Chimère antigeen receptor T-cellen (CAR-T-cellen) de toekomst in immunotherapie voor auto-immuunziekten?
Doelstelling: CAR-T-celtherapie heeft een revolutie teweeggebracht in de behandeling van oncologische ziekten en recentelijk zijn mogelijke toepassingen bij auto-immuunziekten beschreven. De beoordeling heeft tot doel de beschikbare gegevens over de behandeling met CAR-T-cellen te integreren, met de nadruk op auto-immuunziekten, om de therapeutische vooruitgang en hun mogelijke toekomstige klinische toepasbaarheid bij auto-immuniteit te bepalen.
Materialen en methoden: Er is gezocht in PubMed met de trefwoorden “Chimeric Antigen Receptor” en “CART cell”. De relevante documenten werden geselecteerd en de informatie werd kritisch bekeken.
Resultaten: Bij de behandeling van auto-immuunziekten zijn in preklinische modellen drie verschillende cellulaire strategieën gebruikt, waaronder chimere antigeenreceptor T-cellen, chimere auto-antilichaamreceptor T-cellen en chimere antigeenreceptor in regulerende T-lymfocyten . Alle drie soorten therapie zijn effectief geweest. De mogelijke nadelige effecten daarin, het cytokine-afgiftesyndroom, cellulaire toxiciteit en neurotoxiciteit moeten altijd in gedachten worden gehouden.
Conclusies: Hoewel er nog geen informatie over mensen beschikbaar is, laten preklinische modellen van CAR-T-cellen bij de behandeling van auto-immuunziekten veelbelovende resultaten zien, zodat ze in de toekomst een nuttige en effectieve therapie kunnen worden bij de behandeling van deze pathologieën.
Ovalbumine Antigen -Specifieke Activatie van menselijke T-cel -receptor lijkt sterk op Oplosbare Antibody Stimulatieter onthuld door BOOST fosfotyrosine Proteomics
Activering van de T-celreceptor (TCR) leidt tot een netwerk van vroege signalering, voornamelijk georkestreerd door tyrosinefosforylering in T-cellen. De TCR wordt gewoonlijk geactiveerd met behulp van oplosbare anti-TCR-antilichamen, maar deze benadering is niet antigeenspecifiek. Als alternatief wordt aangenomen dat het activeren van de TCR met behulp van specifieke antigenen met een reeks bindingsaffiniteiten in de vorm van een peptide-major histocompatibiliteitscomplex (pMHC) meer fysiologisch is. Vanwege het ontbreken van grootschalige fosfotyrosine (pTyr) proteomische onderzoeken die anti-TCR-antilichamen en pMHC rechtstreeks vergelijken, blijft een uitgebreide definitie van deze geactiveerde toestanden echter raadselachtig.
Opheldering van het tyrosinefosfoproteoom met behulp van kwantitatieve pTyr-proteomics maakt een beter begrip mogelijk van de unieke kenmerken van deze activerende middelen en de rol van ligandbindingsaffiniteit op signalering. Hier passen we de latest opgerichte breedspectrumoptimalisatie van selectieve triggering (BOOST) toe om verstoringen in tyrosinefosforylering van menselijke TCR te onderzoeken, veroorzaakt door anti-TCR-antilichamen en pMHC. Onze gegevens laten zien dat pMHC-activering met hoge affiniteit ovalbumine (OVA) van de menselijke TCR een grotendeels vergelijkbare, zij het mogelijk sterkere, pTyr-gemedieerdesignaalregulerende as vergeleken met het anti-TCR-antilichaam. De signaleringsoutput die resulteert uit OVA pMHC-varianten correleert goed met hun zwakkere affiniteiten, waardoor affiniteit-afstembare controle van de signaalsterkte mogelijk is. Gezamenlijk bieden we een raamwerk voor het toepassen van BOOST om pTyr-gemedieerde signaalroutes van menselijke T-cellen te vergelijken die op een antigeenonafhankelijke en antigeenspecifieke manier zijn geactiveerd.
HIV-1 p24 recombinant antigen. |
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MBS485187-01mg | MyBiosource | 0.1mg | EUR 300 |
HIV-1 p24 recombinant antigen. |
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MBS485187-1mg | MyBiosource | 1mg | EUR 1300 |
HIV-1 p24 recombinant antigen. |
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MBS485187-5x1mg | MyBiosource | 5x1mg | EUR 5795 |
HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations) |
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0801002 | Cusabio | 96T | EUR 657.79 |
Description: Please contact Gentaur in order to receive the datasheet of the product. |
HIV-1 gag p24 antigen (RECOMBINANT) |
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HI1A-720-4 | Austral Biologicals | 50ug | EUR 295 |
HIV-1 gag p24 antigen (RECOMBINANT) |
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HI1A-720-5 | Austral Biologicals | 100ug | EUR 495 |
HIV-P24 antigen array kit |
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VArk-Lsx001 | Creative Biolabs | unit | Ask for price |
Description: Fourth-generation HIV immunoassays detect viral p24 protein in the blood. |
Human HIV-1 And HIV-2 Antibodies Plus P24 Antigen Fourth-Generation ELISA Kit |
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abx257575-05mg | Abbexa | 0.5 mg | Ask for price |
Human HIV-1 And HIV-2 Antibodies Plus P24 Antigen Fourth-Generation ELISA Kit |
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abx257575-100g | Abbexa | 100 µg | EUR 468.75 |
Human HIV-1 And HIV-2 Antibodies Plus P24 Antigen Fourth-Generation ELISA Kit |
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abx257575-1mg | Abbexa | 1 mg | Ask for price |
Recombinant HIV-1 p24 Core Antigen |
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HIV-277 | Creative BioMart | 1 vial | EUR 798.4 |
Description: Protein |
HIV-1 p17-p24 recombinant antigen. |
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00172-V | Virogen | 1 MG | EUR 850 |
HIV-1 p17-p24 recombinant antigen. |
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00172-V-100ugvial | Virogen | 100ug/vial | EUR 150 |
Description: HIV-1 p17-p24 recombinant antigen. |
HIV-1 p17-p24 recombinant antigen. |
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MBS485154-01mg | MyBiosource | 0.1mg | EUR 300 |
HIV-1 p17-p24 recombinant antigen. |
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MBS485154-1mg | MyBiosource | 1mg | EUR 1300 |
HIV-1 p17-p24 recombinant antigen. |
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MBS485154-5x1mg | MyBiosource | 5x1mg | EUR 5795 |
Antibody against HIV P24 antigen |
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MBS478168-10mg | MyBiosource | 10mg | EUR 1560 |
Antibody against HIV P24 antigen |
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MBS478168-1mg | MyBiosource | 1mg | EUR 275 |
Antibody against HIV P24 antigen |
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MBS478168-20mg | MyBiosource | 20mg | EUR 2570 |
Antibody against HIV P24 antigen |
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MBS478168-50mg | MyBiosource | 50mg | EUR 6185 |
Antibody against HIV P24 antigen |
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MBS478168-5mg | MyBiosource | 5mg | EUR 840 |
Antibody against HIV P24 antigen |
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MBS478169-10mg | MyBiosource | 10mg | EUR 1560 |
