare CAR’s die het 4-1BB-domein dragen . In CAR’s van beide generaties was CD40 krachtiger dan 4-1BB bij het triggeren van de NF-KB-signaleringsroute.

In humane T-cellen van 2 donoren was CD40 vergelijkbaar met 4-1BB bij het opreguleren van co-stimulerende en activatiemarkers, het induceren van pro-inflammatoire cytokinesecretie en het mediëren van het doden van doelwitcellen. Interessant genoeg waren er duidelijk verschillen in het responspatroon van T-cellen van de 2 donoren met betrekking tot CD40 en 4-1BB. We concluderen dat in menselijke T-cellen het CD40- signaleringsdomein een krachtig co-stimulerend component is in CAR’s van zowel de tweede generatie als de derde generatie.

Een systematische herziening van de rol van chimere  Antigeen  Receptor  T (CAR-T) celtherapie bij de behandeling van solide tumoren

Chimere antigeenreceptor T (CAR-T) celtherapie maakt gebruik van de eigen T-lymfocyten van de patiënt die zijn ontworpen om kankercellen aan te vallen. Het is door de Meals and Drug Administration (FDA) goedgekeurd voor verschillende hematologische maligniteiten en wordt momenteel geëvalueerd bij solide kankers in vroege fase-onderzoeken. We deden een systematische evaluate bestaande uit 15 prospectieve klinische onderzoeken (n = 159) die CAR-T-cellen in solide kankers evalueerden . Vroege fase-onderzoeken toonden veelbelovende responspercentages bij ovariumepitheelkanker (100%), humaan epidermale groeifactorreceptor  (HER2)-positief sarcoom (67%) , epidermale groeifactorreceptor (EGFR)-positieve galwegkanker (65%), gevorderde maag-/pancreaskanker (82%), hepatocellulair carcinoom (67%),en colorectale kanker (70%) .

De mediane algehele respons voor alle maligniteiten was 62% (bereik 17%-100%) . De mediane progressievrije overleving en de totale overleving werden in de meeste onderzoeken niet bereikt. Cytokine-afgiftesyndroom werd gezien bij slechts één patiënt met cholangiocarcinoom die EGFR-specifieke CAR-T-celtherapie kreeg. Hoewel de overlevingsgegevens nog steeds niet volgroeid zijn, liet CAR-T-celtherapie bij solide maligniteiten bemoedigende responspercentages zien en werd goed verdragen.

Verschillen in lymfoompatiënten tussen chimeer  antigeen  receptor  van T-cel therapeutische proeven en bevolking

Chimere antigeenreceptor (CAR)-T-celtherapieën lijken veelbelovende behandelingen te zijn voor non-Hodgkin- en B-cellymfoom. Verschillende CAR-T-therapieën die zijn goedgekeurd door de Amerikaanse Meals and Drug Administration, zijn echter alleen op werkzaamheid getest in relatief weinig klinische onderzoeken met een enkele arm met kleine steekproefomvang. We probeerden de verschillen tussen patiënten in deze onderzoeken en de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom te onderzoeken. Vijfhonderdtweeëntwintig patiënten uit 15 CAR-T-onderzoeken gevonden in een systematische evaluate en 417.492 patiënten uit de Surveillance, Epidemiology, and Finish Outcomes (SEER) Program-database werden vergeleken.

De deelnemers aan de CAR-T-studie leken jonger (46,7% jonger dan 70 jaar vs. 42,2%) , meer mannelijk (68,0% vs. 55,7%) en werden gedurende een kortere periode gevolgd in vergelijking met patiënten in de SEER-populatie (gemiddelde [M] 45,6 maanden, 95% betrouwbaarheidsinterval [BI] 17,7 tot 63,three maanden follow-up vs. M 57,1 maanden, 95% BI 57,Zero tot 57,three maanden overleving). Deelnemers aan de CAR-T-studie kunnen aanzienlijk verschillen van de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom . De effectiviteit van CAR-T-therapieën bij de algemene populatie van lymfoompatiënten kan verschillen van de effectiviteit die is aangetoond in onderzoeken. Nieuw gecreëerde CAR-T-patiëntenregisters zijn essentieel om de effectiviteit van de therapieën op populatieniveau huge te stellen.