Antibody against HIV P24 antigen |
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MBS478169-1mg | MyBiosource | 1mg | EUR 275 |
Antibody against HIV P24 antigen |
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MBS478169-20mg | MyBiosource | 20mg | EUR 2570 |
Antibody against HIV P24 antigen |
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MBS478169-50mg | MyBiosource | 50mg | EUR 6185 |
Antibody against HIV P24 antigen |
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MBS478169-5mg | MyBiosource | 5mg | EUR 840 |
Antibody against HIV P24 antigen |
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MBS478170-10mg | MyBiosource | 10mg | EUR 1560 |
Antibody against HIV P24 antigen |
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MBS478170-1mg | MyBiosource | 1mg | EUR 275 |
Antibody against HIV P24 antigen |
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MBS478170-20mg | MyBiosource | 20mg | EUR 2570 |
Antibody against HIV P24 antigen |
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MBS478170-50mg | MyBiosource | 50mg | EUR 6185 |
Antibody against HIV P24 antigen |
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MBS478170-5mg | MyBiosource | 5mg | EUR 840 |
Antibody against HIV P24 antigen |
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MBS478171-10mg | MyBiosource | 10mg | EUR 1560 |
Antibody against HIV P24 antigen |
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MBS478171-1mg | MyBiosource | 1mg | EUR 275 |
Antibody against HIV P24 antigen |
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MBS478171-20mg | MyBiosource | 20mg | EUR 2570 |
Antibody against HIV P24 antigen |
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MBS478171-50mg | MyBiosource | 50mg | EUR 6185 |
Antibody against HIV P24 antigen |
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MBS478171-5mg | MyBiosource | 5mg | EUR 840 |
HIV-1 GAG P24 Recombinant Antigen |
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00111-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
HIV-1 GAG P24 Recombinant Antigen |
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00111-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
HIV 1 p24 core recombinant antigen. |
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00177-V | Virogen | 1 MG | EUR 850 |
HIV 1 p24 core recombinant antigen |
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00177-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HIV 1 p24 core recombinant antigen. |
HIV 1 p24 core recombinant antigen |
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00177-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HIV 1 p24 core recombinant antigen. |
HIV 1 p24 core recombinant antigen. |
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00177-V-100ugvial | Virogen | 100ug/vial | EUR 150 |
Description: HIV 1 p24 core recombinant antigen. |
HIV 1 p24 core recombinant antigen. |
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MBS485109-01mg | MyBiosource | 0.1mg | EUR 300 |
HIV 1 p24 core recombinant antigen. |
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MBS485109-1mg | MyBiosource | 1mg | EUR 1300 |
HIV 1 p24 core recombinant antigen. |
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MBS485109-5x1mg | MyBiosource | 5x1mg | EUR 5795 |
HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations) |
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0801200 | Zeptometrix | 5 X 96T | EUR 2563 |
HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations) |
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801200 | Zeptometrix | 5 X 96 Determinations | EUR 2563 |
Recombinant HIV-1 p24 Antigen, His-tagged |
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HIV-276 | Creative BioMart | 1 vial | EUR 798.4 |
Description: Protein |
Recombinant HIV-1 p24 Antigen, His-tagged |
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HIV-281 | Creative BioMart | 1 vial | EUR 798.4 |
Description: Protein |
HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations) |
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0801008 | Zeptometrix | 5 X 96T | EUR 2505 |
Human HIV(1+2 antibodies plus p24 antigen (4th Generation) ELISA Kit |
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EH4101 | FN Test | 96T | EUR 571.5 |
Description: Method of detection: Qualitative ;Reacts with: Homo sapiens;Sensitivity: Qualitative |
Mouse Anti Human Immunodeficiency Virus (HIV-1) p24 (1947) |
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MAB12321-100 | The Native Antigen Company | 0.1 | EUR 275.56 |
Description: Mouse monoclonal antibody specific for HIV-1 p24 |
Mouse Anti Human Immunodeficiency Virus (HIV-1) p24 (1947) |
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MAB12321-500 | The Native Antigen Company | 0.5 | EUR 671.04 |
Description: Mouse monoclonal antibody specific for HIV-1 p24 |
HIV-1 gag p24 antigen IgG fraction (monoclonal) |
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HI1M-721-5 | Austral Biologicals | 100ug | EUR 425 |
Human Immunodeficiency Virus (HIV) p24 Antigen >95% |
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MBS568670-1mg | MyBiosource | 1mg | EUR 2175 |
Human Immunodeficiency Virus (HIV) p24 Antigen >95% |
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MBS568670-5x1mg | MyBiosource | 5x1mg | EUR 9585 |
Recombinant HIV-1 p24 Antigen, GST-tagged, HRP-Labled |
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HIV-282 | Creative BioMart | 1 vial | EUR 798.4 |
Description: Protein |
Rat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614549-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3290 |
Rat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614549-48StripWells | MyBiosource | 48-Strip-Wells | EUR 295 |
Rat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614549-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1800 |
Rat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614549-96StripWells | MyBiosource | 96-Strip-Wells | EUR 450 |
Goat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614545-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3545 |
Goat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614545-48StripWells | MyBiosource | 48-Strip-Wells | EUR 310 |
Goat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614545-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1940 |
Goat HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614545-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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NSL1389Hu | Sunlong | 96 wells | EUR 468 |
Mouse HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614547-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3290 |
Mouse HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614547-48StripWells | MyBiosource | 48-Strip-Wells | EUR 295 |
Mouse HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614547-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1800 |
Mouse HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614547-96StripWells | MyBiosource | 96-Strip-Wells | EUR 450 |
Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2602892-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3040 |
Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2602892-48StripWells | MyBiosource | 48-Strip-Wells | EUR 285 |
Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2602892-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1670 |
Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2602892-96StripWells | MyBiosource | 96-Strip-Wells | EUR 405 |
Human HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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EIA06774h | Enlibio | each | EUR 430 |
Bovine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2610168-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3545 |
Bovine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2610168-48StripWells | MyBiosource | 48-Strip-Wells | EUR 310 |
Bovine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2610168-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1940 |
Bovine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2610168-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Canine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614543-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3545 |
Canine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614543-48StripWells | MyBiosource | 48-Strip-Wells | EUR 310 |
Canine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614543-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1940 |
Canine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614543-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Rabbit HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614550-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3545 |
Rabbit HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614550-48StripWells | MyBiosource | 48-Strip-Wells | EUR 310 |
Rabbit HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614550-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1940 |
Rabbit HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614550-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Chicken HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614544-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3545 |
Chicken HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614544-48StripWells | MyBiosource | 48-Strip-Wells | EUR 310 |
Chicken HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614544-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1940 |
Chicken HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614544-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Porcine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614548-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3545 |
Porcine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614548-48StripWells | MyBiosource | 48-Strip-Wells | EUR 310 |
Porcine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614548-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1940 |
Porcine HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614548-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
Recombinant HIV-1 gag p17 and p24 Antigen, GST-tagged |
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PT2-332 | Creative BioMart | 1 vial | EUR 798.4 |
Description: Protein |
Recombinant HIV-1 p24 gag Antigen, beta-galactosidase-tagged |
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HIV-278 | Creative BioMart | 1 vial | EUR 798.4 |
Description: Protein |
Human Immunodeficiency Virus p24 Protein [HIV-1/Clade B] |
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REC31743-100 | The Native Antigen Company | 0.1 | EUR 496.27 |
Description: Recombinant HIV p24 protein (NCBI accession number ABO61536, AA35-265, L40I) produced in HEK293 cells. Protein carries a C-terminal His-tag.. Protein was purified by immobilised metal affinity and ion exchange chromatography from the pellet of transfected cells. |
Human Immunodeficiency Virus p24 Protein [HIV-1/Clade B] |
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REC31743-500 | The Native Antigen Company | 0.5 | EUR 1363.78 |
Description: Recombinant HIV p24 protein (NCBI accession number ABO61536, AA35-265, L40I) produced in HEK293 cells. Protein carries a C-terminal His-tag.. Protein was purified by immobilised metal affinity and ion exchange chromatography from the pellet of transfected cells. |
Human Immunodeficiency Virus P24 Protein [HIV-1/Clade C] |
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REC31706-100 | The Native Antigen Company | 0.1 | EUR 457.08 |
Description: Recombinant HIV-1 p24 produced in E. coli with a 6x histidine tag. |
Human Immunodeficiency Virus P24 Protein [HIV-1/Clade C] |
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REC31706-500 | The Native Antigen Company | 0.5 | EUR 1167.82 |
Description: Recombinant HIV-1 p24 produced in E. coli with a 6x histidine tag. |
Bovine HIV-1 p24 core protein(HIV-1 p24) Anti-body ELISA Kit |
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NSL1181Bo | Sunlong | 96 T | EUR 528 |
Guinea pig HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614546-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3545 |
Guinea pig HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614546-48StripWells | MyBiosource | 48-Strip-Wells | EUR 310 |
Guinea pig HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
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MBS2614546-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1940 |
Guinea pig HIV-1 p24 core protein (HIV-1 p24) antibody ELISA Kit |
|||
MBS2614546-96StripWells | MyBiosource | 96-Strip-Wells | EUR 475 |
HIV-1 p24 ELISA Kit |
|||
Z7040001 | Biochain | 1 kit | EUR 865 |
HIV-1 p24 ELISA Kit |
|||
MBS412756-5x960Tests | MyBiosource | 5x960Tests | EUR 17580 |
HIV-1 p24 ELISA Kit |
|||
MBS412756-960Tests | MyBiosource | 960Tests | EUR 3770 |
HIV-1 p24 ELISA Kit |
|||
MBS412756-96Tests | MyBiosource | 96Tests | EUR 510 |
Recombinant HIV-1 p24 Antigen, beta-galactosidase-tagged, Biotin-Labled |
|||
HIV-280 | Creative BioMart | 1 vial | EUR 798.4 |
Description: Protein |
Recombinant HIV-1 gag p17-p24 and gp41-gp120 Antigen |
|||
VAC-0333 | Creative BioMart | 0.5ml | EUR 1598.4 |
Description: Protein |
OPEF01414-1MG - Recombinant Human Immunodeficiency Virus 1 (HIV 1-p24) Antigen |
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OPEF01414-1MG | Aviva Systems Biology | 1mg | EUR 2216 |
Recombinant HIV-1 gag p17, p24 and gp120 Antigen, GST-tagged |
|||
THP-0332 | Creative BioMart | 1 vial | EUR 2398.4 |
Description: Protein |
Human HIV (1+2) antigen&antibody ELISA Kit |
|||
EK11777 | SAB | 96Т | EUR 799 |