 

TAO Kinase inhibitor 1

T16987-10mg 10mg Ask for price
Description: TAO Kinase inhibitor 1

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Description: TAO Kinase inhibitor 1

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T12725-10mg 10mg Ask for price
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EGFR kinase inhibitor 1

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Description: Pim-1 kinase inhibitor 1

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PDGFRα kinase inhibitor 1

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Description: PDGFRα kinase inhibitor 1

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Description: PDGFRα kinase inhibitor 1

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Description: Pim-1 kinase inhibitor 3

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Description: Pim-1 kinase inhibitor 3

Pim-1/2 kinase inhibitor 1

T9229-10mg 10mg Ask for price
Description: Pim-1/2 kinase inhibitor 1

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Description: Pim-1/2 kinase inhibitor 1

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Description: Pim-1/2 kinase inhibitor 1

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Description: Pim-1/2 kinase inhibitor 1

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Description: Pim-1/2 kinase inhibitor 1

Pan-RAF kinase inhibitor 1

T63386-10mg 10mg Ask for price
Description: Pan-RAF kinase inhibitor 1

Pan-RAF kinase inhibitor 1

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Description: Pan-RAF kinase inhibitor 1

Pan-RAF kinase inhibitor 1

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Description: Pan-RAF kinase inhibitor 1

Pan-RAF kinase inhibitor 1

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Description: Pan-RAF kinase inhibitor 1

Pan-RAF kinase inhibitor 1

T63386-5mg 5mg Ask for price
Description: Pan-RAF kinase inhibitor 1

EML4-ALK kinase inhibitor 1

T11184-10mg 10mg Ask for price
Description: EML4-ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1

T11184-1g 1g Ask for price
Description: EML4-ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1

T11184-1mg 1mg Ask for price
Description: EML4-ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1

T11184-50mg 50mg Ask for price
Description: EML4-ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1

T11184-5mg 5mg Ask for price
Description: EML4-ALK kinase inhibitor 1

Protein kinase D inhibitor 1

T61163-10mg 10mg Ask for price
Description: Protein kinase D inhibitor 1

Protein kinase D inhibitor 1

T61163-1g 1g Ask for price
Description: Protein kinase D inhibitor 1

Protein kinase D inhibitor 1

T61163-1mg 1mg Ask for price
Description: Protein kinase D inhibitor 1

Protein kinase D inhibitor 1

T61163-50mg 50mg Ask for price
Description: Protein kinase D inhibitor 1

Protein kinase D inhibitor 1

T61163-5mg 5mg Ask for price
Description: Protein kinase D inhibitor 1

AKT Kinase Inhibitor

A3150-10 10 mg
EUR 1363.2
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor

A3150-5 5 mg
EUR 819.6
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor

A3150-5.1 10 mM (in 1mL DMSO)
EUR 895.2
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor

HY-10249A 10mg
EUR 1052.4

AKT Kinase Inhibitor

T10276-10mg 10mg Ask for price
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor

T10276-1g 1g Ask for price
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor

T10276-1mg 1mg Ask for price
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor

T10276-50mg 50mg Ask for price
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor

T10276-5mg 5mg Ask for price
Description: AKT Kinase Inhibitor

Tie2 Kinase Inhibitor

B1338-25 each
EUR 907.2

Tie2 Kinase Inhibitor

B1338-5 each
EUR 314.4

Tie2 kinase inhibitor

A5979-100 100 mg
EUR 1452
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor

A5979-25 25 mg
EUR 477.6
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor

A5979-5 5 mg
EUR 199.2
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor

A5979-5.1 10 mM (in 1mL DMSO)
EUR 536.4
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor

E1KS1577 10mg
EUR 1849.2

Sorafenib (Raf-1 kinase inhibitor)

SIH-476-10MG 10 mg
EUR 145.2
Description: The substance Sorafenib is a raf-1 kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is off white powder which is soluble inDMSO (200mg/ml) or ethanol (3mg/ml).

Sorafenib (Raf-1 kinase inhibitor)

SIH-476-50MG 50 mg
EUR 346.8
Description: The substance Sorafenib is a raf-1 kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is off white powder which is soluble inDMSO (200mg/ml) or ethanol (3mg/ml).