Human HIV (1+2) antigen&antibody ELISA Kit |
|||
AE62582HU-48Tests | Abebio | 48 Tests | EUR 360 |
Description: Human (Homo sapiens) |
Human HIV (1+2) antigen&antibody ELISA Kit |
|||
AE62582HU-96Tests | Abebio | 96 Tests | EUR 680 |
Description: Human (Homo sapiens) |
Human HIV (1+2) antigen&antibody ELISA Kit |
|||
AE62582HU-48T | Abebio | 48T | EUR 360 |
Description: Human (Homo sapiens) |
Human HIV (1+2) antigen&antibody ELISA Kit |
|||
AE62582HU-96T | Abebio | 96T | EUR 680 |
Description: Human (Homo sapiens) |
Human HIV (1+2) antigen&antibody ELISA Kit |
|||
MBS2800305-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6840 |
Human HIV (1+2) antigen&antibody ELISA Kit |
|||
MBS2800305-48StripWells | MyBiosource | 48-Strip-Wells | EUR 480 |
Human HIV (1+2) antigen&antibody ELISA Kit |
|||
MBS2800305-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3610 |
Human HIV (1+2) antigen&antibody ELISA Kit |
|||
MBS2800305-96StripWells | MyBiosource | 96-Strip-Wells | EUR 805 |
Human HIV (1+2) Antigen & Antibody ELISA Kit |
|||
MBS3802470-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Human HIV (1+2) Antigen & Antibody ELISA Kit |
|||
MBS3802470-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Human HIV (1+2) Antigen & Antibody ELISA Kit |
|||
MBS3802470-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Human HIV (1+2) Antigen & Antibody ELISA Kit |
|||
MBS3802470-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
|||
00111-V | Virogen | 1 MG | EUR 850 |
HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
|||
00111-V-100ugvial | Virogen | 100ug/vial | EUR 150 |
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
|||
MBS485158-01mg | MyBiosource | 0.1mg | EUR 300 |
HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
|||
MBS485158-1mg | MyBiosource | 1mg | EUR 1300 |
HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
|||
MBS485158-5x1mg | MyBiosource | 5x1mg | EUR 5795 |
Extended Range HIV-1 p24 ELISA Kit |
|||
MBS412758-5x96Samples | MyBiosource | 5x96Samples | EUR 2575 |
Extended Range HIV-1 p24 ELISA Kit |
|||
MBS412758-96Samples | MyBiosource | 96Samples | EUR 560 |
HIV-1 p24 (group O, strain BCF06) Antibody, Rabbit Pab, Antigen Affinity Purified |
|||
MBS8119499-002mL | MyBiosource | 0.02mL | EUR 185 |
HIV-1 p24 (group O, strain BCF06) Antibody, Rabbit Pab, Antigen Affinity Purified |
|||
MBS8119499-01mL | MyBiosource | 0.1mL | EUR 385 |
HIV-1 p24 (group O, strain BCF06) Antibody, Rabbit Pab, Antigen Affinity Purified |
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MBS8119499-5x01mL | MyBiosource | 5x0.1mL | EUR 1590 |
HIV-1 p17/24/gp120 antigen |
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00169-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120. |
HIV-1 p17/24/gp120 antigen |
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00169-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120. |
HIV-1 nef antigen |
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GWB-633F8F | GenWay Biotech | 0.5 mg | Ask for price |
HIV-1 gag p17 antigen (RECOMBINANT) |
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HI1A-710-4 | Austral Biologicals | 50ug | EUR 295 |
HIV-1 gag p17 antigen (RECOMBINANT) |
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HI1A-710-5 | Austral Biologicals | 100ug | EUR 495 |
HIV-1 gag p55 antigen (RECOMBINANT) |
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HI1A-730-4 | Austral Biologicals | 50ug | EUR 295 |
HIV-1 gag p55 antigen (RECOMBINANT) |
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HI1A-730-5 | Austral Biologicals | 100ug | EUR 495 |
Recombinant HIV-1 p55 gag Antigen |
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HIV-283 | Creative BioMart | 1 vial | EUR 798.4 |
Description: Protein |
Recombinant HIV-1 p66 pol Antigen |
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HIV-284 | Creative BioMart | 1 vial | EUR 798.4 |
Description: Protein |
HIV-1 p24 (HIV-1) |
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GWB-420F7B | GenWay Biotech | 0.1 mg | Ask for price |
HIV-1 envelope p31 antigen (RECOMBINANT) |
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HI1A-700-4 | Austral Biologicals | 50ug | EUR 295 |
HIV-1 envelope p31 antigen (RECOMBINANT) |
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HI1A-700-5 | Austral Biologicals | 100ug | EUR 495 |
HIV-1 intergase antigen |
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00199-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HIV-1 intergase antigen. The protein contains the HIV-1 immunodominant regions from pol protein (integrase). |
HIV-1 intergase antigen |
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00199-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HIV-1 intergase antigen. The protein contains the HIV-1 immunodominant regions from pol protein (integrase). |
HIV-1 (group M, subtype B, strain 92418) p24 Antibody, Rabbit PAb, Antigen Affinity Purified |
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MBS8105664-002mL | MyBiosource | 0.02mL | EUR 185 |
HIV-1 (group M, subtype B, strain 92418) p24 Antibody, Rabbit PAb, Antigen Affinity Purified |
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MBS8105664-01mL | MyBiosource | 0.1mL | EUR 385 |
HIV-1 (group M, subtype B, strain 92418) p24 Antibody, Rabbit PAb, Antigen Affinity Purified |
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MBS8105664-5x01mL | MyBiosource | 5x0.1mL | EUR 1590 |
HIV-1 Recombinant antigen |
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MBS320616-01mg | MyBiosource | 0.1mg | EUR 440 |
HIV-1 Recombinant antigen |
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MBS320616-5x01mg | MyBiosource | 5x0.1mg | EUR 1885 |
HIV-1 Recombinant antigen |
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MBS320617-01mg | MyBiosource | 0.1mg | EUR 440 |
HIV-1 Recombinant antigen |
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MBS320617-5x01mg | MyBiosource | 5x0.1mg | EUR 1885 |
HIV-1 Recombinant antigen |
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MBS320618-01mg | MyBiosource | 0.1mg | EUR 630 |
HIV-1 Recombinant antigen |
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MBS320618-5x01mg | MyBiosource | 5x0.1mg | EUR 2745 |
HIV-1 p24 Antibody |
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20-abx137062 | Abbexa |
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HIV-1 p24 Antibody |
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abx023925-1mg | Abbexa | 1 mg | EUR 828 |
HIV-1 p24 Antibody |
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abx023926-1mg | Abbexa | 1 mg | EUR 828 |
HIV-1 p24 Antibody |
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abx021869-1mg | Abbexa | 1 mg | EUR 794.4 |
HIV-1 p24 Antibody |
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abx021870-1mg | Abbexa | 1 mg | EUR 760.8 |
HIV-1 p24 Antibody |
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abx021871-1mg | Abbexa | 1 mg | EUR 794.4 |
HIV-1 p24 Antibody |
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abx021872-1mg | Abbexa | 1 mg | EUR 794.4 |
HIV-1 p24 Antibody |
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abx021873-1mg | Abbexa | 1 mg | EUR 794.4 |
HIV-1 p24 Antibody |
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abx021882-1mg | Abbexa | 1 mg | EUR 1178.4 |
HIV-1 p24 Antibody |
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abx021883-1mg | Abbexa | 1 mg | EUR 1220.4 |
HIV-1 p24 Antibody |
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abx021886-1mg | Abbexa | 1 mg | EUR 1220.4 |
HIV-1 p24 Antibody |
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abx021887-1mg | Abbexa | 1 mg | EUR 1220.4 |
HIV-1 p24 Antibody |
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abx021888-1mg | Abbexa | 1 mg | EUR 1220.4 |
HIV-1 p24 Antibody |
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abx023027-1ml | Abbexa | 1 ml | EUR 693.6 |
HIV-1 p24 Antibody |
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7313-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains. |
HIV-1 p24 Antibody |
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7313-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains. |
HIV-1 p24, Antibody |
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GWB-3B2FFB | GenWay Biotech | 1 mg | Ask for price |
HIV-1 p24 Antibody |
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GWB-26647C | GenWay Biotech | 0.1 mg | Ask for price |
HIV-1 p24, Antibody |
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GWB-2D04FA | GenWay Biotech | 0.1 mg | Ask for price |
HIV-1 p24, Antibody |
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GWB-2DD7E0 | GenWay Biotech | 0.1 mg | Ask for price |
HIV-1 p24, Antibody |
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GWB-192382 | GenWay Biotech | 0.1 mg | Ask for price |
HIV-1 p24 Antibody |
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GWB-846CEC | GenWay Biotech | 1 ml | Ask for price |
HIV-1 p24, Antibody |
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GWB-9C0291 | GenWay Biotech | 0.1 mg | Ask for price |
HIV-1 p24 Antibody |
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GWB-9EAC4B | GenWay Biotech | 1 ml | Ask for price |
HIV-1 p24 Antibody |
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GWB-4CB110 | GenWay Biotech | 1 ml | Ask for price |
HIV-1 p24 Antibody |
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GWB-76A9C7 | GenWay Biotech | 0.1 mg | Ask for price |
HIV-1 p24 Antibody |
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GWB-F48F6D | GenWay Biotech | 0.1 mg | Ask for price |
HIV-1 p24, Antibody |
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GWB-B0158C | GenWay Biotech | 0.1 mg | Ask for price |
HIV-1 p24 Antibody |
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GWB-BBDE10 | GenWay Biotech | 1 ml | Ask for price |
HIV-1 p24 Antibody |
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GWB-F1D71D | GenWay Biotech | 0.1 mg | Ask for price |
Bilaterale anterior cerebrale slagader occlusie na CD19- en BCMA-gerichte chimere antigeen receptor van T-celtherapie voor een patiënt myeloom
Chimere antigeenreceptor T (CAR-T)-celtherapie is een veelbelovende behandeling voor recidiverend/refractair multipel myeloom (RRMM). In ons vorige rapport was CD19- en BCMA-gerichte gelijktijdige toediening van CAR-T geassocieerd met een hoog responspercentage. Hoewel cytokine launch syndrome (CRS) en neurotoxiciteit frequente complicaties zijn na behandeling met CAR-T, wordt een herseninfarct zelden gerapporteerd als een CAR-T-gerelateerde complicatie. We rapporteerden een 73-jarige vrouwelijke MM-patiënt die CD19- en BCMA-gerichte CAR-T ontving voor refractaire ziekte.
Haar ziekte reageerde op CAR-T- therapie, maar ze ontwikkelde neurologische symptomen na CRS. Craniale CT en MRI toonden meerdere herseninfarcten en bilaterale anterieure cerebrale arterie (ACA) occlusie aan. We suggereren dat een ander herseninfarct dan CAR-T-gerelateerde neurotoxiciteit de onderliggende oorzaak is van abnormale neuropsychologische symptomen, en diagnostische beeldvormingstests moeten actief worden uitgevoerd om ischemische cerebrovasculaire gebeurtenissen uit te sluiten.
Het intracellulaire domein van CD40 is een krachtige Costimulatoire Ingredient in chimère Antigen Receptoren
De co-stimulerende domeinen die zijn ingebouwd in chimere antigeenreceptoren (CAR’s) van de tweede generatie en de derde generatie, hebben een sterke invloed op de functie van CAR-T-cellen . Hier hebben we CAR’s van de tweede generatie en de derde generatie onderzocht die het signaleringsdomein van de CD40-receptor herbergen als een nieuw costimulerend component in vergelijking met vergelijkbare CAR’s die het 4-1BB-domein dragen . In CAR’s van beide generaties was CD40 krachtiger dan 4-1BB bij het triggeren van de NF-KB-signaleringsroute.
In humane T-cellen van 2 donoren was CD40 vergelijkbaar met 4-1BB bij het opreguleren van co-stimulerende en activatiemarkers, het induceren van pro-inflammatoire cytokinesecretie en het mediëren van het doden van doelwitcellen. Interessant genoeg waren er duidelijk verschillen in het responspatroon van T-cellen van de 2 donoren met betrekking tot CD40 en 4-1BB. We concluderen dat in menselijke T-cellen het CD40- signaleringsdomein een krachtig co-stimulerend component is in CAR’s van zowel de tweede generatie als de derde generatie.
Een systematische herziening van de rol van chimere Antigeen Receptor T (CAR-T) celtherapie bij de behandeling van solide tumoren
Chimere antigeenreceptor T (CAR-T) celtherapie maakt gebruik van de eigen T-lymfocyten van de patiënt die zijn ontworpen om kankercellen aan te vallen. Het is door de Meals and Drug Administration (FDA) goedgekeurd voor verschillende hematologische maligniteiten en wordt momenteel geëvalueerd bij solide kankers in vroege fase-onderzoeken. We deden een systematische evaluate bestaande uit 15 prospectieve klinische onderzoeken (n = 159) die CAR-T-cellen in solide kankers evalueerden . Vroege fase-onderzoeken toonden veelbelovende responspercentages bij ovariumepitheelkanker (100%), humaan epidermale groeifactorreceptor 2 (HER2)-positief sarcoom (67%) , epidermale groeifactorreceptor (EGFR)-positieve galwegkanker (65%), gevorderde maag-/pancreaskanker (82%), hepatocellulair carcinoom (67%),en colorectale kanker (70%) .
De mediane algehele respons voor alle maligniteiten was 62% (bereik 17%-100%) . De mediane progressievrije overleving en de totale overleving werden in de meeste onderzoeken niet bereikt. Cytokine-afgiftesyndroom werd gezien bij slechts één patiënt met cholangiocarcinoom die EGFR-specifieke CAR-T-celtherapie kreeg. Hoewel de overlevingsgegevens nog steeds niet volgroeid zijn, liet CAR-T-celtherapie bij solide maligniteiten bemoedigende responspercentages zien en werd goed verdragen.