K252A (Kinase inhibitor)

SIH-455-100UG 100 µg
EUR 157.2
Description: The substance K252A is a kinase inhibitor. It is nonomuraea longicatena and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in DMSO.

K252A (Kinase inhibitor)

SIH-455-1MG 1 mg
EUR 358.8
Description: The substance K252A is a kinase inhibitor. It is nonomuraea longicatena and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in DMSO.

K252B (Kinase inhibitor)

SIH-456-100UG 100 µg
EUR 218.4
Description: The substance K252B is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml).

K252B (Kinase inhibitor)

SIH-456-1MG 1 mg
EUR 682.8
Description: The substance K252B is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml).

MAPKII Kinase Inhibitor

abx076811-1mg 1 mg
EUR 376.8

Tyrosine kinase inhibitor

HY-10421 25mg
EUR 459.6

Tyrosine kinase inhibitor

T17184-10mg 10mg Ask for price
Description: Tyrosine kinase inhibitor

Tyrosine kinase inhibitor

T17184-1g 1g Ask for price
Description: Tyrosine kinase inhibitor

Tyrosine kinase inhibitor

T17184-1mg 1mg Ask for price
Description: Tyrosine kinase inhibitor

Tyrosine kinase inhibitor

T17184-50mg 50mg Ask for price
Description: Tyrosine kinase inhibitor

Tyrosine kinase inhibitor

T17184-5mg 5mg Ask for price
Description: Tyrosine kinase inhibitor

Dasatinib (Kinase inhibitor)

SIH-440-25MG 25 mg
EUR 238.8
Description: The substance Dasatinib is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ).

Dasatinib (Kinase inhibitor)

SIH-440-5MG 5 mg
EUR 160.8
Description: The substance Dasatinib is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ).

Aurora kinase inhibitor-10

T63853-10mg 10mg Ask for price
Description: Aurora kinase inhibitor-10

Aurora kinase inhibitor-10

T63853-1g 1g Ask for price
Description: Aurora kinase inhibitor-10

Aurora kinase inhibitor-10

T63853-1mg 1mg Ask for price
Description: Aurora kinase inhibitor-10

Aurora kinase inhibitor-10

T63853-50mg 50mg Ask for price
Description: Aurora kinase inhibitor-10

Aurora kinase inhibitor-10

T63853-5mg 5mg Ask for price
Description: Aurora kinase inhibitor-10

IKK-? Kinase Inhibitor II

1811-1 each
EUR 189.6

IKK-? Kinase Inhibitor II

1811-5 each
EUR 574.8

Aurora kinase inhibitor-9

T62789-10mg 10mg Ask for price
Description: Aurora kinase inhibitor-9

Aurora kinase inhibitor-9

T62789-1g 1g Ask for price
Description: Aurora kinase inhibitor-9

Aurora kinase inhibitor-9

T62789-1mg 1mg Ask for price
Description: Aurora kinase inhibitor-9

Aurora kinase inhibitor-9

T62789-50mg 50mg Ask for price
Description: Aurora kinase inhibitor-9

Aurora kinase inhibitor-9

T62789-5mg 5mg Ask for price
Description: Aurora kinase inhibitor-9

Aurora kinase inhibitor-8

T63773-10mg 10mg Ask for price
Description: Aurora kinase inhibitor-8

Aurora kinase inhibitor-8

T63773-1g 1g Ask for price
Description: Aurora kinase inhibitor-8

Aurora kinase inhibitor-8

T63773-1mg 1mg Ask for price
Description: Aurora kinase inhibitor-8

Aurora kinase inhibitor-8

T63773-50mg 50mg Ask for price
Description: Aurora kinase inhibitor-8

Aurora kinase inhibitor-8

T63773-5mg 5mg Ask for price
Description: Aurora kinase inhibitor-8

Aurora kinase inhibitor-3

T5524-10mg 10mg Ask for price
Description: Aurora kinase inhibitor-3

Aurora kinase inhibitor-3

T5524-1g 1g Ask for price
Description: Aurora kinase inhibitor-3

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