Verschillen in lymfoompatiënten tussen chimeer antigeen receptor van T-cel therapeutische proeven en bevolking
Chimere antigeenreceptor (CAR)-T-celtherapieën lijken veelbelovende behandelingen te zijn voor non-Hodgkin- en B-cellymfoom. Verschillende CAR-T-therapieën die zijn goedgekeurd door de Amerikaanse Meals and Drug Administration, zijn echter alleen op werkzaamheid getest in relatief weinig klinische onderzoeken met een enkele arm met kleine steekproefomvang. We probeerden de verschillen tussen patiënten in deze onderzoeken en de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom te onderzoeken. Vijfhonderdtweeëntwintig patiënten uit 15 CAR-T-onderzoeken gevonden in een systematische evaluate en 417.492 patiënten uit de Surveillance, Epidemiology, and Finish Outcomes (SEER) Program-database werden vergeleken.
De deelnemers aan de CAR-T-studie leken jonger (46,7% jonger dan 70 jaar vs. 42,2%) , meer mannelijk (68,0% vs. 55,7%) en werden gedurende een kortere periode gevolgd in vergelijking met patiënten in de SEER-populatie (gemiddelde [M] 45,6 maanden, 95% betrouwbaarheidsinterval [BI] 17,7 tot 63,three maanden follow-up vs. M 57,1 maanden, 95% BI 57,Zero tot 57,three maanden overleving). Deelnemers aan de CAR-T-studie kunnen aanzienlijk verschillen van de algemene populatie van patiënten met non-Hodgkin- en B-cellymfoom . De effectiviteit van CAR-T-therapieën bij de algemene populatie van lymfoompatiënten kan verschillen van de effectiviteit die is aangetoond in onderzoeken. Nieuw gecreëerde CAR-T-patiëntenregisters zijn essentieel om de effectiviteit van de therapieën op populatieniveau huge te stellen.
ALK kinase inhibitor-1 |
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T6409-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: ALK kinase inhibitor-1 |
ALK kinase inhibitor-1 |
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T6409-1g | TargetMol Chemicals | 1g | Ask for price |
Description: ALK kinase inhibitor-1 |
ALK kinase inhibitor-1 |
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T6409-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: ALK kinase inhibitor-1 |
ALK kinase inhibitor-1 |
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T6409-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: ALK kinase inhibitor-1 |
ALK kinase inhibitor-1 |
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T6409-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: ALK kinase inhibitor-1 |
ALK kinase inhibitor-1 |
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HY-19990 | MedChemExpress | 10 mg | EUR 211.04 |
Description: ALK kinase inhibitor-1 is an anaplastic lymphoma kinase (ALK) inhibitor extracted from patent US20130261106A1 compound I-202[1]. |
TAO Kinase inhibitor 1 |
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HY-112136 | MedChemExpress | 50mg | EUR 955.2 |
TAO Kinase inhibitor 1 |
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T16987-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: TAO Kinase inhibitor 1 |
TAO Kinase inhibitor 1 |
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T16987-1g | TargetMol Chemicals | 1g | Ask for price |
Description: TAO Kinase inhibitor 1 |
TAO Kinase inhibitor 1 |
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T16987-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: TAO Kinase inhibitor 1 |
TAO Kinase inhibitor 1 |
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T16987-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: TAO Kinase inhibitor 1 |
TAO Kinase inhibitor 1 |
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T16987-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: TAO Kinase inhibitor 1 |
TAO Kinase inhibitor 1 |
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MBS5755584-10mg | MyBiosource | 10mg | EUR 195 |
TAO Kinase inhibitor 1 |
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MBS5755584-25mg | MyBiosource | 25mg | EUR 300 |
TAO Kinase inhibitor 1 |
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MBS5755584-2mg | MyBiosource | 2mg | EUR 145 |
TAO Kinase inhibitor 1 |
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MBS5755584-50mg | MyBiosource | 50mg | EUR 460 |
TAO Kinase inhibitor 1 |
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MBS5755584-5mg | MyBiosource | 5mg | EUR 160 |
Tpl2 Kinase Inhibitor 1 |
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T17145-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Tpl2 Kinase Inhibitor 1 |
Tpl2 Kinase Inhibitor 1 |
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T17145-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Tpl2 Kinase Inhibitor 1 |
Tpl2 Kinase Inhibitor 1 |
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T17145-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Tpl2 Kinase Inhibitor 1 |
Tpl2 Kinase Inhibitor 1 |
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T17145-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Tpl2 Kinase Inhibitor 1 |
Tpl2 Kinase Inhibitor 1 |
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T17145-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Tpl2 Kinase Inhibitor 1 |
RIP1 kinase inhibitor 1 |
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T12725-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: RIP1 kinase inhibitor 1 |
RIP1 kinase inhibitor 1 |
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T12725-1g | TargetMol Chemicals | 1g | Ask for price |
Description: RIP1 kinase inhibitor 1 |
RIP1 kinase inhibitor 1 |
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T12725-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: RIP1 kinase inhibitor 1 |
RIP1 kinase inhibitor 1 |
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T12725-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: RIP1 kinase inhibitor 1 |
RIP1 kinase inhibitor 1 |
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T12725-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: RIP1 kinase inhibitor 1 |
RIP2 kinase inhibitor 1 |
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T12727-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: RIP2 kinase inhibitor 1 |
RIP2 kinase inhibitor 1 |
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T12727-1g | TargetMol Chemicals | 1g | Ask for price |
Description: RIP2 kinase inhibitor 1 |
RIP2 kinase inhibitor 1 |
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T12727-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: RIP2 kinase inhibitor 1 |
RIP2 kinase inhibitor 1 |
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T12727-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: RIP2 kinase inhibitor 1 |
RIP2 kinase inhibitor 1 |
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T12727-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: RIP2 kinase inhibitor 1 |
Tie2 kinase inhibitor 1 |
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T6335-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Tie2 kinase inhibitor 1 |
Tie2 kinase inhibitor 1 |
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T6335-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Tie2 kinase inhibitor 1 |
Tie2 kinase inhibitor 1 |
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T6335-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Tie2 kinase inhibitor 1 |
Tie2 kinase inhibitor 1 |
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T6335-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Tie2 kinase inhibitor 1 |
Tie2 kinase inhibitor 1 |
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T6335-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Tie2 kinase inhibitor 1 |
EGFR kinase inhibitor 1 |
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T63648-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: EGFR kinase inhibitor 1 |
EGFR kinase inhibitor 1 |
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T63648-1g | TargetMol Chemicals | 1g | Ask for price |
Description: EGFR kinase inhibitor 1 |
EGFR kinase inhibitor 1 |
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T63648-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: EGFR kinase inhibitor 1 |
EGFR kinase inhibitor 1 |
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T63648-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: EGFR kinase inhibitor 1 |
EGFR kinase inhibitor 1 |
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T63648-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: EGFR kinase inhibitor 1 |
RIP1 kinase inhibitor 1 |
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MBS3844604-10mg | MyBiosource | 10mg | EUR 1905 |
RIP1 kinase inhibitor 1 |
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MBS3844604-1mg | MyBiosource | 1mg | EUR 430 |
RIP1 kinase inhibitor 1 |
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MBS3844604-5mg | MyBiosource | 5mg | EUR 1165 |
RIP1 kinase inhibitor 1 |
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MBS3844604-5x10mg | MyBiosource | 5x10mg | EUR 8565 |
RIP2 kinase inhibitor 1 |
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MBS3841571-10mg | MyBiosource | 10mg | EUR 615 |
RIP2 kinase inhibitor 1 |
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MBS3841571-50mg | MyBiosource | 50mg | EUR 1675 |
RIP2 kinase inhibitor 1 |
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MBS3841571-5mg | MyBiosource | 5mg | EUR 430 |
RIP2 kinase inhibitor 1 |
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MBS3841571-5x50mg | MyBiosource | 5x50mg | EUR 7520 |
Tpl2 Kinase Inhibitor 1 |
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MBS5755649-25mg | MyBiosource | 25mg | EUR 1610 |
Tpl2 Kinase Inhibitor 1 |
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MBS5755649-5x25mg | MyBiosource | 5x25mg | EUR 7095 |
RIP1 kinase inhibitor 1 |
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MBS5767491-100mg | MyBiosource | 100mg | EUR 3280 |
RIP1 kinase inhibitor 1 |
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MBS5767491-50mg | MyBiosource | 50mg | EUR 2185 |
RIP1 kinase inhibitor 1 |
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MBS5767491-5x100mg | MyBiosource | 5x100mg | EUR 14615 |
RIP2 kinase inhibitor 1 |
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MBS5767493-5mg | MyBiosource | 5mg | EUR 915 |
RIP2 kinase inhibitor 1 |
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MBS5767493-5x5mg | MyBiosource | 5x5mg | EUR 3970 |
RIP2 kinase inhibitor 1 |
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HY-133014 | MedChemExpress | Get quote | Ask for price |
Description: RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders[1]. |
Tie2 kinase inhibitor 1 |
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HY-100556 | MedChemExpress | 10 mg | EUR 1060.62 |
Description: Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2]. |
RIP1 kinase inhibitor 1 |
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HY-111409 | MedChemExpress | 10 mg | EUR 2056.31 |
Description: RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1]. |
Tpl2 Kinase Inhibitor 1 |
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HY-12358 | MedChemExpress | 1 mg | EUR 1190.49 |
Description: Tpl2 Kinase Inhibitor 1 is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2]. |
EGFR kinase inhibitor 1 |
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HY-143246 | MedChemExpress | Get quote | Ask for price |
Description: EGFR kinase inhibitor 1 is a potent EGFR inhibitor with IC50s of 37, 1.7, >300 nM for WT, l885R/T790M, L858R/T790M/C797S, respectively. EGFR kinase inhibitor 1 induces apoptosis and cell cycle arrest at G0/G1-phase. EGFR kinase inhibitor 1 inhibits the cell motility. EGFR kinase inhibitor 1 shows antiproliferative and anti-tumor activity[1]. |
Pim-1 kinase inhibitor 1 |
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T60972-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Pim-1 kinase inhibitor 1 |
Pim-1 kinase inhibitor 1 |
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T60972-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Pim-1 kinase inhibitor 1 |
Pim-1 kinase inhibitor 1 |
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T60972-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Pim-1 kinase inhibitor 1 |
Pim-1 kinase inhibitor 1 |
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T60972-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Pim-1 kinase inhibitor 1 |
Pim-1 kinase inhibitor 1 |
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T60972-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Pim-1 kinase inhibitor 1 |
Pim-1 kinase inhibitor 1 |
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HY-143295 | MedChemExpress | Get quote | Ask for price |
Description: Pim-1 kinase inhibitor 1 is a Pim-1 kinase inhibitor with an IC50 of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer[1]. |
PDGFRα kinase inhibitor 1 |
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T12396-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: PDGFRα kinase inhibitor 1 |
PDGFRα kinase inhibitor 1 |
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T12396-1g | TargetMol Chemicals | 1g | Ask for price |
Description: PDGFRα kinase inhibitor 1 |
PDGFRα kinase inhibitor 1 |
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T12396-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: PDGFRα kinase inhibitor 1 |
PDGFRα kinase inhibitor 1 |
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T12396-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: PDGFRα kinase inhibitor 1 |
PDGFRα kinase inhibitor 1 |
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T12396-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: PDGFRα kinase inhibitor 1 |
PDGFRα kinase inhibitor 1 |
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HY-111507 | MedChemExpress | 10 mg | EUR 1785.74 |
Description: PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1]. |
PDGFRalpha kinase inhibitor 1 |
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MBS3844085-10mg | MyBiosource | 10mg | EUR 685 |
PDGFRalpha kinase inhibitor 1 |
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MBS3844085-50mg | MyBiosource | 50mg | EUR 1915 |
PDGFRalpha kinase inhibitor 1 |
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MBS3844085-5mg | MyBiosource | 5mg | EUR 425 |
PDGFRalpha kinase inhibitor 1 |
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MBS3844085-5x100mg | MyBiosource | 5x100mg | EUR 16900 |
PDGFRalpha kinase inhibitor 1 |
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MBS3844085-100mg | MyBiosource | 100mg | EUR 3755 |
PDGFRalpha kinase inhibitor 1 |
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MBS5753656-100mg | MyBiosource | 100mg | EUR 2840 |
PDGFRalpha kinase inhibitor 1 |
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MBS5753656-25mg | MyBiosource | 25mg | EUR 1170 |
PDGFRalpha kinase inhibitor 1 |
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MBS5753656-50mg | MyBiosource | 50mg | EUR 1905 |
PDGFRalpha kinase inhibitor 1 |
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MBS5753656-5x100mg | MyBiosource | 5x100mg | EUR 12620 |
Protein kinase G inhibitor-1 |
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HY-48958 | MedChemExpress | 1 mg | EUR 476.2 |
Description: Protein kinase G inhibitor-1 (Compound 270) is a mycobacterial protein kinase G inhibitor, with an IC50 of 0.9 μM. Protein kinase G inhibitor-1 can be used for mycobacterial infection research[1]. |
Pim-1/2 kinase inhibitor 1 |
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T9229-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Pim-1/2 kinase inhibitor 1 |
Pim-1/2 kinase inhibitor 1 |
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T9229-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Pim-1/2 kinase inhibitor 1 |
Pim-1/2 kinase inhibitor 1 |
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T9229-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Pim-1/2 kinase inhibitor 1 |
Pim-1/2 kinase inhibitor 1 |
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T9229-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Pim-1/2 kinase inhibitor 1 |
Pim-1/2 kinase inhibitor 1 |
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T9229-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Pim-1/2 kinase inhibitor 1 |
Pim-1 kinase inhibitor 2 |
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T62001-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Pim-1 kinase inhibitor 2 |
Pim-1 kinase inhibitor 2 |
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T62001-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Pim-1 kinase inhibitor 2 |
Pim-1 kinase inhibitor 2 |
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T62001-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Pim-1 kinase inhibitor 2 |
Pim-1 kinase inhibitor 2 |
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T62001-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Pim-1 kinase inhibitor 2 |
Pim-1 kinase inhibitor 2 |
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T62001-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Pim-1 kinase inhibitor 2 |
Pim-1 kinase inhibitor 3 |
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T61074-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Pim-1 kinase inhibitor 3 |
Pim-1 kinase inhibitor 3 |
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T61074-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Pim-1 kinase inhibitor 3 |
Pim-1 kinase inhibitor 3 |
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T61074-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Pim-1 kinase inhibitor 3 |
Pim-1 kinase inhibitor 3 |
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T61074-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Pim-1 kinase inhibitor 3 |
Pim-1 kinase inhibitor 3 |
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T61074-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Pim-1 kinase inhibitor 3 |
Pim-1 kinase inhibitor 8 |
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HY-162006 | MedChemExpress | 10 mg | EUR 936.16 |
Description: Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC50 of 14.3 nM. Pim-1 kinase inhibitor 8 has potent cytotoxicity against MCF-7 and HepG2 cells with IC50s of 0.5 and 5.27 μM, respectively. Pim-1 kinase inhibitor 8 can used in study breast cancer[1]. |
Pim-1 kinase inhibitor 10 |
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HY-162059 | MedChemExpress | Get quote | Ask for price |
Description: Pim-1 kinase inhibitor 10 (compound 13a) is a both competitive and non-competitive inhibitor of PIM-1/2 kinase. Pim-1 kinase inhibitor 10 can induce cell apoptosis and exhibits anticancer activity. Pim-1 kinase inhibitor 10 also induces caspase 3/7 activation[1]. |
Pim-1 kinase inhibitor 9 |
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HY-163119 | MedChemExpress | Get quote | Ask for price |
Description: Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against Pim-1 kinase with IC50 value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity[1]. |
Pim-1 kinase inhibitor 2 |
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HY-147785 | MedChemExpress | Get quote | Ask for price |
Description: Pim-1 kinase inhibitor 2 (Compound 13) is a potent inhibitor of Pim-1 kinase. Pim-1 kinase inhibitor 2 induces apoptosis. Pim-1 kinase inhibitor 2 has the potential for the research of cancer diseases[1]. |
Pim-1 kinase inhibitor 4 |
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HY-149976 | MedChemExpress | Get quote | Ask for price |
Description: Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC50: 17.01 nM). Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC50 of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer[1]. |
Pim-1 kinase inhibitor 5 |
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HY-149995 | MedChemExpress | Get quote | Ask for price |
Description: Pim-1 kinase inhibitor 5 (Compound 4c) is a Pim-1 kinase inhibitor (IC50: 0.61 μM). Pim-1 kinase inhibitor 5 shows cytotoxicity against cancer cells, with IC50s of 6.95-20.19 μM for HepG2, MCF-7, PC3, and HCT-116 cells[1]. |
Pim-1 kinase inhibitor 6 |
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HY-149996 | MedChemExpress | Get quote | Ask for price |
Description: Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor with IC50 value of 0.46 μM, and has significant cytotoxic effect on cancer cells[1]. |
Pim-1 kinase inhibitor 3 |
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HY-150731 | MedChemExpress | Get quote | Ask for price |
Description: Pim-1 kinase inhibitor 3 (Compound H5) is a potent Pim-1 kinase inhibitor with an IC50 of 35.13 nM[1]. |
Pan-RAF kinase inhibitor 1 |
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T63386-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Pan-RAF kinase inhibitor 1 |
Pan-RAF kinase inhibitor 1 |
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T63386-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Pan-RAF kinase inhibitor 1 |
Pan-RAF kinase inhibitor 1 |
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T63386-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Pan-RAF kinase inhibitor 1 |
Pan-RAF kinase inhibitor 1 |
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T63386-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Pan-RAF kinase inhibitor 1 |
Pan-RAF kinase inhibitor 1 |
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T63386-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Pan-RAF kinase inhibitor 1 |
Pan-RAF kinase inhibitor 1 |
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HY-142452 | MedChemExpress | Get quote | Ask for price |
Description: Pan-RAF kinase inhibitor 1 is a potent inhibitor of Pan-RAF kinase. Pan-RAF kinase inhibitor 1 regulates MAPK signaling by inhibiting RAF kinase, thereby exerting an effect on the proliferation of RAS-mutant tumor cells. Pan-RAF kinase inhibitor 1 has the potential for the research of cancer diseases (extracted from patent WO2021110141A1, compound 16B)[1]. |
EML4-ALK kinase inhibitor 1 |
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T11184-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: EML4-ALK kinase inhibitor 1 |
EML4-ALK kinase inhibitor 1 |
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T11184-1g | TargetMol Chemicals | 1g | Ask for price |
Description: EML4-ALK kinase inhibitor 1 |
EML4-ALK kinase inhibitor 1 |
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T11184-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: EML4-ALK kinase inhibitor 1 |
EML4-ALK kinase inhibitor 1 |
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T11184-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: EML4-ALK kinase inhibitor 1 |
EML4-ALK kinase inhibitor 1 |
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T11184-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: EML4-ALK kinase inhibitor 1 |
Protein kinase D inhibitor 1 |
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T61163-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Protein kinase D inhibitor 1 |
Protein kinase D inhibitor 1 |
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T61163-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Protein kinase D inhibitor 1 |